Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mayya Shveygert"'
Autor:
Xin Zhou, Gopika G. Nair, Holger A. Russ, Cassandra D. Belair, Mei-Lan Li, Mayya Shveygert, Matthias Hebrok, Robert Blelloch
Publikováno v:
Stem Cell Reports, Vol 14, Iss 1, Pp 9-20 (2020)
Summary: Differentiation of human embryonic stem cells into pancreatic β cells holds great promise for the treatment of diabetes. Recent advances have led to the production of glucose-responsive insulin-secreting cells in vitro, but resulting cells
Externí odkaz:
https://doaj.org/article/24b90ec89952421982da2c90744377f2
Autor:
Gopika G. Nair, Cassandra D. Belair, Matthias Hebrok, Robert Blelloch, Mei-Lan Li, Xin Zhou, Mayya Shveygert, Holger A. Russ
Publikováno v:
Stem cell reports, vol 14, iss 1
Stem Cell Reports, Vol 14, Iss 1, Pp 9-20 (2020)
Stem Cell Reports
Stem Cell Reports, Vol 14, Iss 1, Pp 9-20 (2020)
Stem Cell Reports
Summary Differentiation of human embryonic stem cells into pancreatic β cells holds great promise for the treatment of diabetes. Recent advances have led to the production of glucose-responsive insulin-secreting cells in vitro, but resulting cells r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8f8e6dcf3757b5890f17d765718961
https://escholarship.org/uc/item/4343r09j
https://escholarship.org/uc/item/4343r09j
Autor:
Holger A Russ, Audrey V Parent, Jennifer J Ringler, Thomas G Hennings, Gopika G Nair, Mayya Shveygert, Tingxia Guo, Sapna Puri, Leena Haataja, Vincenzo Cirulli, Robert Blelloch, Greg L Szot, Peter Arvan, Matthias Hebrok
Publikováno v:
The EMBO Journal. 34:1759-1772
Methods are provided for the simple, fast, effective and safe directed differentiation of embryonic stem cells into pancreatic beta-like cells secreting insulin in response to glucose levels. The cells are useful transplant therapeutics for diabetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e45334c58e9c6e76fab4e329b3e9659b
https://doi.org/10.15252/embj.201591058
https://doi.org/10.15252/embj.201591058
Publikováno v:
Molecular and Cellular Biology. 33:127-135
The p38α to p38δ mitogen-activated protein kinases (MAPKs) are central regulatory nodes coordinating acute stress and inflammatory responses. Their activation leads to rapid adjustment of protein synthesis, for instance translational induction of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fa6ef63a893f51fd0588c6d9541b28
https://doi.org/10.1128/mcb.00695-12
https://doi.org/10.1128/mcb.00695-12
Publikováno v:
Future Virology. 6:1045-1058
In cancerous cells, physiologically tight regulation of protein synthesis is lost, contributing to uncontrolled growth and proliferation. We describe a novel experimental cancer therapy approach based on genetically recombinant poliovirus that target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89b9503edbd040b1aa4c260c2f59f90
https://doi.org/10.2217/fvl.11.76
https://doi.org/10.2217/fvl.11.76
Publikováno v:
Molecular and Cellular Biology. 30:5160-5167
The m(7)G cap binding protein eukaryotic initiation factor 4E (eIF4E) is a rate-limiting determinant of protein synthesis. Elevated eIF4E levels, commonly associated with neoplasia, promote oncogenesis, and phosphorylation of eIF4E at Ser209 is criti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70a4d6ffd8decc136e5c078e5f68f9c
https://doi.org/10.1128/mcb.00448-10
https://doi.org/10.1128/mcb.00448-10
Autor:
Constanze Kaiser, Shelton S. Bradrick, Mayya Shveygert, Elena Y. Dobrikova, Matthias Gromeier
Publikováno v:
RNA. 13:1582-1593
The 3′ poly(A) tail present on the majority of mature eukaryotic mRNAs is an important regulator of protein synthesis and mRNA stability. The poly(A) tail improves the efficiency of translation initiation through recruitment of PABP, enabling its i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59929776b32ba1f06ec30dc9d293a21
https://doi.org/10.1261/rna.556107
https://doi.org/10.1261/rna.556107
Autor:
Darell D. Bigner, Vidyalakshmi Chandramohan, Mayya Shveygert, Elena Y. Dobrikova, Michael C. Brown, Shelton S. Bradrick, Jeffrey D. Bryant, Matthias Gromeier
Publikováno v:
Journal of virology. 88(22)
Protein synthesis, the most energy-consuming process in cells, responds to changing physiologic priorities, e.g., upon mitogen- or stress-induced adaptations signaled through the mitogen-activated protein kinases (MAPKs). The prevailing status of pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ecf3295982064205a43b861c64e020
https://pubmed.ncbi.nlm.nih.gov/25187541
https://pubmed.ncbi.nlm.nih.gov/25187541
Publikováno v:
Molecular and cellular biology. 34(3)
During mitosis, global translation is suppressed, while synthesis of proteins with vital mitotic roles must go on. Prior evidence suggests that the mitotic translation shift involves control of initiation. Yet, no signals specifically targeting trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b90067791ebd54552f641ec2dc423bb
https://pubmed.ncbi.nlm.nih.gov/24248602
https://pubmed.ncbi.nlm.nih.gov/24248602
Signal transduction through mitogen-activated protein kinases (MAPKs) is implicated in growth and proliferation control through translation regulation and involves posttranslational modification of translation initiation factors. For example, converg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7004d4d6c694719ac3117ac71d0fe21
https://europepmc.org/articles/PMC3133411/
https://europepmc.org/articles/PMC3133411/