Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Mayumi Tachibana"'
A Pvs25 mRNA vaccine induces complete and durable transmission-blocking immunity to Plasmodium vivax
Autor:
Nawapol Kunkeaw, Wang Nguitragool, Eizo Takashima, Niwat Kangwanrangsan, Hiromi Muramatsu, Mayumi Tachibana, Tomoko Ishino, Paulo J. C. Lin, Ying K. Tam, Sathit Pichyangkul, Takafumi Tsuboi, Norbert Pardi, Jetsumon Sattabongkot
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract Plasmodium vivax (P. vivax) is the major malaria parasite outside of Africa and no vaccine is available against it. A vaccine that interrupts parasite transmission (transmission-blocking vaccine, TBV) is considered highly desirable to reduce
Externí odkaz:
https://doaj.org/article/6bd36135820a49e28ce8dba3dfe11f1d
Publikováno v:
mSphere, Vol 8, Iss 4 (2023)
ABSTRACT During invasion, Plasmodium parasites secrete proteins from rhoptry and microneme apical end organelles, which have crucial roles in attaching to and invading target cells. A sporozoite stage-specific gene silencing system revealed that rhop
Externí odkaz:
https://doaj.org/article/a309027566ce4609a22632b568bec990
Autor:
Nawapol Kunkeaw, Wang Nguitragool, Eizo Takashima, Niwat Kangwanrangsan, Hiromi Muramatsu, Mayumi Tachibana, Tomoko Ishino, Paulo J. C. Lin, Ying K. Tam, Sathit Pichyangkul, Takafumi Tsuboi, Norbert Pardi, Jetsumon Sattabongkot
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/6021f933132340f7af4cc14704f35b9e
Autor:
Wei-Chiao Huang, Moustafa T. Mabrouk, Luwen Zhou, Minami Baba, Mayumi Tachibana, Motomi Torii, Eizo Takashima, Emily Locke, Jordan Plieskatt, C. Richter King, Camila H. Coelho, Patrick E. Duffy, Carole Long, Takafumi Tsuboi, Kazutoyo Miura, Yimin Wu, Tomoko Ishino, Jonathan F. Lovell
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Co-display of two P. falciparum malaria vaccine antigens (Pfs230D1+ and CSP) on the surface of immunogenic liposomes results in functional immune responses upon immunization of mice and rabbits. Combining both antigens produces immune responses that
Externí odkaz:
https://doaj.org/article/f8e6b970eebc47eab359d0eb8d1b356e
Autor:
Kazutoyo Miura, Eizo Takashima, Thao P. Pham, Bingbing Deng, Luwen Zhou, Wei-Chiao Huang, Ababacar Diouf, Yonas T. Gebremicale, Mayumi Tachibana, Tomoko Ishino, C. Richter King, Jonathan F. Lovell, Carole A. Long, Takafumi Tsuboi
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-10 (2022)
Abstract Pfs230 is a leading malaria transmission blocking vaccine (TBV) candidate. Comprising 3135 amino acids (aa), the large size of Pfs230 necessitates the use of sub-fragments as vaccine immunogens. Therefore, determination of which regions indu
Externí odkaz:
https://doaj.org/article/443d66dfac1e4aaf99ee198dffee8caa
Autor:
Hitoshi Otsuki, Osamu Kaneko, Daisuke Ito, Yoko Kondo, Hideyuki Iriko, Tomoko Ishino, Mayumi Tachibana, Takafumi Tsuboi, Motomi Torii
Publikováno v:
Biomolecules, Vol 13, Iss 3, p 458 (2023)
Plasmodium malaria parasites use erythrocyte-binding-like (EBL) ligands to invade erythrocytes in their vertebrate host. EBLs are released from micronemes, which are secretory organelles located at the merozoite apical end and bind to erythrocyte sur
Externí odkaz:
https://doaj.org/article/4592342b3f984cf09f7710077db0ad83
Autor:
Eizo Takashima, Mayumi Tachibana, Masayuki Morita, Hikaru Nagaoka, Bernard N. Kanoi, Takafumi Tsuboi
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Control measures have significantly reduced malaria morbidity and mortality in the last two decades; however, the downward trends have stalled and have become complicated by the emergence of COVID-19. Significant efforts have been made to develop mal
Externí odkaz:
https://doaj.org/article/b63bc3e9818d45f1932166a67844f8bc
Autor:
Rachaneeporn Jenwithisuk, Niwat Kangwanrangsan, Mayumi Tachibana, Amporn Thongkukiatkul, Hitoshi Otsuki, Jetsumon Sattabongkot, Takafumi Tsuboi, Motomi Torii, Tomoko Ishino
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-15 (2018)
Abstract Background For the success of the malaria control and eradication programme it is essential to reduce parasite transmission by mosquito vectors. In the midguts of mosquitoes fed with parasite-infected blood, sexual-stage parasites fertilize
Externí odkaz:
https://doaj.org/article/4feec7f98c1240dabf4ea99a9e63a47b
Publikováno v:
mSphere, Vol 5, Iss 4 (2020)
ABSTRACT In the Plasmodium life cycle, two infectious stages of parasites, merozoites and sporozoites, share rhoptry and microneme apical structures. A crucial step during merozoite invasion of erythrocytes is the discharge to the host cell membrane
Externí odkaz:
https://doaj.org/article/9c483a5c473245cd8803c461b418c152
Autor:
Naohito Tokunaga, Mamoru Nozaki, Mayumi Tachibana, Minami Baba, Kazuhiro Matsuoka, Takafumi Tsuboi, Motomi Torii, Tomoko Ishino
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
In the Plasmodium lifecycle two infectious stages of parasites, merozoites, and sporozoites, efficiently infect mammalian host cells, erythrocytes, and hepatocytes, respectively. The apical structure of merozoites and sporozoites contains rhoptry and
Externí odkaz:
https://doaj.org/article/c59c37166d4246bca08261494f5949df