A Human Stem Cell-Derived Neurosensory-Epithelial Circuitry on a Chip to Model Herpes Simplex Virus Reactivation

Autor: Sharon Muggeo, Cecilia Palma, Elena Criscuolo, Nicasio Mancini, Matteo Castelli, Nicola Clementi, Clementi M M, Roberto Burioni, Marco Rasponi, Mazzara Pg, Broccoli, Luca Massimino

Publikováno v: Biomedicines; Volume 10; Issue 9; Pages: 2068

Both emerging viruses and well-known viral pathogens endowed with neurotropism can either impair directly the neuronal functions or induce physio-pathological changes by diffusing from the periphery through neurosensory-epithelial connections. Howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0713568938079b27da5b0d45a47bbea
https://hdl.handle.net/11311/1223938

A Human Stem Cell-Derived Neurosensory-Epithelial Circuitry on a Chip to Model Herpes Simplex Virus Reactivation.

Autor: Mazzara PG; Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy., Criscuolo E; Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy., Rasponi M; Department of Electronics, Information and Bioengineering, Politecnico di Milano, 20133 Milan, Italy., Massimino L; Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy., Muggeo S; Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy., Palma C; Department of Electronics, Information and Bioengineering, Politecnico di Milano, 20133 Milan, Italy., Castelli M; Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy., Clementi M; Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy.; Laboratory of Microbiology and Virology, IRCCS San Raffaele Hospital, 20132 Milan, Italy., Burioni R; Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy., Mancini N; Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy.; Laboratory of Microbiology and Virology, IRCCS San Raffaele Hospital, 20132 Milan, Italy., Broccoli V; Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.; National Research Council (CNR), Institute of Neuroscience, 20129 Milan, Italy., Clementi N; Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy.; Laboratory of Microbiology and Virology, IRCCS San Raffaele Hospital, 20132 Milan, Italy.

Publikováno v: Biomedicines [Biomedicines] 2022 Aug 24; Vol. 10 (9). Date of Electronic Publication: 2022 Aug 24.

Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal root ganglia organoid-derived sensory neurons.

Autor: Mazzara PG; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy.; Department of Neuroscience, The Scripps Research Institute, 92037, La Jolla, CA, USA., Muggeo S; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy., Luoni M; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy., Massimino L; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy., Zaghi M; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy., Valverde PT; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy., Brusco S; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy., Marzi MJ; Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT), 20139, Milan, Italy., Palma C; Department of Electronics, Information & Bioengineering, Politecnico di Milano, 20133, Milan, Italy., Colasante G; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy., Iannielli A; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy.; National Research Council (CNR), Institute of Neuroscience, 20129, Milan, Italy., Paulis M; Humanitas Clinical and Research Center, 20089, Rozzano, Milano, Italy., Cordiglieri C; National Institute of Molecular Genetics 'Romeo e Enrica Invernizzi' - INGM, 20122, Milan, Italy., Giannelli SG; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy., Podini P; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy., Gellera C; Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133, Milan, Italy., Taroni F; Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133, Milan, Italy., Nicassio F; Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT), 20139, Milan, Italy., Rasponi M; Department of Electronics, Information & Bioengineering, Politecnico di Milano, 20133, Milan, Italy., Broccoli V; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy. broccoli.vania@hsr.it.; National Research Council (CNR), Institute of Neuroscience, 20129, Milan, Italy. broccoli.vania@hsr.it.

Publikováno v: Nature communications [Nat Commun] 2020 Aug 21; Vol. 11 (1), pp. 4178. Date of Electronic Publication: 2020 Aug 21.

Coenzyme A corrects pathological defects in human neurons of PANK2-associated neurodegeneration.

Autor: Orellana DI; Proteomics of Iron Metabolism Unit, Division of Neuroscience San Raffaele Scientific Institute, Milan, Italy., Santambrogio P; Proteomics of Iron Metabolism Unit, Division of Neuroscience San Raffaele Scientific Institute, Milan, Italy., Rubio A; Stem Cells and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy., Yekhlef L; Neuroimmunology Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy., Cancellieri C; Stem Cells and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy., Dusi S; Molecular Neurogenetics Unit, Foundation IRCCS-Neurological Institute 'Carlo Besta', Milan, Italy., Giannelli SG; Stem Cells and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy., Venco P; Molecular Neurogenetics Unit, Foundation IRCCS-Neurological Institute 'Carlo Besta', Milan, Italy., Mazzara PG; Stem Cells and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy., Cozzi A; Proteomics of Iron Metabolism Unit, Division of Neuroscience San Raffaele Scientific Institute, Milan, Italy., Ferrari M; Genomic Unit for the Diagnosis of Human Pathologies, Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy Vita-Salute San Raffaele University, Milan, Italy., Garavaglia B; Molecular Neurogenetics Unit, Foundation IRCCS-Neurological Institute 'Carlo Besta', Milan, Italy., Taverna S; Neuroimmunology Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy., Tiranti V; Molecular Neurogenetics Unit, Foundation IRCCS-Neurological Institute 'Carlo Besta', Milan, Italy., Broccoli V; Stem Cells and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy Institute of Neuroscience, National Research Council, Milan, Italy., Levi S; Proteomics of Iron Metabolism Unit, Division of Neuroscience San Raffaele Scientific Institute, Milan, Italy Vita-Salute San Raffaele University, Milan, Italy levi.sonia@hsr.it.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2016 Oct 04; Vol. 8 (10), pp. 1197-1211. Date of Electronic Publication: 2016 Oct 04 (Print Publication: 2016).

Revertant fibers in the mdx murine model of Duchenne muscular dystrophy: an age- and muscle-related reappraisal.

Autor: Pigozzo SR; Centre for Neuromuscular and Neurological Disorders, University of Western Australia Queen Elizabeth II Medical Centre, Nedlands Western Australia, Australia ; Department of Biology, University of Padova, Padova, Italy., Da Re L, Romualdi C, Mazzara PG, Galletta E, Fletcher S, Wilton SD, Vitiello L

Publikováno v: PloS one [PLoS One] 2013 Aug 28; Vol. 8 (8), pp. e72147. Date of Electronic Publication: 2013 Aug 28 (Print Publication: 2013).