Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene.

Autor: Gong X; Eli Lilly and Company, Indianapolis, Indiana., Du J; Eli Lilly and Company, Indianapolis, Indiana., Parsons SH; Eli Lilly and Company, Indianapolis, Indiana., Merzoug FF; Eli Lilly and Company, Indianapolis, Indiana., Webster Y; Eli Lilly and Company, Indianapolis, Indiana., Iversen PW; Eli Lilly and Company, Indianapolis, Indiana., Chio LC; Eli Lilly and Company, Indianapolis, Indiana., Van Horn RD; Eli Lilly and Company, Indianapolis, Indiana., Lin X; Eli Lilly and Company, Indianapolis, Indiana., Blosser W; Eli Lilly and Company, Indianapolis, Indiana., Han B; Eli Lilly and Company, Indianapolis, Indiana., Jin S; Eli Lilly and Company, Indianapolis, Indiana., Yao S; Eli Lilly and Company, Indianapolis, Indiana., Bian H; Eli Lilly and Company, Indianapolis, Indiana., Ficklin C; Eli Lilly and Company, Indianapolis, Indiana., Fan L; Eli Lilly and Company, Indianapolis, Indiana., Kapoor A; Eli Lilly and Company, Indianapolis, Indiana., Antonysamy S; Eli Lilly and Company, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, San Diego, California., Mc Nulty AM; Eli Lilly and Company, Indianapolis, Indiana., Froning K; Eli Lilly and Company, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, San Diego, California., Manglicmot D; Eli Lilly and Company, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, San Diego, California., Pustilnik A; Eli Lilly and Company, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, San Diego, California., Weichert K; Eli Lilly and Company, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, San Diego, California., Wasserman SR; Eli Lilly and Company, Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois., Dowless M; Eli Lilly and Company, Indianapolis, Indiana., Marugán C; Eli Lilly and Company, Lilly Research Laboratories, Avenida de la Industria, Alcobendas, Spain., Baquero C; Eli Lilly and Company, Lilly Research Laboratories, Avenida de la Industria, Alcobendas, Spain., Lallena MJ; Eli Lilly and Company, Lilly Research Laboratories, Avenida de la Industria, Alcobendas, Spain., Eastman SW; Eli Lilly and Company, Alexandria Center for Life Sciences, New York, New York., Hui YH; Eli Lilly and Company, Indianapolis, Indiana., Dieter MZ; Eli Lilly and Company, Indianapolis, Indiana., Doman T; Eli Lilly and Company, Indianapolis, Indiana., Chu S; Eli Lilly and Company, Indianapolis, Indiana., Qian HR; Eli Lilly and Company, Indianapolis, Indiana., Ye XS; Eli Lilly and Company, Indianapolis, Indiana., Barda DA; Eli Lilly and Company, Indianapolis, Indiana., Plowman GD; Eli Lilly and Company, Indianapolis, Indiana., Reinhard C; Eli Lilly and Company, Indianapolis, Indiana., Campbell RM; Eli Lilly and Company, Indianapolis, Indiana., Henry JR; Eli Lilly and Company, Indianapolis, Indiana., Buchanan SG; Eli Lilly and Company, Indianapolis, Indiana. buchananse@lilly.com.

Publikováno v: Cancer discovery [Cancer Discov] 2019 Feb; Vol. 9 (2), pp. 248-263. Date of Electronic Publication: 2018 Oct 29.