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Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk.

Autor: Kimura S; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Park CS; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Montefiori LE; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Iacobucci I; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Pölönen P; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Gao Q; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Arnold ED; Department of Cell and Molecular Biology and Center for Advance Genome Engineering, St. Jude Children's Research Hospital, Memphis, Tennessee., Attarbaschi A; Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria.; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Brown A; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee., Buldini B; Pediatric Hematology, Oncology and Stem Cell Transplant Division, Maternal and Child Health Department, University of Padova, Padova, Italy.; Pediatric Onco-Hematology, Stem Cell Transplant and Gene Therapy Laboratory, Istituto di Ricerca Pediatrica (IRP)-Città della Speranza, Padova, Italy., Caldwell KJ; Gilead Sciences, Inc., Foster City, California., Chang Y; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Chen C; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Cheng C; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee., Cheng Z; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee., Choi J; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama., Conter V; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Crews KR; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee., de Groot-Kruseman HA; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Deguchi T; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan., Eguchi M; Department of Pediatrics, Ehime University, Matsuyama, Japan., Muhle HE; Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Elitzur S; Department of Pediatric Hematology and Oncology, Schneider Children's Medical Center and Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Escherich G; Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Freeman BB 3rd; Preclinical Pharmacokinetic Shared Resource, St. Jude Children's Research Hospital, Memphis, Tennessee., Gu Z; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.; Department of Computational and Quantitative Medicine, Beckman Research Institute of City of Hope, Duarte, California.; Department of Systems Biology, Beckman Research Institute of City of Hope, Duarte, California., Han K; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Horibe K; Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan., Imamura T; Department of Pediatrics, Kyoto Prefectural University of Medicine, Tokyo, Japan., Jeha S; Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee., Kato M; Department of Pediatrics, Tokyo University, Tokyo, Japan., Chiew KH; Department of Paediatrics, National University of Singapore, Singapore, Singapore., Khan T; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Kicinski M; EORTC headquarters, Brussels, Belgium., Köhrer S; Labdia Labordiagnostik GmbH, Vienna, Austria., Kornblau SM; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Kotecha RS; Department of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital, Perth, Australia.; Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia.; Curtin Medical School, Curtin University, Perth, Australia., Li CK; Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong, China., Liu YC; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Locatelli F; Department of Pediatric Hematology-Oncology and Cell and Gene Therapy, IRCCS Ospedale Pediatrico Bambino Gesù, Catholic University of the Sacred Heart, Rome, Italy., Luger SM; Abramson Cancer Center, Univeristy of Pennsylvania, Philadelphia, Pennsylvania., Paietta EM; Department of Oncology, Montefiore Medical Center, Bronx, New York., Manabe A; Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan., Marquart HV; Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Masetti R; Pediatric Hematology and Oncology, IRCCS Azienda Ospedaliero Universitaria di Bologna, University of Bologna, Bologna, Italy., Maybury M; Child Health Research Centre, the University of Queensland, Brisbane, Australia., Mazilier P; Pediatric Hemato-Oncology and Transplantation, HUB - HUDERF, Brussels, Belgium., Meijerink JPP; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Mitchell S; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Miyamura T; Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan., Moore AS; Child Health Research Centre, the University of Queensland, Brisbane, Australia.; Oncology Service, Children's Health Queensland Hospital and Health Service, Brisbane, Australia., Oshima K; Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan., Pawinska-Wasikowska K; Department of Pediatric Oncology and Hematology, Jagiellonian University Medical College, Krakow, Poland., Pieters R; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Prater MS; Department of Cell and Molecular Biology and Center for Advance Genome Engineering, St. Jude Children's Research Hospital, Memphis, Tennessee., Pruett-Miller SM; Department of Cell and Molecular Biology and Center for Advance Genome Engineering, St. Jude Children's Research Hospital, Memphis, Tennessee., Pui CH; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Qu C; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Reiterova M; CLIP - Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czechia., Reyes N; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee., Roberts KG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Rowe JM; Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel., Sato A; Department of Hematology and Oncology, Miyagi Children's Hospital, Sendai, Japan., Schmiegelow K; Department of Pediatrics and Adolescent Medicine, Rigshospitalet University Hospital, København, Denmark., Schrappe M; Department of Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany., Shen S; Department of Hematology/Oncology, National Health Committee Key Laboratory of Pediatric Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Skoczeń S; Department of Pediatric Oncology and Hematology, Jagiellonian University Medical College, Krakow, Poland., Spinelli O; Hematology and Bone Marrow Transplant Unit, ASST-Papa Giovanni XXIII Hospital, Bergamo, Italy., Stary J; Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic., Svaton M; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; CLIP - Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czechia.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Takagi M; Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan., Takita J; Department of Pediatrics, Graduate School of Medicine Kyoto University, Kyoto, Japan., Tang Y; Department of Hematology/Oncology, National Health Committee Key Laboratory of Pediatric Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Teachey DT; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Thomas PG; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee., Tomizawa D; Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan., Trka J; CLIP - Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czechia., Varotto E; Pediatric Hematology, Oncology and Stem Cell Transplant Division, Maternal and Child Health Department, University of Padova, Padova, Italy., Vincent TL; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Yang JJ; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee., Yeoh AEJ; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Zhou Y; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee., Zimmermann M; Department of Pediatric Hematology and Oncology, Medical School Hannover, Hannover, Germany., Inaba H; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.; Center of Excellence for Leukemia Studies, St. Jude Children's Research Hospital, Memphis, Tennessee.

Publikováno v: Cancer discovery [Cancer Discov] 2024 Oct 04; Vol. 14 (10), pp. 1838-1859.