Výsledky vyhledávání - "Mayke B. Hesselink"

SONU20176289, a compound combining partial dopamine D2 receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression

Autor: Takashi Watanabe, Adina T. Michael-Titus, Thomas Michaelis, Jens Frahm, Monika Albert, Mayke B. Hesselink, Olga Pudovkina, Gregory J. Michael, Eberhard Fuchs, Marieke G. C. van der Hart, Boldizsár Czéh

Publikováno v: European Journal of Pharmacology. 598:43-50

We investigated the efficacy of SONU20176289, a member of a group of novel phenylpiperazine derivatives with a mixed dopamine D(2) receptor partial agonist and specific serotonin reuptake inhibitor (SSRI) activity, in a chronic stress model of depres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062b793279de871b6edb4e0d561dc1d4
https://doi.org/10.1016/j.ejphar.2008.09.006

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Multi-modal characterisation of the neocortical clip model of focal cerebral ischaemia by MRI, behaviour and immunohistochemistry

Autor: John S. Beech, Maria Ashioti, Andrew S. Lowe, Michael Modo, Steve C.R. Williams, Mayke B. Hesselink

Publikováno v: Brain Research. 1145:177-189

The neocortical clip model of focal cerebral ischaemia has previously been used with success in neuroprotection studies. To further improve its translational qualities, we have characterised this model using a combination of serial Magnetic Resonance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b67aac38a45fca61ea634dc4fb6acd
https://doi.org/10.1016/j.brainres.2007.01.111

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In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2(3H)-benzoxazolone, monohydrochloride): a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist

Autor: Jan-Hendrik Reinders, Jeffrey C. Glennon, Guus J. M. van Scharrenburg, Mayke B. Hesselink, Feenstra Roelof W, Long Stephen K, Martina A.W. van der Neut, Andrew C. McCreary, Eric Ronken

Publikováno v: Synapse (New York, N.Y.). 60(8)

Present Parkinson's disease treatment strategies are far from ideal for a variety of reasons; it has therefore been suggested that partial dopamine receptor agonism might be a potential therapeutic approach with potentially fewer side effects. In the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ec2ca1142dc1b475f965450f949ee2
https://pubmed.ncbi.nlm.nih.gov/17001660

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SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4- [5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug

Autor: Charles R. Ashby, Mayke B. Hesselink, Andrew C. McCreary, Jeffrey C. Glennon, Arnoud H.J. Herremans, Herman H. van Stuivenberg, Jan H. Reinders, Zhu Li, Chris G. Kruse, Long Stephen K, Feenstra Roelof W, Herbert Y. Meltzer

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 32(1)

Combined dopamine D(2) receptor antagonism and serotonin (5-HT)(1A) receptor agonism may improve efficacy and alleviate some side effects associated with classical antipsychotics. The present study describes the in vitro and in vivo characterization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b78e78b4a166ab2a410a3c6619df4be
https://pubmed.ncbi.nlm.nih.gov/16710314

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Chronic stress decreases the number of parvalbumin-immunoreactive interneurons in the hippocampus: prevention by treatment with a substance P receptor (NK1) antagonist

Autor: Boldizsár Czéh, María Rosa Simón, Mayke B. Hesselink, Marieke G. C. van der Hart, Eberhard Fuchs, Barthel Schmelting

Publikováno v: Neuropsychopharmacology, 30(1), 67-79. Nature Publishing Group

Previous studies have demonstrated that stress may affect the hippocampal GABAergic system. Here, we examined whether long-term psychosocial stress influenced the number of parvalbumin-containing GABAergic cells, known to provide the most powerful in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03426825773318d65527c7e440664d6c
https://pubmed.ncbi.nlm.nih.gov/15470372

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Tonic inhibition by orphanin FQ/nociceptin of noradrenaline neurotransmission in the amygdala

Autor: Guus J. M. van Scharrenburg, Mayke B. Hesselink, Ben H.C. Westerink, Yukie Kawahara

Publikováno v: European Journal of Pharmacology, 485(1-3), 197-200. ELSEVIER SCIENCE BV

The present microdialysis study investigated whether nociceptin/orphanin FQ exerts a tonic inhibition of the release of noradrenaline in the basolateral nucleus of the amygdala in awake rats. The non-peptide competitive nociceptin/orphanin FQ (N/OFQ)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d333152a955745f9e20c897cdcfa441
https://research.rug.nl/en/publications/2a5522a8-5548-42d4-9111-1cfdb80c020c

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Brain distribution of an uncompetitive NMDA receptor antagonist; comparison to its in vitro potency in electrophysiological studies

Autor: Chris G. Parsons, Christina Wollenburg, Mayke B. Hesselink, Wojciech Danysz

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology. 360(2)

Although the concentration of drugs in brain homogenates is relatively easy to determine, such data are sometimes misleading due to accumulation in intracellular compartments. This is apparent for uncompetitive N-methyl-D-aspartate (NMDA) receptor an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2404ef0d8381441ece2d4f70886b89
https://pubmed.ncbi.nlm.nih.gov/10494883

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Amino-alkyl-cyclohexanes are novel uncompetitive NMDA receptor antagonists with strong voltage-dependency and fast blocking kinetics: in vitro and in vivo characterization

Autor: Bernd Eilbacher, Günter Quack, Mayke B. Hesselink, Wojciech Danysz, Tadeusz Frankiewicz, Peter Spielmanns, Annette Bartmann, Chris G. Parsons

Publikováno v: Neuropharmacology. 38(1)

The present study characterized the in vitro NMDA receptor antagonistic properties of novel amino-alkyl-cyclohexane derivatives and compared these effects with their ability to block excitotoxicity in vitro and MES-induced convulsions in vivo. The 36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb70365de9a3f5a974374593b701734d
https://pubmed.ncbi.nlm.nih.gov/10193901

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