Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mayur K. Ladumor"'
Autor:
Flavia Storelli, Mayur K. Ladumor, Xiaomin Liang, Yurong Lai, Paresh P. Chothe, Osatohanmwen J. Enogieru, Raymond Evers, Jashvant D. Unadkat
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 1, Pp 118-131 (2024)
Abstract Hepatic impairment (HI) moderately (10‐fold) for drugs that are also substrates of cytochrome P450 (CYP) 3A enzymes. Using the extended clearance model, through simulations, we identified the ratio of sinusoidal efflux clearance (CL) over
Externí odkaz:
https://doaj.org/article/c097d02f10554901a6c847d7d9e18162
Autor:
Mayur K. Ladumor, Flavia Storelli, Xiaomin Liang, Yurong Lai, Osatohanmwen J. Enogieru, Paresh P. Chothe, Raymond Evers, Jashvant D. Unadkat
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 2, Pp 261-273 (2023)
Abstract Physiologically based pharmacokinetic models, populated with drug‐metabolizing enzyme and transporter (DMET) abundance, can be used to predict the impact of hepatic impairment (HI) on the pharmacokinetics (PK) of drugs. To increase confide
Externí odkaz:
https://doaj.org/article/c46951343ed24a8cbfdc20b789315bfd
Autor:
Revathi Chapa, Cindy Yanfei Li, Abdul Basit, Aarzoo Thakur, Mayur K Ladumor, Sheena Sharma, Saranjit Singh, Arzu Selen, Bhagwat Prasad
Publikováno v:
ACS Omega, Vol 5, Iss 51, Pp 32939-32950 (2020)
Externí odkaz:
https://doaj.org/article/148789a0799144c6bba30970a6065364
Publikováno v:
Drug Metabolism and Disposition. 51:743-752
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f170943c55c33b2fd665c2c7182f65f
https://doi.org/10.1124/dmd.122.001128
https://doi.org/10.1124/dmd.122.001128
Autor:
Mayur K. Ladumor, Flavia Storelli, Xiaomin Liang, Yurong Lai, Osatohanmwen J. Enogieru, Paresh P. Chothe, Raymond Evers, Jashvant D. Unadkat
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 12:261-273
Physiologically based pharmacokinetic models, populated with drug-metabolizing enzyme and transporter (DMET) abundance, can be used to predict the impact of hepatic impairment (HI) on the pharmacokinetics (PK) of drugs. To increase confidence in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5fc28686d8078da062e80b2c4f9e96
https://doi.org/10.1002/psp4.12901
https://doi.org/10.1002/psp4.12901
Autor:
Dilip Kumar Singh, Ankit Balhara, Mayur K. Ladumor, Manikandan Ramalingam, Hemant Bhutani, Bhagwat Prasad, Moolchand Kurmi, Ravi P. Shah, Amrit Paudel, Sheena Sharma, T. Thanga Mariappan, Dattatray Modhave, Surapuraju Pavankumarraju
Publikováno v:
Journal of Pharmaceutical Sciences. 111:1224-1231
This commentary presents contributions and accomplishments of Professor Saranjit Singh, National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, India, to pharmaceutical research and education. Prof. Singh completed his success
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d7c843d14363b6b95b6f9530cbf3f1
https://doi.org/10.1016/j.xphs.2021.10.024
https://doi.org/10.1016/j.xphs.2021.10.024
Autor:
Ankit, Balhara, Mayur K, Ladumor, Rakesh P, Nankar, Samiulla Dodheri, Syed, Sanjeev, Giri, Bhagwat, Prasad, Saranjit, Singh
Publikováno v:
Pharmaceutical Research. 39:677-689
Ethambutol (EMB) is a first-line anti-tubercular drug that is known to cause optic neuropathy. The exact mechanism of its eye toxicity is unknown; however, proposition is metal chelating effect of both EMB and its metabolite 2,2'-(ethylenediamino)-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded0952caa7f773d71e9e557649558d1
https://doi.org/10.1007/s11095-022-03227-9
https://doi.org/10.1007/s11095-022-03227-9
Autor:
Mayur K. Ladumor, Bhagwat Prasad, Aarzoo Thakur, Revathi Chapa, Sheena Sharma, Arzu Selen, Abdul Basit, Cindy Yanfei Li, Saranjit Singh
Publikováno v:
ACS Omega, Vol 5, Iss 51, Pp 32939-32950 (2020)
ACS Omega
ACS Omega
Furosemide is a widely used diuretic for treating excessive fluid accumulation caused by disease conditions like heart failure and liver cirrhosis. Furosemide tablet formulation exhibits variable pharmacokinetics (PK) with bioavailability ranging fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109414fefafd772ef477dc036759449d
https://doaj.org/article/148789a0799144c6bba30970a6065364
https://doaj.org/article/148789a0799144c6bba30970a6065364
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 50(5)
Pregnant women are frequently prescribed drugs to treat chronic diseases such as human immunodeficiency virus infection, but little is known about the benefits and risks of these drugs to the fetus that are driven by fetal drug exposure. The latter c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ac2fbfbd81926c7de3be8eb998cee9
https://pubmed.ncbi.nlm.nih.gov/35149540
https://pubmed.ncbi.nlm.nih.gov/35149540
Autor:
Flavia Storelli, Mengyue Yin, Aditya R. Kumar, Mayur K. Ladumor, Raymond Evers, Paresh P. Chothe, Osatohanmwen J. Enogieru, Xiaomin Liang, Yurong Lai, Jashvant D. Unadkat
Publikováno v:
Pharmacology & Therapeutics. 238:108271
Predicting transporter-based drug clearance (CL) and tissue concentrations (TC) in humans is important to reduce the risk of failure during drug development. In addition, when transporters are present at the tissue:blood interface (e.g., in the liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f667706a2439ebd33ac63a8d66caee63
https://doi.org/10.1016/j.pharmthera.2022.108271
https://doi.org/10.1016/j.pharmthera.2022.108271