Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Mazdak Radjainia"'
Autor:
Ieva Drulyte, Aspen Rene Gutgsell, Pilar Lloris-Garcerá, Michael Liss, Stefan Geschwindner, Mazdak Radjainia, Jens Frauenfeld, Robin Löving
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Membrane proteins are the largest group of therapeutic targets in a variety of disease areas and yet, they remain particularly difficult to investigate. We have developed a novel one-step approach for the incorporation of membrane proteins d
Externí odkaz:
https://doaj.org/article/f178d0ff85c94367be68f1fb3cadfd98
Autor:
Gamma Chi, Qiansheng Liang, Akshay Sridhar, John B. Cowgill, Kasim Sader, Mazdak Radjainia, Pu Qian, Pablo Castro-Hartmann, Shayla Venkaya, Nanki Kaur Singh, Gavin McKinley, Alejandra Fernandez-Cid, Shubhashish M. M. Mukhopadhyay, Nicola A. Burgess-Brown, Lucie Delemotte, Manuel Covarrubias, Katharina L. Dürr
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, Chi et al. report cryo-EM structures of the human Kv3.1a channel, revealing a unique arrangement of the cytoplasmic T1 domain, which allows the interactions with the C-terminal axonal targeting motif and key components of the gating machinery.
Externí odkaz:
https://doaj.org/article/3b1f137234894981ba29f62e3c7d792a
Autor:
Siew Siew Pang, Charles Bayly-Jones, Mazdak Radjainia, Bradley A. Spicer, Ruby H. P. Law, Adrian W. Hodel, Edward S. Parsons, Susan M. Ekkel, Paul J. Conroy, Georg Ramm, Hariprasad Venugopal, Phillip I. Bird, Bart W. Hoogenboom, Ilia Voskoboinik, Yann Gambin, Emma Sierecki, Michelle A. Dunstone, James C. Whisstock
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Macrophage-expressed gene 1 (MPEG1) functions within the phagolysosome to damage engulfed microbes, presumably via forming pores in target membranes. In order to provide insights into the mechanism of MPEG1 function and membrane binding, the authors
Externí odkaz:
https://doaj.org/article/2cd82268e003405ba51038290da8f4fe
Autor:
Bradley A. Spicer, Ruby H. P. Law, Tom T. Caradoc-Davies, Sue M. Ekkel, Charles Bayly-Jones, Siew-Siew Pang, Paul J. Conroy, Georg Ramm, Mazdak Radjainia, Hariprasad Venugopal, James C. Whisstock, Michelle A. Dunstone
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
The Complement component 9 (C9) is the pore-forming component of the Membrane Attack Complex which targets pathogens. Here authors use structural biology to compare monomeric C9 to C9 within the polymeric assembly and identify the element which inhib
Externí odkaz:
https://doaj.org/article/786ad92e96b04d58a33f04be085b9901
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
Single particle cryo-EM is commonly used for the structure determination of large complexes. Here, the authors present the 3.2 Å resolution cryo-EM structure of human haemoglobin, which has a molecular weight of 64 kDa.
Externí odkaz:
https://doaj.org/article/901eebcd1f124312b1e5309b7dcbdef7
Autor:
Subir Sarker, María C. Terrón, Yogesh Khandokar, David Aragão, Joshua M. Hardy, Mazdak Radjainia, Manuel Jiménez-Zaragoza, Pedro J. de Pablo, Fasséli Coulibaly, Daniel Luque, Shane R. Raidal, Jade K. Forwood
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Circoviruses are the simplest viruses known to autonomously replicate in vertebrates. Here the authors present three structures for distinct macromolecular assemblies of the capsid protein from the beak and feather disease virus that provides insight
Externí odkaz:
https://doaj.org/article/c8385c327d1e4ceb927eef4dc53f6dca
Autor:
Maryam Khoshouei, Mazdak Radjainia, Amy J. Phillips, Juliet A. Gerrard, Alok K. Mitra, Jürgen M. Plitzko, Wolfgang Baumeister, Radostin Danev
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-5 (2016)
Although the resolution achievable with cryo-EM can now rival crystallography, its application to small protein assemblies remains challenging. Here the authors demonstrate the use of the Volta phase plate for single particle analysis and its potenti
Externí odkaz:
https://doaj.org/article/3d06cce2b2344e8f80bcc7ebd49bfda0
Autor:
Matthew J. Belousoff, Zohar Eyal, Mazdak Radjainia, Tofayel Ahmed, Rebecca S. Bamert, Donna Matzov, Anat Bashan, Ella Zimmerman, Satabdi Mishra, David Cameron, Hans Elmlund, Anton Y. Peleg, Shashi Bhushan, Trevor Lithgow, Ada Yonath
Publikováno v:
mBio, Vol 8, Iss 3 (2017)
ABSTRACT An unorthodox, surprising mechanism of resistance to the antibiotic linezolid was revealed by cryo-electron microscopy (cryo-EM) in the 70S ribosomes from a clinical isolate of Staphylococcus aureus. This high-resolution structural informati
Externí odkaz:
https://doaj.org/article/1ec9f31a43344b03be4992f9b65c601b
Autor:
Emma L Summers, Kathrin Meindl, Isabel Usón, Alok K Mitra, Mazdak Radjainia, Roberto Colangeli, David Alland, Vickery L Arcus
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38542 (2012)
Lsr2 is a small DNA-binding protein present in mycobacteria and related actinobacteria that regulates gene expression and influences the organization of bacterial chromatin. Lsr2 is a dimer that binds to AT-rich regions of chromosomal DNA and physica
Externí odkaz:
https://doaj.org/article/b8bce0e5ae9a46aeb8db490a5a85e151
Autor:
Ieva Drulyte, Aspen Rene Gutgsell, Pilar Lloris-Garcerá, Michael Liss, Stefan Geschwindner, Mazdak Radjainia, Jens Frauenfeld, Robin Löving
Membrane proteins are the largest group of therapeutic targets in a variety of disease areas and yet, they remain particularly difficult to investigate. We have developed a novel one-step approach for the incorporation of membrane proteins directly f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e4e5069317b7b8e7b53f54204703224
https://doi.org/10.1101/2022.07.05.498330
https://doi.org/10.1101/2022.07.05.498330