PROGRESSIVE CARDIAC AMYLOIDOSIS FOLLOWING LIVER TRANSPLANTATION FOR FAMILIAL AMYLOID POLYNEUROPATHY

Autor: J.G. O'Grady, Mark J. Monaghan, Philip N. Hawkins, P. Nihoyannopoulos, N D Heaton, A. J. Stangou, Roger Williams, MB Pepys, M. Rela

Publikováno v: Transplantation. 66:229-233

Background Circulating transthyretin (TTR) is derived from the liver, and orthotopic liver transplantation (OLT) is widely performed for variant TTR-associated familial amyloid polyneuropathy (FAP). The effect of OLT on FAP-related cardiac amyloid is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e80a19fd60006f06907f4cac6ea2d2
https://doi.org/10.1097/00007890-199807270-00016

Molecular mechanisms of fibrillogenesis and the protective role of amyloid P component: two possible avenues for therapy

Autor: Mb, Pepys, Ga, Tennent, Dr, Booth, Bellotti V, Laurence Lovat, Sy, Tan, Persey MR, Wl, Hutchinson, Se, Booth, Madhoo S, Ak, Soutar, Pn, Hawkins, Van Zyl-Smit R, Jm, Campistol, Pe, Fraser, Se, Radford, Cv, Robinson, Sunde M, Lc, Serpell, Cc, Blake

Publikováno v: Europe PubMed Central

Amyloid deposits regress when the supply of fibril precursor proteins is sufficiently reduced, indicating that amyloid fibrils are degradable in vivo. Serum amyloid P component (SAP), a universal constituent of amyloid deposits, efficiently protects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::01e3af960530a2a6a66565f0ac41982f
https://pubmed.ncbi.nlm.nih.gov/8915605

Clinical Features, Diagnosis and Treatment of Familial Amyloid Polyneuropathy

Autor: A. E. Harding, Roger Williams, Philip N. Hawkins, S.E. Booth, M R Persey, C J Mathias, G Holmgren, David R. Booth, MB Pepys, Nigel Heaton, Laurence Lovat

Publikováno v: Clinical Science. 90:19P-19P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b46abc729b49564e8d424293b785c26
https://doi.org/10.1042/cs090019p

Enhanced inflammatory response in patients with preinfarction unstable angina

Autor: J. Ruth Gallimore, Luigi M. Biasucci, Antonino Buffon, Attilio Maseri, Giuseppina Caligiuri, Giovanna Liuzzo, MB Pepys, A. G. Rebuzzi

Publikováno v: Journal of the American College of Cardiology. (6):1696-1703

OBJECTIVESWe assessed the extent and the time course of the acute phase response following myocardial cell necrosis and its relationship with the presence of preinfarction unstable angina (UA).BACKGROUNDElevated levels of acute phase proteins have be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25108230200f1cfcba1803bf2d581b17

Genetic evidence for serum amyloid P component as a drug target in neurodegenerative disorders.

Autor: Schmidt AF; Institute of Cardiovascular Science, Faculty of Population Health, University College London, 69-75 Chenies Mews, London WC1E 6HX, UK.; UCL British Heart Foundation Research Accelerator, 69-75 Chenies Mews, London WC1E 6HX, UK.; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam UMC, locatie AMC Postbus 22660, 1100 DD Amsterdam, Zuidoost, The Netherlands.; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands., Finan C; Institute of Cardiovascular Science, Faculty of Population Health, University College London, 69-75 Chenies Mews, London WC1E 6HX, UK.; UCL British Heart Foundation Research Accelerator, 69-75 Chenies Mews, London WC1E 6HX, UK.; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands., Chopade S; Institute of Cardiovascular Science, Faculty of Population Health, University College London, 69-75 Chenies Mews, London WC1E 6HX, UK.; UCL British Heart Foundation Research Accelerator, 69-75 Chenies Mews, London WC1E 6HX, UK., Ellmerich S; Wolfson Drug Discovery Unit, Division of Medicine, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK., Rossor MN; UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, Queen Square, London WC1N 3BG, UK., Hingorani AD; Institute of Cardiovascular Science, Faculty of Population Health, University College London, 69-75 Chenies Mews, London WC1E 6HX, UK.; UCL British Heart Foundation Research Accelerator, 69-75 Chenies Mews, London WC1E 6HX, UK., Pepys MB; Wolfson Drug Discovery Unit, Division of Medicine, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.

Publikováno v: Open biology [Open Biol] 2024 Jul; Vol. 14 (7), pp. 230419. Date of Electronic Publication: 2024 Jul 17.