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Akademický článek

A novel microRNA-132-sirtuin-1 axis underlies aberrant B-cell cytokine regulation in patients with relapsing-remitting multiple sclerosis [corrected].

Autor: Yusei Miyazaki, Rui Li, Ayman Rezk, Hétoum Misirliyan, Craig Moore, Nasr Farooqi, Mayra Solis, Lorna Galleguillos Goiry, Omar de Faria Junior, Van Duc Dang, David Colman, Ajit Singh Dhaunchak, Jack Antel, Jennifer Gommerman, Alexandre Prat, Simon Fillatreau, Amit Bar-Or, CIHR/MSSC New Emerging Team Grant in Clinical Autoimmunity, MSSRF Canadian B cells in MS Team

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e105421 (2014)

Clinical trial results demonstrating that B-cell depletion substantially reduces new relapses in patients with multiple sclerosis (MS) have established that B cells play a role in the pathophysiology of MS relapses. The same treatment appears not to

Externí odkaz: https://doaj.org/article/d0ba6ea0eb514d9ea1dbcb02442d3e4d

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Akademický článek

The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.

Autor: Peyman Nakhaei, Thibault Mesplede, Mayra Solis, Qiang Sun, Tiejun Zhao, Long Yang, Tsung-Hsien Chuang, Carl F Ware, Rongtuan Lin, John Hiscott

Publikováno v: PLoS Pathogens, Vol 5, Iss 11, p e1000650 (2009)

The primary role of the innate immune response is to limit the spread of infectious pathogens, with activation of Toll-like receptor (TLR) and RIG-like receptor (RLR) pathways resulting in a pro-inflammatory response required to combat infection. Lim

Externí odkaz: https://doaj.org/article/58c3df36351845568cbe9c4997d3d74f

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Data from Distinct Roles for IFN Regulatory Factor (IRF)-3 and IRF-7 in the Activation of Antitumor Properties of Human Macrophages

Autor: John Hiscott, Margarita Salcedo, Bernard Massie, Rongtuan Lin, Véronique Baron-Bodo, Delphine Goubau, Alessandra Nardin, Mayra Solis, Raphaëlle Romieu-Mourez

When properly activated, macrophages can be tumoricidal, thus making them attractive additions to standard cancer therapies. To this end, tolerance and activity of human autologous IFN-γ-activated macrophages, produced in large scale for clinical us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0fbff1a96bfd77f977f522f2e9e8fff
https://doi.org/10.1158/0008-5472.c.6494991

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IκB Kinase ε-Dependent Phosphorylation and Degradation of X-Linked Inhibitor of Apoptosis Sensitizes Cells to Virus-Induced Apoptosis

Autor: Thibault Mesplède, Peyman Nakhaei, Rongtuan Lin, Suzanne Paz, John Hiscott, Eric Bonneil, Qiang Sun, Mayra Solis

Publikováno v: Journal of Virology. 86:726-737

X-linked inhibitor of apoptosis (XIAP) is a potent antagonist of caspase 3-, 7-, and 9-dependent apoptotic activities that functions as an E3 ubiquitin ligase, and it targets caspases for degradation. In this study, we demonstrate that Sendai virus (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f297bec73a7fc839fdcea35b5d5f5b
https://doi.org/10.1128/jvi.05989-11

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Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7

Autor: Raphaëlle Romieu-Mourez, Douglas W. Leaman, Rongtuan Lin, Mayra Solis, Delphine Goubau, John Hiscott, Thibault Mesplède, Eduardo Hernandez

Publikováno v: European Journal of Immunology. 39:527-540

The immunoregulatory transcriptional modulators - interferon regulatory factor (IRF)-3 and IRF-7 possess similar structural features but distinct gene regulatory potentials. For example, adenovirus mediated transduction of the constitutively active f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c3d39d7fdd5528dc165bae451546ac
https://doi.org/10.1002/eji.200838832

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RIG-I-Mediated Antiviral Signaling Is Inhibited in HIV-1 Infection by a Protease-Mediated Sequestration of RIG-I▿

Autor: Mark A. Wainberg, Mayra Solis, Mohammad Jalalirad, Renée N. Douville, Michael Laughrea, John Hiscott, Meztli Arguello, Judith Lacoste, Peyman Nakhaei, Tiejun Zhao

The rapid induction of type I interferon (IFN) is essential for establishing innate antiviral responses. During infection, cytoplasmic viral RNA is sensed by two DExD/H box RNA helicases, RIG-I and MDA5, ultimately driving IFN production. Here, we de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d2753551e44c7c3fb4eb880d9bc4b8
https://europepmc.org/articles/PMC3020501/

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The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation

Autor: Long Yang, Peyman Nakhaei, John Hiscott, Qiang Sun, Carl F. Ware, Thibault Mesplède, Tiejun Zhao, Rongtuan Lin, Mayra Solis, Tsung-Hsien Chuang

Publikováno v: PLoS Pathogens, Vol 5, Iss 11, p e1000650 (2009)
PLoS Pathogens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a8cd5e805d68cb0258687e55777de2
http://europepmc.org/articles/PMC2766052?pdf=render

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RIG-I has guts: identification of a role for RIG-I in colitis development

Autor: Mayra Solis, John Hiscott, Delphine Goubau

Publikováno v: Cell research. 17(12)

Countries in North America and Europe have the highest incidence of inflammatory disorders of the gastrointestinal tract. The prevalence of inflammatory bowel diseases (IBD), which comprise Crohn's disease (CD) and ulcerative colitis (UC), now ranges

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b296a68c1796e5eb6613259a0e2f06b
https://pubmed.ncbi.nlm.nih.gov/17893708

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Involvement of TBK1 and IKKepsilon in lipopolysaccharide-induced activation of the interferon response in primary human macrophages

Autor: Alessandra Nardin, Ilkka Julkunen, Nathalie Grandvaux, Delphine Goubau, Raphaëlle Romieu-Mourez, Mayra Solis, Margarita Salcedo, John Hiscott, Thibault Mesplède

Publikováno v: European journal of immunology. 37(2)

Interferon (IFN) is an important effector of the innate immune response, induced by different viral or bacterial components through Toll-like receptor-dependent and -independent mechanisms. In human macrophages and macrophage-activated killer cells,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ea63250cb38b06106b44ce96d26d1b
https://pubmed.ncbi.nlm.nih.gov/17236232

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