Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Mazdak M. Bradberry"'
Autor:
Mazdak M. Bradberry, Trenton M. Peters-Clarke, Evgenia Shishkova, Edwin R. Chapman, Joshua J. Coon
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112368- (2023)
Summary: At mammalian neuronal synapses, synaptic vesicle (SV) glycoproteins are essential for robust neurotransmission. Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs. Despite
Externí odkaz:
https://doaj.org/article/ad93c95b92b448e9b14d5c1e4caebb92
Autor:
David A. Ruhl, Ewa Bomba-Warczak, Emma T. Watson, Mazdak M. Bradberry, Tabitha A. Peterson, Trina Basu, Alyssa Frelka, Chantell S. Evans, Joseph S. Briguglio, Tamara Basta, Michael H. B. Stowell, Jeffrey N. Savas, Avtar Roopra, Robert A. Pearce, Robert C. Piper, Edwin R. Chapman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The functional role of synaptotagmin-17 (syt-17) has remained unanswered. In this study, authors demonstrate that syt-17 exists in two distinct pools in hippocampal neurons (Golgi complex and early endosomes), where it served two completely independe
Externí odkaz:
https://doaj.org/article/2285b841eadf401cae3e662ea7ba2f42
Autor:
Mazdak M. Bradberry, Edwin R. Chapman
Publikováno v:
J Physiol
SV2A, an essential transporter-like synaptic vesicle protein, is a major target for antiepileptic drugs and a receptor for clostridial neurotoxins including Botox. While SV2A is required for normal levels of evoked neurotransmitter release, the mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cd1b26aeb643ea35e10560ef321b68
https://doi.org/10.1113/jp282601
https://doi.org/10.1113/jp282601
Autor:
Jennifer L. Peotter, Iryna Pustova, Molly M. Lettman, Shalini Shatadal, Mazdak M. Bradberry, Allison D. Winter-Reed, Maya Charan, Erin E. Sharkey, James R. Alvin, Alyssa M. Bren, Annika K. Oie, Edwin R. Chapman, M. Shahriar Salamat, Anjon Audhya
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Molecular pathways that intrinsically regulate neuronal maintenance are poorly understood, but rare pathogenic mutations that underlie neurodegenerative disease can offer important insights into the mechanisms that facilitate lifelong neuronal functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257be3c78887bd992d8f7f1afdaff0e5
https://doi.org/10.1073/pnas.2210649119
https://doi.org/10.1073/pnas.2210649119
Autor:
Mazdak M. Bradberry, Trenton M. Peters-Clarke, Evgenia Shishkova, Edwin R. Chapman, Joshua J. Coon
At neuronal synapses, synaptic vesicles (SVs) require glycoproteins for normal trafficking, and N-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs. The molecular compositions of SV N-glycans, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::306f8a47f168b889c5d71eddbff3d3c7
https://doi.org/10.1101/2022.07.06.499060
https://doi.org/10.1101/2022.07.06.499060
Publikováno v:
JAMA Psychiatry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48de68f16950d29e354059d826dbac40
https://europepmc.org/articles/PMC10039620/
https://europepmc.org/articles/PMC10039620/
Autor:
Kevin C. Courtney, Lanxi Wu, Taraknath Mandal, Mark Swift, Zhao Zhang, Mohammad Alaghemandi, Zhenyong Wu, Mazdak M. Bradberry, Claire Deo, Luke D. Lavis, Niels Volkmann, Dorit Hanein, Qiang Cui, Huan Bao, Edwin R. Chapman
Publikováno v:
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, 2022, 29 (2), pp.97-107. ⟨10.1038/s41594-021-00716-0⟩
Nat Struct Mol Biol
Nature Structural and Molecular Biology, 2022, 29 (2), pp.97-107. ⟨10.1038/s41594-021-00716-0⟩
Nat Struct Mol Biol
International audience; Neurotransmitter release is mediated by proteins that drive synaptic vesicle fusion with the presynaptic plasma membrane. While soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs) form the core of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fec339b9d0b0a4c70e875f89447ebfb
https://hal.science/hal-04133469
https://hal.science/hal-04133469
Autor:
Mazdak M. Bradberry, Shweta Mishra, Zhao Zhang, Lanxi Wu, Justin M. McKetney, Martha M. Vestling, Joshua J. Coon, Edwin R. Chapman
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 42(17)
Current methods to isolate synaptic vesicles (SVs), the organellar quanta of synaptic transmission, require highly specialized materials and up to 24 h. These technical obstacles have thus far limited the study of SVs in models of synaptic function a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef696280176f66f5faa1ca72585ffb09
https://pubmed.ncbi.nlm.nih.gov/35296545
https://pubmed.ncbi.nlm.nih.gov/35296545
Publikováno v:
J Biol Chem
Exocytosis mediates the release of neurotransmitters and hormones from neurons and neuroendocrine cells. Tandem C2 domain proteins in the synaptotagmin (syt) and double C2 domain (Doc2) families regulate exocytotic membrane fusion via direct interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7388a260315aa9dd37910168cdf50f56
https://doi.org/10.1074/jbc.ra119.007929
https://doi.org/10.1074/jbc.ra119.007929
Autor:
Edwin R. Chapman, Prabhodh S. Abbineni, Jefferson D. Knight, Kevin P. Bohannon, Hai Lin, Arun Anantharam, Tejeshwar C. Rao, Sherleen Tran, Michael W. Schmidtke, Mazdak M. Bradberry, Nara L. Chon, Mounir Bendahmane
Publikováno v:
Molecular Biology of the Cell
This study provides novel mechanistic insights into how Syt-1 and Syt-7 C2B domains regulate the later stages of exocytosis. We show that small structural differences within this region exert significant effects on fusion pore properties. We propose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295d5eb5465a0a72f78bd24c4999f39c
http://europepmc.org/articles/PMC5905296
http://europepmc.org/articles/PMC5905296