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Autor:
Brian A. Shapiro, Charles E. Chalfant, Ngoc T. Vu, Adly Yacoub, Mazen M. Gouda, Jacqueline C. Shultz, Michael D. Shultz, Jennifer A. Mietla, Margaret A. Park, Paul Dent, Paul B. Fisher
Publikováno v:
Journal of Biological Chemistry. 291:21669-21681
Melanoma differentiation-associated gene 7 (MDA-7/IL-24) exhibits cytotoxic effects on tumor cells while sparing untransformed cells, and Bcl-x(L) is reported to efficiently block the induction of cell death by MDA-7/IL-24. The expression of Bcl-x(L)