Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Mazhar Adli"'
Autor:
Emily M. Pujadas Liwag, Xiaolong Wei, Nicolas Acosta, Lucas M. Carter, Jiekun Yang, Luay M. Almassalha, Surbhi Jain, Ali Daneshkhah, Suhas S. P. Rao, Fidan Seker-Polat, Kyle L. MacQuarrie, Joe Ibarra, Vasundhara Agrawal, Erez Lieberman Aiden, Masato T. Kanemaki, Vadim Backman, Mazhar Adli
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-42 (2024)
Abstract Background B-type lamins are critical nuclear envelope proteins that interact with the three-dimensional genomic architecture. However, identifying the direct roles of B-lamins on dynamic genome organization has been challenging as their joi
Externí odkaz:
https://doaj.org/article/4305f5fcf633415aacff6d99aeabee41
Autor:
Kadir Buyukcelebi, Alexander J. Duval, Fatih Abdula, Hoda Elkafas, Fidan Seker-Polat, Mazhar Adli
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Uterine fibroids (UF), that can disrupt normal uterine function and cause significant physical and psychological health problems, are observed in nearly 70% of women of reproductive age. Although heritable genetics is a significant risk fact
Externí odkaz:
https://doaj.org/article/cb4cff71b346416789a546546ce12594
Autor:
Kadir Buyukcelebi, Xintong Chen, Fatih Abdula, Hoda Elkafas, Alexander James Duval, Harun Ozturk, Fidan Seker-Polat, Qiushi Jin, Ping Yin, Yue Feng, Serdar E. Bulun, Jian Jun Wei, Feng Yue, Mazhar Adli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Nearly 70% of Uterine fibroid (UF) tumors are driven by recurrent MED12 hotspot mutations. Unfortunately, no cellular models could be generated because the mutant cells have lower fitness in 2D culture conditions. To address this, we employ
Externí odkaz:
https://doaj.org/article/f796869116f04aa3836b1d309cad5481
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Understanding the regulatory programs enabling cancer stem cells (CSCs) to self-renew and drive tumorigenicity could identify new treatments. Through comparative chromatin-state and gene expression analyses in ovarian CSCs versus non-CSCs, we identif
Externí odkaz:
https://doaj.org/article/4dfd3e46849846128b052ba6bb366912
Autor:
Jiekun Yang, Xiaolong Wei, Turan Tufan, Cem Kuscu, Hayrunnisa Unlu, Saadia Farooq, Elif Demirtas, Bryce M. Paschal, Mazhar Adli
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-15 (2018)
Abstract Background The mutational processes underlying non-coding cancer mutations and their biological significance in tumor evolution are poorly understood. To get better insights into the biological mechanisms of mutational processes in breast ca
Externí odkaz:
https://doaj.org/article/5400a3be0d2d456a8c2bb7c7e8aad587
Autor:
Karol Szlachta, Cem Kuscu, Turan Tufan, Sara J. Adair, Stephen Shang, Alex D. Michaels, Matthew G. Mullen, Natasha Lopes Fischer, Jiekun Yang, Limin Liu, Prasad Trivedi, Edward B. Stelow, P. Todd Stukenberg, J. Thomas Parsons, Todd W. Bauer, Mazhar Adli
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Predicting the response to chemotherapy is a major goal of cancer research. Here the authors use CRISPR knockout screens in pancreatic ductal adenocarcinoma cells to identify deletions synergistic with MEK inhibitors.
Externí odkaz:
https://doaj.org/article/5878576fa2b34029942f52a332a9c423
Autor:
Mazhar Adli
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
CRISPR has rapidly become an indispensable tool for biological research. Here Mazhar Adli reviews the current toolbox for editing and manipulating the genome and looks toward future developments in this fast moving field.
Externí odkaz:
https://doaj.org/article/c99ff468bc87400a8ce35f51305f28ad
Autor:
Peiwu Qin, Mahmut Parlak, Cem Kuscu, Jigar Bandaria, Mustafa Mir, Karol Szlachta, Ritambhara Singh, Xavier Darzacq, Ahmet Yildiz, Mazhar Adli
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
CRISPR-Cas9 has been used to image repetitive loci in live cells to explore genome organization. Here the authors demonstrate the imaging of low-repeat regions with a single-guide RNA and the imaging of a non-repetitive region, allowing the tracking
Externí odkaz:
https://doaj.org/article/9c9f9c3c40e54de893c731a5ffb04a1a
Autor:
Anuradha Illendula, Jane Gilmour, Jolanta Grembecka, Venkata Sesha Srimath Tirumala, Adam Boulton, Aravinda Kuntimaddi, Charles Schmidt, Lixin Wang, John A. Pulikkan, Hongliang Zong, Mahmut Parlak, Cem Kuscu, Anna Pickin, Yunpeng Zhou, Yan Gao, Lauren Mishra, Mazhar Adli, Lucio H. Castilla, Roger A. Rajewski, Kevin A. Janes, Monica L. Guzman, Constanze Bonifer, John H. Bushweller
Publikováno v:
EBioMedicine, Vol 8, Iss C, Pp 117-131 (2016)
Transcription factors have traditionally been viewed with skepticism as viable drug targets, but they offer the potential for completely novel mechanisms of action that could more effectively address the stem cell like properties, such as self-renewa
Externí odkaz:
https://doaj.org/article/850cfca578ff44cc88f4d9d260010cb6
Autor:
Aravinda Kuntimaddi, Nicholas J. Achille, Jeremy Thorpe, Alyson A. Lokken, Ritambhara Singh, Charles S. Hemenway, Mazhar Adli, Nancy J. Zeleznik-Le, John H. Bushweller
Publikováno v:
Cell Reports, Vol 11, Iss 5, Pp 808-820 (2015)
The MLL gene is a common target of chromosomal translocations found in human leukemia. MLL-fusion leukemia has a consistently poor outcome. One of the most common translocation partners is AF9 (MLLT3). MLL-AF9 recruits DOT1L, a histone 3 lysine 79 me
Externí odkaz:
https://doaj.org/article/47fe450047cb4afaa5f2ce1383e60300