The Opportunities and Use of Imaging to Measure Target Engagement

Autor: Maynard, Juliana ^*, Hart, Philippa

Publikováno v: In SLAS Discovery February 2020 25(2):127-136

High-resolution 3D visualization of nanomedicine distribution in tumors

Autor: Moss, Jennifer I, Barjat, Hervé, Emmas, Sally-Ann, Strittmatter, Nicole, Maynard, Juliana, Goodwin, Richard J A, Storm, Gert, Lammers, Twan, Puri, Sanyogitta, Ashford, Marianne B, Barry, Simon T, Afd Pharmaceutics, Pharmaceutics

Publikováno v: Theranostics, 10(2), 880-897. Ivyspring International Publisher
Theranostics
Theranostics 10(2), 880-897 (2020). doi:10.7150/thno.37178
Theranostics, 10(2), 880. Ivyspring International Publisher

To improve the clinical translation of anti-cancer nanomedicines, it is necessary to begin building specific insights into the broad concept of the Enhanced Permeability and Retention (EPR) effect, using detailed investigations of the accumulation, d

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https://research.utwente.nl/en/publications/7c37fe8b-a2f7-4549-a388-1fb0309925e1

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The use of F-fluorodeoxyglucose positron emission tomography (F-FDG PET) as a pathway-specific biomarker with AZD8186, a PI3Kβ/δ inhibitor.

Autor: Maynard, Juliana¹ Juliana.maynard@alderleyimaging.com, Emmas, Sally-Ann¹, Blé, Francois-Xavier¹, Barjat, Hervé¹, Lawrie, Emily², Hancox, Urs³, Oakes, Deborah³, Polanska, Urszula³, Barry, Simon³

Publikováno v: EJNMMI Research. 8/11/2016, Vol. 6 Issue 1, p1-10. 10p.

Additional file 2: Figure S2. of The use of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) as a pathway-specific biomarker with AZD8186, a PI3Kβ/δ inhibitor

Autor: Maynard, Juliana, Sally-Ann Emmas, Francois-Xavier Blé, Barjat, Hervé, Lawrie, Emily, Hancox, Urs, Oakes, Deborah, Polanska, Urszula, Barry, Simon

A single dose of AZD8186 (50 mg/kg) results in a non-uniform modulation of biomarkers associated with glucose uptake in different tumour models tested. Phosphorylation of AS160 (Thr642) and expression of Glut-4 and HK2: A) 786-0 model; B) U87-MG mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07de6f1a892a7efd07eb1a7a5b619d9