Cross-species evolution of a highly potent AAV variant for therapeutic gene transfer and genome editing.

Autor: Gonzalez TJ; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA., Simon KE; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.; North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA., Blondel LO; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Fanous MM; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Roger AL; Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA., Maysonet MS; StrideBio Inc., Research Triangle Park, Durham, NC, USA., Devlin GW; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Smith TJ; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA., Oh DK; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Havlik LP; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Castellanos Rivera RM; StrideBio Inc., Research Triangle Park, Durham, NC, USA., Piedrahita JA; North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA., ElMallah MK; Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA., Gersbach CA; Duke Regeneration Center, Duke University School of Medicine, Durham, NC, USA.; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Asokan A; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA. aravind.asokan@duke.edu.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA. aravind.asokan@duke.edu.; Duke Regeneration Center, Duke University School of Medicine, Durham, NC, USA. aravind.asokan@duke.edu.; Department of Biomedical Engineering, Duke University, Durham, NC, USA. aravind.asokan@duke.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Oct 10; Vol. 13 (1), pp. 5947. Date of Electronic Publication: 2022 Oct 10.