Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Mazen Y Arar"'
Autor:
Hanna E. Abboud, Myung Ja Lee, Brent Wagner, Veronique L. Barnes, Jeffrey L. Barnes, Chakradhar Velagapudi, Mandakini Patel, Robert Doss, Meenalakshmi M. Mariappan, Hannah S. Burns, Mazen Y Arar
Publikováno v:
The American Journal of Pathology. 188:768-784
In vitro models for the investigation of renal vascular development are limited. We previously showed that isolated metanephric mesenchymal (MM) and ureteric bud (UB) cells grown in three-dimensional (3D) matrices formed organoids that consisted of p
Autor:
Fengchun Ye, Fuchun Zhou, Li-Wu Qian, Jia Meng, Roble Bedolla, Shou-Jiang Gao, Tiffany Jones, Mazen Y Arar, Rosalie Moody, Hongyi Pan, Yufei Huang, Brent Wagner
Publikováno v:
Journal of Clinical Investigation. 122:1076-1081
Infections by viruses are associated with approximately 12% of human cancer. Kaposi's sarcoma-associated herpesvirus (KSHV) is causally linked to several malignancies commonly found in AIDS patients. The mechanism of KSHV-induced oncogenesis remains
Autor:
Mazen Y Arar, Nancy A. Turner, Jun Teruya, Joel L. Moake, Shiu Ki Hui, Linda G. Shaffer, Ewa Elenberg, Mini Michael, Richard J.H. Smith
Publikováno v:
Clinical Kidney Journal
A 3-month-old male infant developed an extremely severe episode of atypical hemolytic uremic syndrome (aHUS) associated with partial deficiencies of full-length complement factor H (FH; ∼15% of infant normal) and a disintegrin and metalloproteinase
Autor:
Robert J. Wyatt, Nancy D. Bridges, D. Ikle, D. Liereman, Martin Ho, Mazen Y Arar, Ruth A. McDonald, William E. Harmon, Jodi M. Smith, R. Lindblad, Paul C. Grimm
Publikováno v:
American Journal of Transplantation, 8(5), 984-989. Wiley
Pediatric renal transplant recipients were enrolled in a multicenter, randomized, double-blind trial of steroid withdrawal. Subjects received basiliximab, calcineurin inhibitor, sirolimus and steroids. Of 274 subjects enrolled, 19 (6.9%) subjects dev
Autor:
Karen Block, Yves Gorin, Goutam Ghosh Choudhury, Daniel J. Riley, Brent Wagner, Jill M. Ricono, Mazen Y Arar, Hanna E. Abboud
Publikováno v:
Journal of the American Society of Nephrology. 18:2903-2911
Mice deficient in either platelet-derived growth factor (PDGF) B chain or PDGF receptor (PDGFR) beta lack mesangial cells. PDGF stimulates proliferation and migration of metanephric mesenchymal cells, from which mesangial cells are derived. Binding o
Publikováno v:
Pediatric Nephrology. 21:1144-1152
Darbepoetin alfa, an erythropoiesis-stimulating glycoprotein, has proved efficacious in the treatment of anemia of chronic kidney disease (CKD) in adult subjects. However, little information is available from pediatric populations. We conducted an op
Autor:
Jeffrey L. Barnes, Jill M. Ricono, Mazen Y Arar, Goutam Ghosh Choudhury, Samy L. Habib, Nam Ho Kim, Hanna E. Abboud, Peng Ye
Publikováno v:
Kidney International. 66(4):1356-1364
Fibronectin induces ureteric bud cells branching and cellular cord and tubule formation. Background The extracellular matrix (ECM) protein fibronectin is involved in several stages of embryogenesis. Fibronectin exerts its effect through interaction w
Autor:
Nedal H. Arar, Mazen Y Arar, Rosemarie Plaetke, Hanna E. Abboud, Valeria Sartorio, Helen P. Hazuda
Publikováno v:
Diabetes Spectrum. 16:136-142
Objective. Diabetic nephropathy (DN) clusters in families with type 2 diabetes, suggesting a genetic susceptibility for its development and progression. We investigated DN probands’ and relatives’: 1) perceptions of the causes and clustering of D
Publikováno v:
Journal of Histochemistry & Cytochemistry. 51:141-150
Glomerular endothelial and mesangial cells may originate from the metanephric mesenchyme. We used the MAb Thy1.1, a mesangial cell marker in the adult rat kidney, and rat endothelial cell markers MAb RECA-1, MAb PECAM-1 (CD31), and MAb Flk-1 as poten
Publikováno v:
American Journal of Physiology-Renal Physiology. 282:F211-F219
Platelet-derived growth factor (PDGF) B-chain or PDGF β-receptor-deficient mice lack mesangial cells. To explore potential mechanisms for failure of PDGF A-chain to rescue mesangial cell phenotype, we investigated the biological effects and signalin