Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Maytham Hussein"'
Autor:
Maytham Hussein, Zetao Sun, Jane Hawkey, Rafah Allobawi, Louise M. Judd, Vincenzo Carbone, Rajnikant Sharma, Varsha Thombare, Mark Baker, Gauri G. Rao, Jian Li, Kathryn E. Holt, Tony Velkov
Publikováno v:
mSystems, Vol 9, Iss 1 (2024)
ABSTRACTNitrofurantoin is a commonly used chemotherapeutic agent in the treatment of uncomplicated urinary tract infections caused by the problematic multidrug resistant Gram-negative pathogen Klebsiella pneumoniae. The present study aims to elucidat
Externí odkaz:
https://doaj.org/article/a020996758a44aecb63f2ae7a08f1d44
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Antibiotic resistance is a top threat to human health and a priority across the globe. This problematic issue is accompanied by the decline of new antibiotics in the pipeline over the past 30 years. In this context, an urgent need to develop new stra
Externí odkaz:
https://doaj.org/article/ed517d4f7d70407991ecf69ae72cf14d
Autor:
Maytham Hussein, Raad Jasim, Hakan Gocol, Mark Baker, Varsha J. Thombare, James Ziogas, Aayush Purohit, Gauri G. Rao, Jian Li, Tony Velkov
Publikováno v:
mSphere, Vol 8, Iss 1 (2023)
ABSTRACT Outer membrane vesicles (OMVs) secreted by Gram-negative bacteria serve as transporters for the delivery of cargo such as virulence and antibiotic resistance factors. OMVs play a key role in the defense against membrane-targeting antibiotics
Externí odkaz:
https://doaj.org/article/728696dabd9445b7b5873a87b878e4c6
Autor:
Maytham Hussein, Sara Oberrauch, Rafah Allobawi, Linda Cornthwaite-Duncan, Jing Lu, Rajnikant Sharma, Mark Baker, Jian Li, Gauri G. Rao, Tony Velkov
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6067-6077 (2022)
There is a dearth of studies focused on understanding pharmacokinetics, pharmacodynamics and toxicodynamics of polymyxins following direct administration to the central nervous system (CNS). In this study, for the first time, untargeted metabolomics
Externí odkaz:
https://doaj.org/article/cc10edd91d624340b9335629527d490a
Autor:
Maytham Hussein, Labell J.M. Wong, Jinxin Zhao, Vanessa E. Rees, Rafah Allobawi, Rajnikant Sharma, Gauri G. Rao, Mark Baker, Jian Li, Tony Velkov
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1077-1087 (2022)
Klebsiella pneumoniae is an opportunistic Gram-negative pathogen causing nosocomial infections. K. pneumoniae rapidly acquires antibiotic resistance and is known as a reservoir for resistance genes. Polymyxins remain effective as a last-line therapy
Externí odkaz:
https://doaj.org/article/af71853ef9784f8183b9c282686bd8b7
Autor:
Maytham Hussein, Xiaohan Hu, Olivia K.A. Paulin, Simon Crawford, Qi Tony Zhou, Mark Baker, Elena K. Schneider-Futschik, Yan Zhu, Jian Li, Tony Velkov
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 2247-2258 (2020)
The status quo for combating uprising antibacterial resistance is to employ synergistic combinations of antibiotics. Nevertheless, the currently available combination therapies are fast becoming untenable. Combining antibiotics with various FDA-appro
Externí odkaz:
https://doaj.org/article/4860056b8b054c22ac7edcdc1048a934
Publikováno v:
Pathogens, Vol 11, Iss 12, p 1420 (2022)
Multidrug-resistant (MDR) Gram-negative pathogens remain an unmet public health threat. In recent times, increased rates of resistance have been reported not only to commonly used antibiotics, but also to the last-resort antibiotics, such as polymyxi
Externí odkaz:
https://doaj.org/article/04d7663a25f14337b6fb8e1d6c5c909f
Autor:
Maytham Hussein, Rafah Allobawi, Irini Levou, Mark A. T. Blaskovich, Gauri G. Rao, Jian Li, Tony Velkov
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 786 (2022)
Polymyxins have resurged as the last-resort antibiotics against multidrug-resistant Acinetobacter baumannii. As reports of polymyxin resistance in A. baumannii with monotherapy have become increasingly common, combination therapy is usually the only
Externí odkaz:
https://doaj.org/article/64ac89b305bd40c3acb3ceb479be1c7d
Autor:
Guido Veit, Ariel Roldan, Mark A. Hancock, Dillon F. Da Fonte, Haijin Xu, Maytham Hussein, Saul Frenkiel, Elias Matouk, Tony Velkov, Gergely L. Lukacs
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
Based on its clinical benefits, Trikafta — the combination of folding correctors VX-661 (tezacaftor), VX-445 (elexacaftor), and the gating potentiator VX-770 (ivacaftor) — was FDA approved for treatment of patients with cystic fibrosis (CF) carry
Externí odkaz:
https://doaj.org/article/b1202180e975466c997feaa921fed85e
Autor:
Maytham Hussein, John A. Karas, Elena K. Schneider-Futschik, Fan Chen, James Swarbrick, Olivia K. A. Paulin, Daniel Hoyer, Mark Baker, Yan Zhu, Jian Li, Tony Velkov
Publikováno v:
mSystems, Vol 5, Iss 3 (2020)
ABSTRACT Antibiotics have served humankind through their use in modern medicine as effective treatments for otherwise fatal bacterial infections. Teixobactin is a first member of newly discovered natural antibiotics that was recently identified from
Externí odkaz:
https://doaj.org/article/4ec53ffd77414313be7feb1fc848292b