Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mayumi, Egawa"'
Autor:
Tomohide Kurahashi, Yuichi Yoshida, Satoshi Ogura, Mayumi Egawa, Kunimaro Furuta, Hayato Hikita, Takahiro Kodama, Ryotaro Sakamori, Shinichi Kiso, Yoshihiro Kamada, I-Ching Wang, Hidetoshi Eguchi, Eiichi Morii, Yuichiro Doki, Masaki Mori, Vladimir V. Kalinichenko, Tomohide Tatsumi, Tetsuo Takehara
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 425-446 (2020)
Background & Aims: Liver inflammation has been recognized as a hallmark of hepatocarcinogenesis. Although Forkhead Box M1 (FoxM1) is a well-defined oncogenic transcription factor that is overexpressed in hepatocellular carcinoma (HCC), its role in li
Externí odkaz:
https://doaj.org/article/5ba2358818af4cb5928d97ec632e1731
Autor:
Mayumi Egawa, Tomohide Kurahashi, Hidetoshi Eguchi, Satoshi Ogura, Yuichi Yoshida, Kunimaro Furuta, Takashi Kizu, Yoshihiro Kamada, Masaki Mori, Mina Hamano, Norihiro Chatani, Shinichi Kiso, Yuichiro Doki, Hayato Hikita, Tetsuo Takehara, Tomohide Tatsumi, Hiroaki Nagano
Publikováno v:
Hepatology Research. 47:1196-1205
AIM Forkhead Box M1 (FoxM1) is a proliferation-specific transcription factor. In this study, we aimed to elucidate the clinicopathological and prognostic values of FoxM1 expression in human hepatocellular carcinoma (HCC) and correlate FoxM1 expressio
Autor:
Soichiro Yoshikawa, Yoshinori Yamanishi, Toshihisa Nagao, Kensuke Miyake, Masatsugu Oh-hora, Louis Peters, Ryota Hashimoto, Takuya Ohta, Hajime Karasuyama, Yohei Kawano, Mayumi Egawa, Takahiro Adachi
Publikováno v:
Science signaling. 12(576)
Basophils have nonredundant roles in various immune responses that require Ca2+ influx. Here, we examined the role of two Ca2+ sensors, stromal interaction molecule 1 and 2 (STIM1 and STIM2), in basophil activation. We found that loss of STIM1, but n
Autor:
Yoshihiro Kamada, Norihiro Chatani, Shinichi Kiso, Mina Hamano, Takayo Takemura, Hisao Ezaki, Satoshi Ogura, Mayumi Egawa, Keigo Nishida, Kunimaro Furuta, Yoshikazu Nakaoka, Tetsuo Takehara, Yuichi Yoshida, Takashi Kizu
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 308:G613-G624
Grb2-associated binder 1 (Gab1) adaptor protein amplifies signals downstream of a broad range of growth factors/receptor tyrosine kinases. Although these signals are implicated in liver fibrogenesis, the role of Gab1 remains unclear. To elucidate the
Autor:
Yoshihiro Kamada, Mayumi Egawa, Norihiro Chatani, Satoshi Ogura, Yuichi Yoshida, Shinichi Kiso, Hisao Ezaki, Kunimaro Furuta, Akihiko Shimono, Takashi Kizu, Mina Hamano, Noriyuki Ouchi, Tetsuo Takehara
Publikováno v:
Liver International. 35:2017-2026
Background & Aims Obesity-related adipocytokine dysregulation is known to accelerate liver fibrosis progression. Recently, a natural Wnt5a inhibitor, secreted frizzled-related protein 5 (Sfrp5), was identified as a novel adipocytokine that has reduce
Autor:
Mayumi Egawa, Hidetoshi Eguchi, Hayato Hikita, Kunimaro Furuta, Masaki Mori, Yoshihiro Kamada, Shinichi Kiso, Hisakazu Ogita, Tomohide Kurahashi, Satoshi Ogura, Yuichi Yoshida, Tetsuo Takehara, Yuichiro Doki, Tomohide Tatsumi
Publikováno v:
Oncotarget
Dysregulation of cell metabolism is a hallmark of cancer. The mevalonate pathway in lipid metabolism has been implicated as a potential target of cancer therapy for hepatocellular carcinoma (HCC). The role of the Forkhead Box M1 (FoxM1) transcription
Autor:
Yoshihiro Kamada, Mayumi Egawa, Kunimaro Furuta, Mina Hamano, Shinichi Kiso, Norihiro Chatani, Hisao Ezaki, Yuichi Yoshida, Takashi Kizu, Tetsuo Takehara
Publikováno v:
Journal of Gastroenterology
Background and aim Impaired fatty liver regeneration has already been reported in many genetic modification models. However, in diet-induced simple hepatic steatosis, which showed similar phenotype with clinical pathology, whether liver regeneration
Autor:
Mayumi, Egawa, Yuichi, Yoshida, Satoshi, Ogura, Tomohide, Kurahashi, Takashi, Kizu, Kunimaro, Furuta, Yoshihiro, Kamada, Norihiro, Chatani, Mina, Hamano, Shinichi, Kiso, Hayato, Hikita, Tomohide, Tatsumi, Hidetoshi, Eguchi, Hiroaki, Nagano, Yuichiro, Doki, Masaki, Mori, Tetsuo, Takehara
Publikováno v:
Hepatology research : the official journal of the Japan Society of Hepatology. 47(11)
Forkhead Box M1 (FoxM1) is a proliferation-specific transcription factor. In this study, we aimed to elucidate the clinicopathological and prognostic values of FoxM1 expression in human hepatocellular carcinoma (HCC) and correlate FoxM1 expression wi
Autor:
Mayumi Egawa, Yoshihiro Kamada, Tetsuo Takehara, Takayo Takemura, Yuichi Yoshida, Takashi Kizu, Kunimaro Furuta, Hisao Ezaki, Norio Hayashi, Norihiro Chatani, Mina Hamano, Shinichi Kiso
Publikováno v:
Hepatology Research. 43:401-412
Aim Many studies indicate an accelerated progression of non-alcoholic steatohepatitis (NASH) in postmenopausal women. Very recently, we reported that estrogen deficiency enhanced the progression of steatohepatitis in mice fed a high fat and high chol
Autor:
Kunimaro Furuta, Shigeki Higashiyama, Yoshihiro Kamada, Yuichi Yoshida, Takashi Kizu, Yukiko Saji, Takayo Takemura, Hisao Ezaki, Norio Hayashi, Eisuke Mekada, Mina Hamano, Norihiro Chatani, Tetsuo Takehara, Shinichi Kiso, Ryo Iwamoto, Mayumi Egawa
Publikováno v:
Hepatology Research. 43:384-393
Aim: We previously demonstrated that heparin-binding epidermal growth factor-like growth factor (HB-EGF) is induced in response to several liver injuries. Because the HB-EGF knockout (KO) mice die in utero or immediately after birth due to cardiac de