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pro vyhledávání: '"Mayer, Andreas P."'
Autor:
Nagano, Yuta, Pyo, Andrew, Milighetti, Martina, Henderson, James, Shawe-Taylor, John, Chain, Benny, Tiffeau-Mayer, Andreas
Computational prediction of the interaction of T cell receptors (TCRs) and their ligands is a grand challenge in immunology. Despite advances in high-throughput assays, specificity-labelled TCR data remains sparse. In other domains, the pre-training
Externí odkaz:
http://arxiv.org/abs/2406.06397
A key challenge in molecular biology is to decipher the mapping of protein sequence to function. To perform this mapping requires the identification of sequence features most informative about function. Here, we quantify the amount of information (in
Externí odkaz:
http://arxiv.org/abs/2404.12565
An individual's adaptive immune receptor (AIR) repertoire records immune history due to the exquisite antigen specificity of AIRs. Reading this record requires computational approaches for inferring receptor function from sequence, as the diversity o
Externí odkaz:
http://arxiv.org/abs/2403.09010
Autor:
Tiffeau-Mayer, Andreas
Quantification of measurement uncertainty is crucial for robust scientific inference, yet accurate estimates of this uncertainty remain elusive for ecological measures of diversity. Here, we address this longstanding challenge by deriving a closed-fo
Externí odkaz:
http://arxiv.org/abs/2310.03439
Autor:
Westers, Maximilian, Wich, Tobias, Jannett, Louis, Mladenov, Vladislav, Mainka, Christian, Mayer, Andreas
Single Sign-On (SSO) shifts the crucial authentication process on a website to to the underlying SSO protocols and their correct implementation. To strengthen SSO security, organizations, such as IETF and W3C, maintain advisories to address known thr
Externí odkaz:
http://arxiv.org/abs/2302.01024
Autor:
Mayer, Andreas, Russo, Christopher J., Marcou, Quentin, Bialek, William, Greenbaum, Benjamin D.
Biological and artificial neural networks routinely make reliable distinctions between similar inputs, and the rules for making these distinctions are learned. In some ways, self/nonself discrimination in the immune system is similar, being both reli
Externí odkaz:
http://arxiv.org/abs/2212.12049
Publikováno v:
Current Biology 2022
Some prokaryotes possess CRISPR-Cas systems that provide adaptive immunity to viruses guided by DNA segments called spacers acquired from invading phage. However, the patchy incidence and limited memory breadth of CRISPR-Cas systems suggest that thei
Externí odkaz:
http://arxiv.org/abs/2101.01267
Regulatory T cells (Tregs) play a crucial role in mediating immune response. Yet an algorithmic understanding of the role of Tregs in adaptive immunity remains lacking. Here, we present a biophysically realistic model of Treg mediated self-tolerance
Externí odkaz:
http://arxiv.org/abs/2012.00252
Publikováno v:
eLife 2020 9:e61639
The adaptive immune system responds to pathogens by selecting clones of cells with specific receptors. While clonal selection in response to particular antigens has been studied in detail, it is unknown how a lifetime of exposures to many antigens co
Externí odkaz:
http://arxiv.org/abs/2007.11113
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