Intracellular C3 protects β-cells from IL-1β-driven cytotoxicity via interaction with Fyn-related kinase.

Autor: Kulak K; Section of Medical Protein Chemistry, Department of Translational Medicine, Lund University, Malmö 214-28, Sweden., Kuska K; Section of Medical Protein Chemistry, Department of Translational Medicine, Lund University, Malmö 214-28, Sweden., Colineau L; Section of Medical Protein Chemistry, Department of Translational Medicine, Lund University, Malmö 214-28, Sweden., Mckay M; Section of Medical Protein Chemistry, Department of Translational Medicine, Lund University, Malmö 214-28, Sweden., Maziarz K; Section of Medical Protein Chemistry, Department of Translational Medicine, Lund University, Malmö 214-28, Sweden., Slaby J; Section of Medical Protein Chemistry, Department of Translational Medicine, Lund University, Malmö 214-28, Sweden., Blom AM; Section of Medical Protein Chemistry, Department of Translational Medicine, Lund University, Malmö 214-28, Sweden., King BC; Section of Medical Protein Chemistry, Department of Translational Medicine, Lund University, Malmö 214-28, Sweden.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Feb 20; Vol. 121 (8), pp. e2312621121. Date of Electronic Publication: 2024 Feb 12.

Investigating the potential effects of α-synuclein aggregation on susceptibility to chronic stress in a mouse Parkinson's disease model.

Autor: Alwani A; Department of Brain Biochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland., Maziarz K; Department of Brain Biochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland., Burda G; Department of Brain Biochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland., Jankowska-Kiełtyka M; Department of Brain Biochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland., Roman A; Department of Brain Biochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland., Łyszczarz G; Department of Brain Biochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland., Er S; Faculty of Pharmacy, Drug Research Program, University of Helsinki, Helsinki, Finland.; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland., Barut J; Department of Brain Biochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland., Barczyk-Woźnicka O; Department of Cell Biology and Imaging, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387, Kraków, Poland., Pyza E; Department of Cell Biology and Imaging, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387, Kraków, Poland., Kreiner G; Department of Brain Biochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland., Nalepa I; Department of Brain Biochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland., Chmielarz P; Department of Brain Biochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland. chmiel@if-pan.krakow.pl.

Publikováno v: Pharmacological reports : PR [Pharmacol Rep] 2023 Dec; Vol. 75 (6), pp. 1474-1487. Date of Electronic Publication: 2023 Sep 19.

PREFER: A New Predictive Modeling Framework for Molecular Discovery.

Autor: Lanini J; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4002 Basel, Switzerland., Santarossa G; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4002 Basel, Switzerland., Sirockin F; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4002 Basel, Switzerland., Lewis R; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4002 Basel, Switzerland., Fechner N; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4002 Basel, Switzerland., Misztela H; AI Innovation Lab, Novartis Pharma AG, Dublin 4, Irland., Lewis S; Microsoft Research AI4Science, Cambridge CB1 2FB, U.K., Maziarz K; Microsoft Research AI4Science, Cambridge CB1 2FB, U.K., Stanley M; Microsoft Research AI4Science, Cambridge CB1 2FB, U.K., Segler M; Microsoft Research AI4Science, Cambridge CB1 2FB, U.K., Stiefl N; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4002 Basel, Switzerland., Schneider N; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4002 Basel, Switzerland.

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2023 Aug 14; Vol. 63 (15), pp. 4497-4504. Date of Electronic Publication: 2023 Jul 24.

Serum Complement Activation by C4BP-IgM Fusion Protein Can Restore Susceptibility to Antibiotics in Neisseria gonorrhoeae .

Autor: Bettoni S; Department of Translational Medicine, Lund University, Malmö, Sweden., Maziarz K; Department of Translational Medicine, Lund University, Malmö, Sweden., Stone MRL; Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Blaskovich MAT; Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Potempa J; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.; Department of Oral Immunity and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, United States., Bazzo ML; Molecular Biology, Microbiology and Serology Laboratory, Federal University of Santa Catarina, Florianópolis, Brazil., Unemo M; World Health Organization (WHO) Collaborating Centre for Gonorrhoea and other STIs, Department of Laboratory Medicine, Örebro University, Örebro, Sweden., Ram S; Department of Medicine, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, MA, United States., Blom AM; Department of Translational Medicine, Lund University, Malmö, Sweden.

Publikováno v: Frontiers in immunology [Front Immunol] 2021 Sep 01; Vol. 12, pp. 726801. Date of Electronic Publication: 2021 Sep 01 (Print Publication: 2021).

Graph neural processes for molecules: an evaluation on docking scores and strategies to improve generalization.

Autor: García-Ortegón, Miguel^1,2,3 (AUTHOR) mg770@cam.ac.uk, Seal, Srijit⁴ (AUTHOR), Rasmussen, Carl² (AUTHOR), Bender, Andreas³ (AUTHOR), Bacallado, Sergio¹ (AUTHOR)

Publikováno v: Journal of Cheminformatics. 10/23/2024, Vol. 16 Issue 1, p1-18. 18p.