Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mayumi Tokuhisa"'
Autor:
Kana Miyahara, Naoharu Takano, Yumiko Yamada, Hiromi Kazama, Mayumi Tokuhisa, Hirotsugu Hino, Koji Fujita, Edward Barroga, Masaki Hiramoto, Hiroshi Handa, Masahiko Kuroda, Takashi Ishikawa, Keisuke Miyazawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract BRCA1 is a well-studied tumor suppressor involved in the homologous repair of DNA damage, whereas PINK1, a mitochondrial serine/threonine kinase, is known to be involved in mitochondrial quality control. Genetic mutations of PINK1 and Parkin
Externí odkaz:
https://doaj.org/article/2b53b82c6ae5403ab382220048b0b353
Autor:
Naoharu Takano, Masaki Hiramoto, Yumiko Yamada, Hiroko Kokuba, Mayumi Tokuhisa, Hirotsugu Hino, Keisuke Miyazawa
Publikováno v:
British Journal of Cancer. 128:1838-1849
Background Autophagy plays an important role in tumour cell growth and survival and also promotes resistance to chemotherapy. Hence, autophagy has been targeted for cancer therapy. We previously reported that macrolide antibiotics including azithromy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5b0504bf8c1dce1a1821fa8c6646c1d
https://doi.org/10.1038/s41416-023-02210-4
https://doi.org/10.1038/s41416-023-02210-4
Autor:
Naoharu Takano, Masaya Miyazaki, Ayuka Yokota, Mayumi Tokuhisa, Hirotsugu Hino, Keisuke Miyazawa, Masaki Hiramoto, Hiromi Kazama
Publikováno v:
Biochemical and Biophysical Research Communications. 531:256-263
Sequestosome 1 (p62) is a multifunctional adapter protein involved in various physiological functions, such as selective autophagy and oxidative stress response. Hence, aberrant expression and defective regulation of p62 are thought to lead to the on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160821ae947b34edd4b45448a107e921
https://doi.org/10.1016/j.bbrc.2020.07.058
https://doi.org/10.1016/j.bbrc.2020.07.058
Autor:
Hirotsugu Hino, Mayumi Tokuhisa, Keisuke Miyazawa, Masaki Hiramoto, Naoharu Takano, Jun Takemura, Hiroko Kokuba, Masaya Miyazaki, Hiromi Kazama
Publikováno v:
International Journal of Molecular Medicine
The autophagy‑lysosome system allows cells to adapt to environmental changes by regulating the degradation and recycling of cellular components, and to maintain homeostasis by removing aggregated proteins and defective organelles. Cyclin G‑associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f69d2441574965dc8b7821c0aae365
https://doi.org/10.3892/ijmm.2021.5028
https://doi.org/10.3892/ijmm.2021.5028
Autor:
Keisuke Miyazawa, Hiroshi Handa, Edward Barroga, Koji Fujita, Hiromi Kazama, Kana Miyahara, Masahiko Kuroda, Yumiko Yamada, Hirotsugu Hino, Takashi Ishikawa, Mayumi Tokuhisa, Naoharu Takano, Masaki Hiramoto
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
BRCA1 is a well-studied tumor suppressor involved in the homologous repair of DNA damage, whereas PINK1, a mitochondrial serine/threonine kinase, is known to be involved in mitochondrial quality control. Genetic mutations of PINK1 and Parkin cause au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665f4f21ace9a023062f8f8a0b9e201b
https://doi.org/10.1038/s41598-021-87698-7
https://doi.org/10.1038/s41598-021-87698-7
Autor:
Naoharu Takano, Hiromi Kazama, Keisuke Miyazawa, Takashi Ishikawa, Hiroshi Handa, Edward Barroga, Mayumi Tokuhisa, Hirotsugu Hino, Yumiko Yamada, Masaki Hiramoto, Koji Fujita, Masahiko Kuroda, Kana Miyahara
Publikováno v:
Cancer Research. 80:296-296
The tumor suppressor BRCA1 protein has been implicated in hereditary breast and ovarian cancer syndrome when its gene is mutated. Among the many functions of BRCA1 including DNA repair, transcriptional regulation, cell cycle checkpoint, apoptosis, ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cddd0321d219c89d543b40f9e77b04d
https://doi.org/10.1158/1538-7445.am2020-296
https://doi.org/10.1158/1538-7445.am2020-296
Autor:
Hirotsugu Hino, Naoharu Takano, Yumiko Yamada, Mayumi Tokuhisa, Keisuke Miyazawa, Masaki Hiramoto
Publikováno v:
Cancer Research. 80:1227-1227
Autophagy is a self-digestive cellular mechanism that enables survival under nutrient depleted conditions. In normal cells, autophagy has been known to prevent tumorigenesis by removal of genotoxicity-causing mitochondria, as well as transformed cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0664f45e4fc67b4d05cb223bc9676d6
https://doi.org/10.1158/1538-7445.am2020-1227
https://doi.org/10.1158/1538-7445.am2020-1227
Publikováno v:
Acta crystallographica. Section F, Structural biology communications. 73(Pt 2)
D-Threonine aldolase from the green algaChlamydomonas reinhardtii(CrDTA) catalyzes the interconversion of several β-hydroxy-D-amino acids (e.g.D-threonine) and glycine plus the corresponding aldehydes. Recombinant CrDTA was overexpressed inEscherich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc8581c2ae0013c61c4cc752130ceef
https://pubmed.ncbi.nlm.nih.gov/28177318
https://pubmed.ncbi.nlm.nih.gov/28177318
Autor:
Yuki Hirato, Mayumi Tokuhisa, Hiroyuki Ashida, Katsushi Nishimura, Hiroyuki Tanaka, Minoru Tanigawa
Publikováno v:
Phytochemistry. 135
d-Threonine aldolase (DTA) catalyzes the pyridoxal 5’-phosphate (PLP)-dependent interconversion of d-threonine and glycine plus acetaldehyde. The enzyme is a powerful tool for the stereospecific synthesis of various β-hydroxy amino acids in synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b91e7c8f988534d0db1888ae9b1387
https://pubmed.ncbi.nlm.nih.gov/28038776
https://pubmed.ncbi.nlm.nih.gov/28038776