p16/p14(ARF) cell cycle regulatory pathways in primary neuroblastoma: p16 expression is associated with advanced stage disease

Autor: Omura-Minamisawa M, Mb, Diccianni, Rc, Chang, Batova A, Lj, Bridgeman, Schiff J, Sl, Cohn, Wb, London, alice yu

Publikováno v: Europe PubMed Central

p16 regulates the G(1)-S cell cycle transition by inhibiting the cyclin D-cyclin-dependent kinase (CDK)4/CDK6-mediated phosphorylation of retinoblastoma protein (pRb). We examined the possible derangement of the p16-CDK/cyclin D-pRb pathway in 40 pri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::07aa07ab1c72eaae1f251ddf465f5557
https://pubmed.ncbi.nlm.nih.gov/11705866

Universal inactivation of both p16 and p15 but not downstream components is an essential event in the pathogenesis of T-cell acute lymphoblastic leukemia

Autor: Omura-Minamisawa M, Mb, Diccianni, Batova A, Rc, Chang, Lj, Bridgeman, Yu J, Pullen J, Wp, Bowman, alice yu

Publikováno v: Europe PubMed Central

p16/p15 regulate the cell cycle pathway by inhibiting the cyclin Ds-CDK4/6 mediated phosphorylation of pRb. We reported previously that in T-cell acute lymphoblastic leukemia (T-ALL), p16 and p15 were frequently (approximately 70%) inactivated at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::778fdb093decabc4741ee7f8b6bc4df9
https://pubmed.ncbi.nlm.nih.gov/10778944

Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia

Autor: Batova A, Mb, Diccianni, Jc, Yu, Nobori T, Mp, Link, Pullen J, alice yu

Publikováno v: Europe PubMed Central

Frequent deletion of chromosome 9p21 in many cancers has suggested the presence of tumor suppressor genes in this region. Two genes mapping to 9p21, p15 and p16, encode inhibitors for cyclin-dependent kinases 4 and 6. We recently found that in T-cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2cdb714a0413d07c02dec36370f0bd6c
http://europepmc.org/abstract/med/9041181

In vitro sensitivity of T-cell lymphoblastic leukemia to UCN-01 (7-hydroxystaurosporine) is dependent on p16 protein status: a Pediatric Oncology Group study

Autor: Omura-Minamisawa M, Mb, Diccianni, Batova A, Rc, Chang, Lj, Bridgeman, Yu J, de Wit E, Fh, Kung, Jd, Pullen, alice yu

Publikováno v: Europe PubMed Central

p16 regulates the cell cycle pathway by inhibiting the cyclin Ds-cyclin-dependent kinase (CDK) 4/6-mediated phosphorylation of retinoblastoma protein (pRb). Previously, we reported that most primary T-cell acute lymphoblastic leukemia (T-ALL) harbore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3b68deb2e2dab82f08ca6aaecc7c9444
http://europepmc.org/abstract/med/11118035

KIR/KIR-ligand genotypes and clinical outcomes following chemoimmunotherapy in patients with relapsed or refractory neuroblastoma: a report from the Children's Oncology Group.

Autor: Erbe AK; Department of Human Oncology, University of Wisconsin, Madison, Wisconsin, USA Aerbe@wisc.edu., Diccianni MB; Department of Pediatrics, University of California, San Diego, California, USA., Mody R; C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, Michigan, USA., Naranjo A; Children's Oncology Group Statistics and Data Center, University of Florida, Gainesville, Florida, USA., Zhang FF; Children's Oncology Group Statistics and Data Center, Monrovia, California, USA., Birstler J; Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin, USA., Kim K; Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin, USA., Feils AS; Department of Human Oncology, University of Wisconsin, Madison, Wisconsin, USA., Hung JT; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Linkou, Taiwan., London WB; Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA., Shulkin BL; Departments of Diagnostic Imaging and Comprehensive Cancer Center, St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee, USA., Mathew V; Department of Pediatrics, University of California, San Diego, California, USA., Parisi MT; Department of Pediatrics, Seattle Children's Hospital and the University, Seattle, Washington, USA., Servaes S; Department of Pediatrics, The Children's Hospital, Philadelphia, Pennsylvania, USA., Asgharzadeh S; Department Cancer and Blood Disease Institute, Childrens Hospital of Los Angeles, Los Angeles, California, USA., Maris JM; Department of Pediatrics, The Children's Hospital, Philadelphia, Pennsylvania, USA., Park J; Department of Pediatrics, Seattle Children's Hospital and the University, Seattle, Washington, USA., Yu AL; Department of Pediatrics, University of California, San Diego, California, USA.; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital Linkou Main Branch, Taoyuan, Taiwan., Sondel PM; Department of Human Oncology, University of Wisconsin, Madison, Wisconsin, USA.; Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, USA., Bagatell R; Department of Pediatrics, The Children's Hospital, Philadelphia, Pennsylvania, USA.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2023 Feb; Vol. 11 (2).