Molecular System Bioenergics of the Heart: Experimental Studies of Metabolic Compartmentation and Energy Fluxes versus Computer Modeling

Autor: Rita Guzun, Minna Karu-Varikmaa, Theo Wallimann, Mayis Aliev, Valdur Saks, Tuuli Kaambre

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2011, 12 (12), pp.9296-331. ⟨10.3390/ijms12129296⟩
International Journal of Molecular Sciences, Vol 12, Iss 12, Pp 9296-9331 (2011)
International Journal of Molecular Sciences, 12 (12)

International audience; In this review we analyze the recent important and remarkable advancements in studies of compartmentation of adenine nucleotides in muscle cells due to their binding to macromolecular complexes and cellular structures, which r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d690d100dfc418bc1ba5670a4c539f40
https://doi.org/10.3390/ijms12129296

Where have the fluxes gone?

Autor: Uwe Schlattner, Petras P. Dzeja, Theo Wallimann, Valdur Saks, Mayis Aliev

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2010, 285 (52), le21; author reply le22. ⟨10.1074/jbc.L110.147116⟩

In a recently published Journal of Biological Chemistry article, Vendelin et al. (1) show that total creatine kinase (CK) unidirectional flux decreased by a factor of 2 at the increased energy demand of Langendorff-perfused heart. These results and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf18b111721198d86202ef0c3bebd6a
https://www.hal.inserm.fr/inserm-00628571

The Creatine Kinase Phosphotransfer Network: Thermodynamic and Kinetic Considerations, the Impact of the Mitochondrial Outer Membrane and Modelling Approaches

Autor: Mayis Aliev, Rita Guzun, Valdur Saks, Marko Vendelin, Peeter Sikk, Uwe Schlattner, Tuuli Kaambre, Theo Wallimann, Tiia Anmann

Publikováno v: Creatine and Creatine Kinase in Health and Disease ISBN: 9781402064852

In this review, we summarize the main structural and functional data on the role of the phosphocreatine (PCr) -- creatine kinase (CK) pathway for compartmentalized energy transfer in cardiac cells. Mitochondrial creatine kinase, MtCK, fixed by cardio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2fcc0629c84e9a23bc5e4c9d8f7bcea
https://doi.org/10.1007/978-1-4020-6486-9_3

Localized Control of Oxidative Phosphorylation within Intracellular Energetic Units in Heart Cells: A Possible Solution of Some Old Problems

Autor: Florence Appaix, Yves Usson, Enn Seppet, Andrey V. Kuznetsov, Jose Olivares, Mayis Aliev, Raimund Margreiter, Karen Guerrero, Valdur Saks

Publikováno v: Signal Transduction and Cardiac Hypertrophy ISBN: 9781461350323

Experimental and in silico studies of regulation of mitochondrial respiration in permeabilized muscle fibers have revealed functional complexes of mitochondria with myofibrils and sarcoplasmic reticulum—intracellular energetic units—as basic patt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d0d6e93aed534e9121a61a102c36d42
https://doi.org/10.1007/978-1-4615-0347-7_20

Metabolic control of contractile performance in isolated perfused rat heart. Analysis of experimental data by reaction:diffusion mathematical model

Autor: Mayis Aliev, Philippe Diolez, Paul Canioni, Simone Bonoron-Adèle, Valdur Saks, Pierre Dos Santos, Peeter Sikk, P. Besse, François Duclos

Publikováno v: Journal of molecular and cellular cardiology. 32(9)

P. Dos Santos, M. K. Aliev, P. Diolez, F. Duclos, P. Besse, S. Bonoron-Adele, P. Sikk, P. Canioni and V. A. Saks. Metabolic Control of Contractile Performance in Isolated Perfused Rat Heart. Analysis of Experimental Data by Reaction:Diffusion Mathema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524e459e3c4c2348785eb65d3c7de094
https://pubmed.ncbi.nlm.nih.gov/10966833