Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mayukh Chakrabarti"'
Autor:
Lorenzo I. Finci, Mayukh Chakrabarti, Gulcin Gulten, Joseph Finney, Carissa Grose, Tara Fox, Renbin Yang, Dwight V. Nissley, Frank McCormick, Dominic Esposito, Trent E. Balius, Dhirendra K. Simanshu
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract RAF kinases are integral to the RAS-MAPK signaling pathway, and proper RAF1 folding relies on its interaction with the chaperone HSP90 and the cochaperone CDC37. Understanding the intricate molecular interactions governing RAF1 folding is cr
Externí odkaz:
https://doaj.org/article/e615e38499a94c368dff4f9a7c76932e
Autor:
Katharine M. Wright, Sarah R. DiNapoli, Michelle S. Miller, P. Aitana Azurmendi, Xiaowei Zhao, Zhiheng Yu, Mayukh Chakrabarti, WuXian Shi, Jacqueline Douglass, Michael S. Hwang, Emily Han-Chung Hsiue, Brian J. Mog, Alexander H. Pearlman, Suman Paul, Maximilian F. Konig, Drew M. Pardoll, Chetan Bettegowda, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Shibin Zhou, Sandra B. Gabelli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Specificity remains a major challenge to current therapeutic strategies for cancer. Mutation associated neoantigens (MANAs) are products of genetic alterations, making them highly specific therapeutic targets. MANAs are HLA-presented (pHLA)
Externí odkaz:
https://doaj.org/article/5c61b5ab3e274b5e8cb75d96c8090383
Publikováno v:
The Journal of Physical Chemistry B. 127:1540-1551
The Sodium/Iodide Symporter (NIS), a thirteen-helix transmembrane protein found in the thyroid and other tissues, transports iodide, a required constituent of thyroid hormones T3 and T4. Despite extensive experimental information and clinical data, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed51df9da66252d1f5b31c25f1c85669
https://doi.org/10.1101/2022.10.13.512170
https://doi.org/10.1101/2022.10.13.512170
Autor:
Tihitina Y, Aytenfisu, Hannah M, Campbell, Mayukh, Chakrabarti, L Mario, Amzel, Sandra B, Gabelli
Publikováno v:
Current topics in microbiology and immunology. 436
This chapter is an introduction to phosphoinositide 3-kinases (PI3K), with class I PI3Ks as the central focus. First, the various PI3K isoforms in class I are presented with emphasis on their overall structure, subunits, subunit constitutive domains,
Autor:
Tihitina Y. Aytenfisu, Hannah M. Campbell, Mayukh Chakrabarti, L. Mario Amzel, Sandra B. Gabelli
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783031065651
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51caa599a1faf577be1d6ea690f886da
https://doi.org/10.1007/978-3-031-06566-8_1
https://doi.org/10.1007/978-3-031-06566-8_1
Autor:
Mayukh Chakrabarti, Nancy Carrasco, L. Mario Amzel, Mikel X. Suárez, Andrea Reyna-Neyra, Lara Jung
Publikováno v:
Thyroid.
Background: The sodium/iodide (Na+/I−) symporter (NIS) mediates active transport of I− into the thyroid gland. Mutations in the SLC5A5 gene, which encodes NIS, cause I− transport defects (ITDs)—whi...
Autor:
Andrea, Reyna-Neyra, Lara, Jung, Mayukh, Chakrabarti, Mikel X, Suárez, L Mario, Amzel, Nancy, Carrasco
Publikováno v:
Thyroid
Background: The sodium/iodide (Na(+)/I(−)) symporter (NIS) mediates active transport of I(−) into the thyroid gland. Mutations in the SLC5A5 gene, which encodes NIS, cause I(−) transport defects (ITDs)—which, if left untreated, lead to congen
Publikováno v:
Structure
Class I phosphoinositide-3-kinases (PI3Ks) phosphorylate PIP(2) at its 3′ inositol position to generate PIP(3), a second messenger that influences signaling cascades regulating cellular growth, survival, and proliferation. Previous studies have sug
Publikováno v:
J Phys Chem B
Human HRAS, KRAS, and NRAS genes encode four isoforms of Ras, a p21 GTPase. Mutations in KRAS account for the majority of RAS-driven cancers. The KRAS has two splice variants, K-Ras4A and K-Ras4B. Due to their reversible palmitoylation, K-Ras4A and N