Synthesis of methotrexate-betulonic acid hybrids and evaluation of their effect on artificial and Caco-2 cell membranes.

Autor: Semenenko OM; Department of Organic and Bioorganic Chemistry, State Scientific Institution 'Institute for Single Crystals' NAS of Ukraine, Nauky Ave., 60, 61072 Kharkiv, Ukraine., Lipson VV; Department of Organic and Bioorganic Chemistry, State Scientific Institution 'Institute for Single Crystals' NAS of Ukraine, Nauky Ave., 60, 61072 Kharkiv, Ukraine; Medicinal Chemistry Department, State Institution 'V.Ya. Danilevsky Institute for Endocrine Pathology Problems' NAMS of Ukraine, Alchevskih St., 10, 61002 Kharkiv, Ukraine; Organic Chemistry Department, V.N. Karazin Kharkiv National University, Svobody Sq., 4, 61022 Kharkiv, Ukraine. Electronic address: lipson@ukr.net., Sadchenko AO; Institute for Scintillation Materials, State Scientific Institution 'Institute for Single Crystals' NAS of Ukraine, Nauky Ave., 60, 61072 Kharkiv, Ukraine., Vashchenko OV; Institute for Scintillation Materials, State Scientific Institution 'Institute for Single Crystals' NAS of Ukraine, Nauky Ave., 60, 61072 Kharkiv, Ukraine., Kasian NA; Institute for Scintillation Materials, State Scientific Institution 'Institute for Single Crystals' NAS of Ukraine, Nauky Ave., 60, 61072 Kharkiv, Ukraine., Sviechnikova LV; Institute for Scintillation Materials, State Scientific Institution 'Institute for Single Crystals' NAS of Ukraine, Nauky Ave., 60, 61072 Kharkiv, Ukraine., Lisetski LM; Institute for Scintillation Materials, State Scientific Institution 'Institute for Single Crystals' NAS of Ukraine, Nauky Ave., 60, 61072 Kharkiv, Ukraine., Babak ML; Department of Organic and Bioorganic Chemistry, State Scientific Institution 'Institute for Single Crystals' NAS of Ukraine, Nauky Ave., 60, 61072 Kharkiv, Ukraine., Vakula VM; Department of Organic and Bioorganic Chemistry, State Scientific Institution 'Institute for Single Crystals' NAS of Ukraine, Nauky Ave., 60, 61072 Kharkiv, Ukraine; Medicinal Chemistry Department, State Institution 'V.Ya. Danilevsky Institute for Endocrine Pathology Problems' NAMS of Ukraine, Alchevskih St., 10, 61002 Kharkiv, Ukraine., Borysov OV; Enamine Ltd., 23 Chervonotkatska str., 01003 Kyiv, Ukraine., Holota YV; Enamine Ltd., 23 Chervonotkatska str., 01003 Kyiv, Ukraine., Zozulya SO; Enamine Ltd., 23 Chervonotkatska str., 01003 Kyiv, Ukraine., Borysko PO; Enamine Ltd., 23 Chervonotkatska str., 01003 Kyiv, Ukraine., Mazepa OV; A. V. Bogatsky Physico-Chemical Institute NAS of Ukraine, Lustdorfska Road, 86, 65080 Odesa, Ukraine.

Publikováno v: Steroids [Steroids] 2024 Jan; Vol. 201, pp. 109332. Date of Electronic Publication: 2023 Nov 07.