Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice

Autor: Mp, Schön, Arya A, Ea, Murphy, Cm, Adams, Ug, Strauch, william Agace, Marsal J, Jp, Donohue, Her H, Dr, Beier, Olson S, Lefrancois L, Mb, Brenner, Mj, Grusby, Cm, Parker

Publikováno v: Europe PubMed Central

The mucosal lymphocyte integrin alpha E(CD103)beta 7 is thought to be important for intraepithelial lymphocyte (IEL) localization or function. We cloned the murine integrin gene encoding alpha E, localized it to chromosome 11, and generated integrin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0e12848b9c7d42e597cb5b9b5a223181
http://europepmc.org/abstract/med/10352281

Publisher Correction: Interferon subverts an AHR-JUN axis to promote CXCL13 ⁺ T cells in lupus.

Autor: Law C; Department of Biochemistry and Molecular Genetics, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Department of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center of Human Immunobiology, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center of Synthetic Biology, Northwestern University, Evanston, IL, USA.; Center for Genetic Medicine, Northwestern University, Chicago, IL, USA., Wacleche VS; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Cao Y; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Pillai A; Department of Biochemistry and Molecular Genetics, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Department of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center of Human Immunobiology, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center of Synthetic Biology, Northwestern University, Evanston, IL, USA.; Center for Genetic Medicine, Northwestern University, Chicago, IL, USA., Sowerby J; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Hancock B; Department of Biochemistry and Molecular Genetics, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Department of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center of Human Immunobiology, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center of Synthetic Biology, Northwestern University, Evanston, IL, USA.; Center for Genetic Medicine, Northwestern University, Chicago, IL, USA., Horisberger A; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Bracero S; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Skidanova V; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Li Z; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Adejoorin I; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Dillon E; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Benque IJ; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Nunez DP; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Simmons DP; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA., Keegan J; Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA., Chen L; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Baker T; AstraZeneca, Gaithersburg, MD, USA., Brohawn PZ; AstraZeneca, Gaithersburg, MD, USA., Al-Mossawi H; AstraZeneca, Late Respiratory and Immunology, Cambridge, UK., Hao LY; Discovery Immunology, Janssen Research & Development, Spring House, PA, USA., Jones B; Discovery Immunology, Janssen Research & Development, Spring House, PA, USA., Rao N; Discovery Immunology, Janssen Research & Development, Spring House, PA, USA., Qu Y; Merck & Co., Inc., Rahway, NJ, USA., Alves SE; Merck & Co., Inc., Rahway, NJ, USA., Jonsson AH; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, USA., Shaw KS; Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA., Vleugels RA; Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA., Massarotti E; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Costenbader KH; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Brenner MB; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Lederer JA; Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA., Hultquist JF; Division of Infectious Diseases, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Choi J; Department of Biochemistry and Molecular Genetics, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. jaehyuk.choi@northwestern.edu.; Department of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. jaehyuk.choi@northwestern.edu.; Center of Human Immunobiology, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. jaehyuk.choi@northwestern.edu.; Center of Synthetic Biology, Northwestern University, Evanston, IL, USA. jaehyuk.choi@northwestern.edu.; Center for Genetic Medicine, Northwestern University, Chicago, IL, USA. jaehyuk.choi@northwestern.edu., Rao DA; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. darao@bwh.harvard.edu.

Publikováno v: Nature [Nature] 2024 Aug; Vol. 632 (8025), pp. E6.

Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium.

Autor: Dunlap G; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Wagner A; Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Meednu N; Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA., Wang R; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Zhang F; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Rheumatology and the Center for Health Artificial Intelligence, University of Colorado School of Medicine, Aurora, CO, USA., Ekabe JC; Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA., Jonsson AH; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Wei K; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Sakaue S; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nathan A; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bykerk VP; Hospital for Special Surgery, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Donlin LT; Hospital for Special Surgery, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Goodman SM; Hospital for Special Surgery, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Firestein GS; Division of Rheumatology, Allergy and Immunology, University of California, San Diego;, La Jolla, CA, USA., Boyle DL; Division of Rheumatology, Allergy and Immunology, University of California, San Diego;, La Jolla, CA, USA., Holers VM; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, USA., Moreland LW; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, USA.; Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Tabechian D; Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA., Pitzalis C; Centre for Experimental Medicine & Rheumatology, EULAR Centre of Excellence, William Harvey Research Institute, Queen Mary University of London, London, UK.; Barts Health NHS Trust, Barts Biomedical Research Centre (BRC), National Institute for Health and Care Research (NIHR), London, UK.; Department of Biomedical Sciences, Humanitas University and Humanitas Research Hospital, Milan, Italy., Filer A; Rheumatology Research Group, Institute for Inflammation and Ageing, University of Birmingham, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.; Birmingham Tissue Analytics, Institute of Translational Medicine, University of Birmingham, Birmingham, UK.; NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK., Raychaudhuri S; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Brenner MB; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Thakar J; Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., McDavid A; Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Rao DA; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. darao@bwh.harvard.edu., Anolik JH; Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA. jennifer_anolik@urmc.rochester.edu.; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. jennifer_anolik@urmc.rochester.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Jun 11; Vol. 15 (1), pp. 4991. Date of Electronic Publication: 2024 Jun 11.

Granzyme K drives a newly-intentified pathway of complement activation.

Autor: Donado CA; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; These authors contributed equally: Carlos A. Donado, A. Helena Jonsson., Jonsson AH; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Current affiliation: Division of Rheumatology and the Center for Health Artificial Intelligence, University of Colorado School of Medicine, Aurora, CO, USA.; These authors contributed equally: Carlos A. Donado, A. Helena Jonsson., Theisen E; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA., Zhang F; Division of Rheumatology and the Center for Health Artificial Intelligence, University of Colorado School of Medicine, Aurora, CO, USA., Nathan A; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA.; Center for Data Sciences, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rupani KV; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA., Jones D; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA., Raychaudhuri S; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA USA.; Center for Data Sciences, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dwyer DF; Division of Allergy and Clinical Immunology, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA., Brenner MB; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 26. Date of Electronic Publication: 2024 May 26.

Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.

Autor: Sakaue S; Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Weinand K; Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Isaac S; Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Dey KK; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Jagadeesh K; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Kanai M; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA., Watts GFM; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Zhu Z; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Brenner MB; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., McDavid A; Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, USA., Donlin LT; Hospital for Special Surgery, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Wei K; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Price AL; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Raychaudhuri S; Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. soumya@broadinstitute.org.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.

Publikováno v: Nature genetics [Nat Genet] 2024 Apr; Vol. 56 (4), pp. 615-626. Date of Electronic Publication: 2024 Apr 09.