Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies

Autor: Cesnik, A.B., Darovic, S., Mihevc, S.P., Stalekar, M., Malnar, M., Motaln, H., Lee, Y.B., Mazej, J., Pohleven, J., Grosch, M., Modic, M., Fonovic, M., Turk, B., Drukker, M., Shaw, C.E., Rogelj, B.

The GGGGCC (G(4)C(2)) repeat expansion mutation in the C9ORF72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Transcription of the repeat and formation of nuclear RNA foci, which seques

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https://hdl.handle.net/1887/3201081

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Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies.

Autor: Bajc Česnik A; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia.; Graduate School of Biomedicine, Faculty of Medicine, University of Ljubljana, Ljubljana 1000, Slovenia., Darovic S; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia.; Biomedical Research Institute BRIS, Ljubljana 1000, Slovenia., Prpar Mihevc S; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia., Štalekar M; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia.; Biomedical Research Institute BRIS, Ljubljana 1000, Slovenia., Malnar M; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia.; Graduate School of Biomedicine, Faculty of Medicine, University of Ljubljana, Ljubljana 1000, Slovenia., Motaln H; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia., Lee YB; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, King's College London, London SE5 9RT, UK., Mazej J; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia.; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana 1000, Slovenia., Pohleven J; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia., Grosch M; Helmholtz Center Munich, Institute of Stem Cell Research, German Research Center for Environmental Health, Neuherberg 85764, Germany., Modic M; Helmholtz Center Munich, Institute of Stem Cell Research, German Research Center for Environmental Health, Neuherberg 85764, Germany., Fonovič M; Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana 1000, Slovenia., Turk B; Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana 1000, Slovenia., Drukker M; Helmholtz Center Munich, Institute of Stem Cell Research, German Research Center for Environmental Health, Neuherberg 85764, Germany., Shaw CE; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, King's College London, London SE5 9RT, UK., Rogelj B; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia boris.rogelj@ijs.si.; Biomedical Research Institute BRIS, Ljubljana 1000, Slovenia.; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana 1000, Slovenia.

Publikováno v: Journal of cell science [J Cell Sci] 2019 Mar 07; Vol. 132 (5). Date of Electronic Publication: 2019 Mar 07.