Výsledky vyhledávání - "Mayca, Onega"

Preclinical evaluation of [18F]FB-A20FMDV2 as a selective marker for measuring αVβ6 integrin occupancy using positron emission tomography in rodent lung

Autor: Christophe Plisson, Lisa Wells, Christine A. Parker, Mayca Onega, Sara Moz, Nicholas Keat, Christopher Coello, Pauline T. Lukey, Giovanni Vitulli, Joaquim Ramada-Magalhaes, Roger N. Gunn, Frederick J. Wilson, Sharon Ashworth, Robert J. Slack, Sac-Pham Tang, Gaia Rizzo, Jan Passchier

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging

PurposeIntegrin αvβ6belongs to the RGD subset of the integrin family, and its expression levels are a prognostic and theranostic factor in some types of cancer and pulmonary fibrosis. This paper describes the GMP radiolabelling of the synthetic 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0df9d47daff9ba4eabf23c6dbb7f6ff
http://europepmc.org/articles/PMC7075836

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Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study)

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging

PurposeThe RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis through activation of transforming growth factor beta (TGFβ). This study sought to quantify expression of αvβ6 in the lungs of healthy humans and subjects with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8060afdd1c972579592568c203db6077
http://europepmc.org/articles/PMC7075837

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A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of 18F-FB-A20FMDV2 for Imaging the Integrin αvβ6

Autor: R. Thomas Lumbers, Pauline T. Lukey, Jan Passchier, Nadia Garman, Nicholas Keat, Robert J. Slack, Mayca Onega, Azeem Saleem, Keguan Chen, Julia Kenny, William A. Hallett, Christine A. Parker

Publikováno v: Journal of Nuclear Medicine Technology. 46:136-143

The αvβ6 integrin is involved in the pathogenesis of cancer and fibrosis. A radiolabeled 20-amino-acid αvβ6-binding peptide, derived from the foot and mouth virus (NAVPNLRGDLQVLAQKVART [A20FMDV2]), has been developed to image αvβ6 levels precli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9903027bfdcc0fba4034daa56806736e
https://doi.org/10.2967/jnmt.117.203547

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A two-step fluorinase enzyme mediated 18F labelling of an RGD peptide for positron emission tomography

Autor: Sharon Ashworth, Mayca Onega, Jan Passchier, David O'Hagan, Ian N. Fleming, Stephen Thompson

Publikováno v: Chemical Communications. 51:13542-13545

The authors thank EPSRC and the Scottish Imaging Network (SINAPSE) for grants. DO’H thanks the Royal Society for a Wolfson Research Merit Award and ST is grateful to the John and Kathleen Watson Scholarship for financial support. A two-step radiola

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acee9ffc666b4821b7ae00ef4d0802d
https://doi.org/10.1039/c5cc05013h

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Quantification of the Specific Translocator Protein Signal of 18F-PBR111 in Healthy Humans: A Genetic Polymorphism Effect on In Vivo Binding

Autor: Aruloly Kamalakaran, David R. Owen, Idriss Bennacef, Alessandro Colasanti, Paul M. Matthews, Eugenii A. Rabiner, Federico Turkheimer, Roger N. Gunn, Qi Guo, Mayca Onega

Publikováno v: Journal of Nuclear Medicine. 54:1915-1923

PET is used to image active inflammatory processes by targeting the translocator protein (TSPO). In vitro, second-generation TSPO radioligands, such as PBR111, have been shown to bind to human tissue samples with either high affinity (high-affinity b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a49233ee0f15ee1884565ba44b813f
https://doi.org/10.2967/jnumed.113.121020

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Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus

Autor: Mayca Onega, Li Chen, Yudong Zhao, Xiaoling Wang, Hai Deng, Sheng Huang, Zhiwei Qin, Jing He, Yi Yu

Publikováno v: Process Biochemistry. 46:811-816

Holomycin is a dithiolopyrrolone antibiotic natural product produced by Streptomyces clavuligerus , ATCC 27064. This paper reports on the identification of a gene cluster from S. clavuligerus that directs holomycin biosynthesis. Heterologous expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a43b43dc5b6b47e1c513c07b5e8725b
https://doi.org/10.1016/j.procbio.2010.11.024

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Fluorinase: a tool for the synthesis of 18F-labeled sugars and nucleosides for PET

Autor: Mayca Onega, Margit Winkler, David O'Hagan

Publikováno v: Future Medicinal Chemistry. 1:865-873

There is an increasing interest in the preparation of 18F-labeled radiopharmaceuticals with potential applications in PET for medicinal imaging. Appropriate synthetic methods require a quick and efficient route in which to incorporate the 18F into a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ceba314691d2ac228549f59394ce42e
https://doi.org/10.4155/fmc.09.74

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The identification of (3R,4S)-5-fluoro-5-deoxy-d-ribulose-1-phosphate as an intermediate in fluorometabolite biosynthesis in Streptomyces cattleya

Autor: Mayca Onega, David O'Hagan, John T. G. Hamilton, Ryan P. McGlinchey, Hai Deng

Publikováno v: Bioorganic Chemistry. 35:375-385

(3R,4S)-5-Fluoro-5-deoxy-D-ribulose-1-phosphate (5-FDRulP) has been identified as the third fluorinated intermediate on the biosynthetic pathway to fluoroacetate and 4-fluorothreonine in Streptomyces cattleya. 5-FDRulP is generated after formation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744bdcc9ddcde316094871a55ad84682
https://doi.org/10.1016/j.bioorg.2007.04.001

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A localized tolerance in the substrate specificity of the fluorinase enzyme enables 'last-step' 18F fluorination of a RGD peptide under ambient aqueous conditions

Autor: Sharon Ashworth, David O'Hagan, Qingzhi Zhang, James H. Naismith, Jan Passchier, Ian N. Fleming, Mayca Onega, Stephen A. McMahon, Stephen Thompson

Publikováno v: Angewandte Chemie (International ed. in English). 53(34)

The authors thank the ERC, EPSRC and the Scottish Imaging Network (SINAPSE) for grants, and the John and Kathleen Watson Scholarship (S.T.) for financial support. A strategy for last-step 18F fluorination of bioconjugated peptides is reported that ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055d60c76492c2b7222c7f37cc7ed165
https://pubmed.ncbi.nlm.nih.gov/24989327

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