Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Mayur Madhavan"'
Autor:
Angela M. Lager, Olivia G. Corradin, Jared M. Cregg, Matthew S. Elitt, H. Elizabeth Shick, Benjamin L. L. Clayton, Kevin C. Allan, Hannah E. Olsen, Mayur Madhavan, Paul J. Tesar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
The isolation and propagation of oligodendroglial cells from postnatal animals can be impractical for functional genetic studies. This study highlights the potential of a new approach to rapidly generate oligodendrocytes and their progenitors from mo
Externí odkaz:
https://doaj.org/article/71dbdedc40fa404b962276780906a9a8
Autor:
Matthew S. Elitt, H. Elizabeth Shick, Mayur Madhavan, Kevin C. Allan, Benjamin L.L. Clayton, Chen Weng, Tyler E. Miller, Daniel C. Factor, Lilianne Barbar, Baraa S. Nawash, Zachary S. Nevin, Angela M. Lager, Yan Li, Fulai Jin, Drew J. Adams, Paul J. Tesar
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 711-726 (2018)
Summary: Pelizaeus-Merzbacher disease (PMD) is a fatal X-linked disorder caused by loss of myelinating oligodendrocytes and consequent hypomyelination. The underlying cellular and molecular dysfunctions are not fully defined, but therapeutic enhancem
Externí odkaz:
https://doaj.org/article/85ceab688bb44f7d8336a4d35cb11973
Autor:
Erin F. Cohn, Benjamin L.L. Clayton, Mayur Madhavan, Sara Yacoub, Yuriy Federov, Katie Paul-Friedman, Timothy J. Shafer, Paul J. Tesar
Publikováno v:
bioRxiv
Exposure to environmental chemicals can impair neurodevelopment1–4. Oligodendrocytes that wrap around axons to boost neurotransmission may be particularly vulnerable to chemical toxicity as they develop throughout fetal development and into adultho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64e8fc17dd38c4cfb424f9da076e392
https://doi.org/10.1101/2023.02.10.528042
https://doi.org/10.1101/2023.02.10.528042
Publikováno v:
Cereb Cortex
Progenitors in the dorsal lateral ganglionic eminence (dLGE) are known to give rise to olfactory bulb (OB) interneurons and intercalated cells (ITCs) of the amygdala. The dLGE enriched transcription factor Sp8 is required for the normal generation of
Autor:
Ronald A. Conlon, Berit Powers, Matthew S. Elitt, Daniela Schlatzer, H. Elizabeth Shick, Yuka Maeno-Hikichi, Lilianne Barbar, David F. LePage, Weihong Jiang, Hannah E. Olsen, Hien T Zhao, Stevephen Hung, Adam Swayze, Frank Rigo, Paul J. Tesar, Kevin C. Allan, Zachary S. Nevin, Baraa S. Nawash, Masahiro Hitomi, Artur S. Gevorgyan, Mayur Madhavan
Publikováno v:
Nature
Mutations in PLP1, the gene that encodes proteolipid protein (PLP), result in failure of myelination and neurological dysfunction in the X-chromosome-linked leukodystrophy Pelizaeus–Merzbacher disease (PMD)1,2. Most PLP1 mutations, including point
Autor:
Ilya Bederman, Benjamin L.L. Clayton, Erin F. Cohn, Marissa A. Scavuzzo, Mayur Madhavan, Artur S. Gevorgyan, Lucille R. Hu, Kevin C. Allan, Paul J. Tesar, Andrew R. Morton, Stevephen Hung, Cynthia F. Bartels
Publikováno v:
Cell Stem Cell
Mammalian cells respond to insufficient oxygen through transcriptional regulators called hypoxia-inducible factors (HIFs). Although transiently protective, prolonged HIF activity drives distinct pathological responses in different tissues. Using a mo
Autor:
Yan Li, Matthew S. Elitt, Zachary S. Nevin, Paul J. Tesar, Angela M. Lager, H. Elizabeth Shick, Chen Weng, Drew J. Adams, Mayur Madhavan, Tyler E. Miller, Kevin C. Allan, Lilianne Barbar, Fulai Jin, Daniel C. Factor, Baraa S. Nawash, Benjamin L.L. Clayton
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 711-726 (2018)
Summary: Pelizaeus-Merzbacher disease (PMD) is a fatal X-linked disorder caused by loss of myelinating oligodendrocytes and consequent hypomyelination. The underlying cellular and molecular dysfunctions are not fully defined, but therapeutic enhancem
Autor:
William K. Wilson, Matthew S. Elitt, Dharmaraja Allimuthu, Paul J. Tesar, Ilya Bederman, Mayur Madhavan, Franz Bracher, H. Elizabeth Shick, Martin Giera, Joel L. Sax, Jing Jin, Yuriy Fedorov, Eric Garrison, Zita Hubler, Drew J. Adams, Kevin C. Allan, Robert H. Miller, Daniel C. Factor, Matthew A. Thompson, Molly Karl, Zachary S. Nevin
Publikováno v:
Nature, 560(7718), 372
Nature
Nature
Regeneration of myelin is mediated by oligodendrocyte progenitor cells (OPCs), an abundant stem cell population in the CNS and the principal source of new myelinating oligodendrocytes. Loss of myelin-producing oligodendrocytes in the central nervous
Autor:
Lilianne Barbar, Robert H. Miller, Benjamin L.L. Clayton, Valentina Fossati, Mayur Madhavan, Kevin C. Allan, H. Elizabeth Shick, Eric Garrison, Paul J. Tesar, Zachary S. Nevin, Tanya Jain, Cheryl Clarkson-Paredes, Panagiotis Douvaras, Daniel C. Factor, Molly Karl
Publikováno v:
Nature methods
Organoid technologies provide an accessible system to examine cellular composition, interactions, and organization in the developing human brain, but previously have lacked oligodendrocytes, the myelinating glia of the central nervous system. Here we
Autor:
Paul J. Tesar, Robert T. Karl, Drew J. Adams, Tyler E. Miller, Ranjan Dutta, Gursimran Dhillon, Olivia Corradin, An T. Hoang, Parker A. Hall, Bruna R. Lima, Sagar Nisraiyya, Alexey Kozlenkov, Mayur Madhavan, Anna M. Barbeau, Christina Volsko, Cynthia F. Bartels, Peter C. Scacheri, Stella Dracheva, Fadi J. Najm, Kathryn E.A. Hazel, Daniel C. Factor, Zachary S. Nevin
Publikováno v:
SSRN Electronic Journal.
Multiple sclerosis (MS) is an autoimmune disease characterized by attack on oligodendrocytes within the central nervous system (CNS). Despite widespread use of immunomodulatory therapies, patients face progressive disability due to failure of myelin