Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mayur S. Mitra"'
Autor:
Phyllis Chan, Han Ting Ding, Bianca M. Liederer, Jialin Mao, Paula Belloni, Liuxi Chen, Simon S. Gao, Victory Joseph, Xiaoying Yang, Joseph S. Lin, Mayur S. Mitra, Wendy S. Putnam, Angelica Quartino, Rebecca N. Bauer, Lin Pan
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1945-1954 (2021)
Abstract GDC‐0334 is a novel small molecule inhibitor of transient receptor potential cation channel member A1 (TRPA1), a promising therapeutic target for many nervous system and respiratory diseases. The pharmacokinetic (PK) profile and pharmacody
Externí odkaz:
https://doaj.org/article/38338915571446a38eeb11b03b47d34b
Autor:
Han Ting Ding, Wendy S. Putnam, Simon S. Gao, Joseph Lin, Bianca M. Liederer, Jialin Mao, Angelica Quartino, Victory Joseph, Xiaoying Yang, Liuxi Chen, Paula Belloni, Phyllis Chan, Rebecca N. Bauer, Mayur S. Mitra, Lin Pan
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1945-1954 (2021)
Clinical and Translational Science
Clinical and Translational Science
GDC‐0334 is a novel small molecule inhibitor of transient receptor potential cation channel member A1 (TRPA1), a promising therapeutic target for many nervous system and respiratory diseases. The pharmacokinetic (PK) profile and pharmacodynamic (PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14caea2d2691c3e776c7ba0522c5ea6
https://doaj.org/article/38338915571446a38eeb11b03b47d34b
https://doaj.org/article/38338915571446a38eeb11b03b47d34b
Autor:
Yan Wu, Jean-Michel Vernes, Wei-Ching Liang, Karla Lancaster, Melissa Schutten, Y. Gloria Meng, Gopinath S. Palanisamy, Rutwij A. Dave, Matthew S Holdren, Adeyemi O Adedeji, Fiona Zhong, Mayur S. Mitra, Shannon J. Turley
Publikováno v:
Toxicological Sciences. 175:24-34
Transforming growth factor β (TGFβ) signaling has been recently shown to reduce antitumor response to PD-L1 blockade, leading to a renewed enthusiasm in developing anti-TGFβ therapies for potential combination with cancer immunotherapy agents. Inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93edf8656b6bd4003a8a622169a138a7
https://doi.org/10.1093/toxsci/kfaa024
https://doi.org/10.1093/toxsci/kfaa024
Publikováno v:
Toxicologic pathology. 49(3)
Long-acting delivery platforms for intravitreal therapies are an active area of research in ophthalmic drug development. The aim of these platforms is to decrease the burden of intravitreal therapies for patients, by increasing the period between int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1320087c877d1d2b0f0a922b576da85
https://pubmed.ncbi.nlm.nih.gov/32975492
https://pubmed.ncbi.nlm.nih.gov/32975492
Autor:
Evan A. Thackaberry, Mayur S. Mitra, Lakshmanan Thiruneelakantapillai, Brad Holub, Steven DeMarco
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 117
Novel peptide drugs continue to gain interest as effective modalities against previously undruggable targets. As with any other technology, development and safety assessment of peptides presents with various complex challenges. Additionally, there is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018d20dac202dafd143e2d03bbc8ad1e
https://pubmed.ncbi.nlm.nih.gov/32827570
https://pubmed.ncbi.nlm.nih.gov/32827570
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781071601709
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1b10acaf613d0991449c34dfadb0ee4
https://doi.org/10.1007/978-1-0716-0171-6_12
https://doi.org/10.1007/978-1-0716-0171-6_12
Autor:
Joel P. Bercu, Richard Hutchinson, Kaushik Datta, John C. Pettersen, John Nicolette, Teresa C. Wegesser, Mayur S. Mitra
Publikováno v:
Regulatory Toxicology and Pharmacology. 122:104895
As per the ICH Q3A(R2) and Q3B(R2) regulatory guidelines, safety studies may be needed when an impurity in new drug substances or products is above the qualification threshold, and such qualification studies should be conducted in one nonclinical spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f58ccaac1578797cdabf73cd17ec62
https://doi.org/10.1016/j.yrtph.2021.104895
https://doi.org/10.1016/j.yrtph.2021.104895