Výsledky vyhledávání - "Mayurranjan S Mitra"

Akademický článek

Complex interplay between the lipin 1 and the hepatocyte nuclear factor 4 α (HNF4α) pathways to regulate liver lipid metabolism.

Autor: Zhouji Chen, Matthew C Gropler, Mayurranjan S Mitra, Brian N Finck

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e51320 (2012)

Lipin 1 is a bifunctional protein that serves as a metabolic enzyme in the triglyceride synthesis pathway and regulates gene expression through direct protein-protein interactions with DNA-bound transcription factors in liver. Herein, we demonstrate

Externí odkaz: https://doaj.org/article/e720c35a403f4a10a193e6087567e78b

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Akademický článek

Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice

Autor: George G. Schweitzer, Zhouji Chen, Connie Gan, Kyle S. McCommis, Nisreen Soufi, Roman Chrast, Mayurranjan S. Mitra, Kui Yang, Richard W. Gross, Brian N. Finck

Publikováno v: Journal of Lipid Research, Vol 56, Iss 4, Pp 848-858 (2015)

Lipin proteins (lipin 1, 2, and 3) regulate glycerolipid homeostasis by acting as phosphatidic acid phosphohydrolase (PAP) enzymes in the TG synthesis pathway and by regulating DNA-bound transcription factors to control gene transcription. Hepatic PA

Externí odkaz: https://doaj.org/article/2459d724c88541a18ee0c839a3ff7076

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Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice

Autor: Min You, Xiaomei Liang, Roman Chrast, Brian N. Finck, Ming Hu, Mayurranjan S. Mitra, Karim Nadra, Hu-Quan Yin, Joanne M. Ajmo

Publikováno v: Hepatology. 58:1953-1963

Lipin-1 regulates lipid metabolism by way of its function as an enzyme in the triglyceride synthesis pathway and as a transcriptional coregulatory protein and is highly up-regulated in alcoholic fatty liver disease. In the present study, using a live

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e70ac6e8adfb2d1257353dc9f153c756
https://doi.org/10.1002/hep.26589

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Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation

Autor: Karim Nadra, Mayurranjan S. Mitra, Roman Chrast, Kari T. Chambers, Xiong Su, Hongmei Ren, Zhouji Chen, Brian N. Finck, Samuel Klein, Andrew J. Morris, Thurl E. Harris, Angela M. Hall

Publikováno v: Proceedings of the National Academy of Sciences. 110:642-647

Lipin 1 is a coregulator of DNA-bound transcription factors and a phosphatidic acid (PA) phosphatase (PAP) enzyme that catalyzes a critical step in the synthesis of glycerophospholipids. Lipin 1 is highly expressed in adipocytes, and constitutive los

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4f0a0e2d030d9d335ec6f510e62437
https://doi.org/10.1073/pnas.1213493110

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Insulin Resistance and Metabolic Derangements in Obese Mice Are Ameliorated by a Novel Peroxisome Proliferator-activated Receptor γ-sparing Thiazolidinedione

Autor: Nathan Qi, Mayurranjan S. Mitra, William G. McDonald, Angela M. Hall, Brian N. Finck, Kari T. Chambers, Rolf F. Kletzien, Patrick A. Vigueira, Zhouji Chen, Jerry R. Colca

Publikováno v: Journal of Biological Chemistry. 287:23537-23548

Currently approved thiazolidinediones (TZDs) are effective insulin-sensitizing drugs that may have efficacy for treatment of a variety of metabolic and inflammatory diseases, but their use is limited by side effects that are mediated through ectopic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0412c9a0bd54535689eb4b9b146f7ec5
https://doi.org/10.1074/jbc.m112.363960

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Regulation of hepatic lipin-1 by ethanol: Role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice

Autor: Xiaomei Liang, Feng-Ming Wang, Ray R. Zhang, David A. Mitchell, Ming Hu, Christopher Q. Rogers, Min You, Brian N. Finck, Xin Li, Mayurranjan S. Mitra

Publikováno v: Hepatology. 55:437-446

Lipin-1 is a protein that exhibits dual functions as a phosphatidic acid phosphohydrolase (PAP) enzyme in the triglyceride synthesis pathways and a transcriptional co-regulator. Our previous studies have shown that ethanol causes fatty liver by activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89dc7db29925dab7d31417b124b979ce
https://doi.org/10.1002/hep.24708

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Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axis

Autor: Brian N. Finck, Xiaowei Wang, Mayurranjan S. Mitra, Janice M. Huss, Xiong Su, Patrick Y. Jay, Joel D. Schilling

Publikováno v: Journal of Molecular and Cellular Cardiology. 51:120-128

Lipin family proteins (lipin 1, 2, and 3) are bifunctional intracellular proteins that regulate metabolism by acting as coregulators of DNA-bound transcription factors and also dephosphorylate phosphatidate to form diacylglycerol [phosphatidate phosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346b1ae80e2847a43c6773b7c00bbceb
https://doi.org/10.1016/j.yjmcc.2011.04.009

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High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity

Autor: Brent White, Mayurranjan S. Mitra, Shashikiran Donthamsetty, Harihara M. Mehendale

Publikováno v: Toxicology and Applied Pharmacology. 231:413-422

Often, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d43422960146f38b3a8bd177f6ec41
https://doi.org/10.1016/j.taap.2008.05.006

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