Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mayuko Kurobe"'
Autor:
Katsuhiro Konno, Hector F. DeLuca, Mayuko Kurobe, Shojiro Maki, Toshio Okano, Toshie Fujishima, Kimie Nakagawa, Connie M. Smith, Zhaopeng Liu, Daishiro Miura, Manabu Chokki, Hiroaki Takayama, Seiichi Ishizuka
Publikováno v:
Steroids. 66:277-285
All possible A-ring diastereomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) (2) and 20-epi-2-methyl-1alpha,25-dihydroxyvitamin D(3) (3) were synthesized by palladium-catalyzed coupling reaction of A-ring 'enyne' synthons with CD-ring portions. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48360a76d2fc1391ab7639e3102c1112
https://doi.org/10.1016/s0039-128x(00)00141-0
https://doi.org/10.1016/s0039-128x(00)00141-0
Autor:
Mayuko Kurobe, Toshio Okano, Hiroaki Takayama, Katsuhiro Konno, Kimie Nakagawa, Toshie Fujishima
Publikováno v:
Biochemical Pharmacology. 60:1937-1947
1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)) has been shown to modulate not only proliferation and differentiation but also apoptosis of malignant cells, indicating that it would be useful for the treatment of hyperproliferative diseases su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a060bbca140b74ff1896ee5e9fbea95
https://doi.org/10.1016/s0006-2952(00)00486-x
https://doi.org/10.1016/s0006-2952(00)00486-x
Autor:
Toshio Okano, Katsuhiro Konno, Mayuko Kurobe, Kimie Nakagawa, Hiroaki Takayama, Toshie Fujishima
Publikováno v:
Bioorganic & Medicinal Chemistry. 8:123-134
An improved synthesis of the diastereomers of 1alpha,25-dihydroxyvitamin D3 (1) was accomplished utilizing our practical route to the A-ring synthon. We applied this procedure to synthesize for the first time all possible A-ring diastereomers of 20-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f6e785e55f9cba18e042a193409cca
https://doi.org/10.1016/s0968-0896(99)00262-x
https://doi.org/10.1016/s0968-0896(99)00262-x
Autor:
Keiichi Ozono, Mayuko Kurobe, Toshio Okano, Yoshiyuki Ono, Naoko Tsugawa, Kimie Nakagawa, Noboru Kubodera
Publikováno v:
Biological and Pharmaceutical Bulletin. 23:66-71
Biological activities of a series of 2beta-substituted analogues of 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3] were evaluated in vitro in terms of their binding affinity with regard to calf thymus cytosolic vitamin D receptor (VDR) and rat plas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238f804b3321963996ecaeaad67ef1d1
https://doi.org/10.1248/bpb.23.66
https://doi.org/10.1248/bpb.23.66
Autor:
Kimie Nakagawa, Yoshiko Sowa, Mayuko Kurobe, G. Satyanarayana Reddy, Toshio Okano, Mei-Ling Siu–Caldera, Keiichi Ozono, Milan R. Uskokovic
Publikováno v:
Steroids. 66(3-5)
To clarify physiological role of the carbon 3 (C-3) epimerization of 1alpha,25(OH)(2)D(3) and biologic significance of a 3-epi metabolite of 1alpha,25(OH)(2)D(3), we examined biologic activities of the 3-epimers of 1alpha,25(OH)(2)D(3) and 1alpha,25(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3926ee89d5e24bacad17cd31ace7ce
https://pubmed.ncbi.nlm.nih.gov/11179741
https://pubmed.ncbi.nlm.nih.gov/11179741
Autor:
Katsuhiro Konno, Keiichi Ozono, Toshio Okano, Toshie Fujishima, Hiroaki Takayama, Mayuko Kurobe, Kimie Nakagawa
Publikováno v:
Biochemical pharmacology. 59(6)
We evaluated the biological activity of two sets of ring A stereoisomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) (2-methyl-1alpha,25(OH)(2)D(3)) and 2-methyl-20-epi-1alpha, 25-dihydroxyvitamin D(3) (2-methyl-20-epi-1alpha,25(OH)(2)D(3)) in terms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1808f4c72efad337c068eb22fb75925
https://pubmed.ncbi.nlm.nih.gov/10677586
https://pubmed.ncbi.nlm.nih.gov/10677586