Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Mayank Kumar Sharma"'
Publikováno v:
Mini reviews in medicinal chemistry.
Abstract: Selection of a protein structure is an important step for the success of the drug discovery process using structure-based design. Selection of the right crystal structure is a critical step as multiple crystal structures are available for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a1bbf63ea31ccef5095777217c9293
https://pubmed.ncbi.nlm.nih.gov/35549880
https://pubmed.ncbi.nlm.nih.gov/35549880
Autor:
Mayank Kumar Sharma, Prashant R. Murumkar, Mange Ram Yadav, Sadhana J. Rajput, Atul N. Khadse
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 18:1332-1353
Development of new anticoagulants has been in constant demand throughout the world due to increasing rate of morbidity and mortality caused by thrombotic diseases. Factor Xa (FXa), one of the enzymes and validated target for anticoagulation, regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0fdc2824207da29c3309db84ae9e43
https://doi.org/10.2174/1389557518666180424120726
https://doi.org/10.2174/1389557518666180424120726
Publikováno v:
2019 IEEE 5th International Conference for Convergence in Technology (I2CT).
Wireless Sensor Networks [WSN] is formation of sensor nodes deployed in remote areas. It enables sensing of various parameters through wireless network. Low computation and energy consumption with less storage and strong sensing capability has found.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42778ff4699f87b52846a38878a00c81
https://doi.org/10.1109/i2ct45611.2019.9033954
https://doi.org/10.1109/i2ct45611.2019.9033954
Publikováno v:
Current Topics in Medicinal Chemistry. 16:2863-2883
Nitrogen containing heterocyclic rings with an oxygen atom is considered as one of the best combination in medicinal chemistry due to their diversified biological activities. Isoxazole, a five membered heterocyclic azole ring is found in naturally oc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eef4ddfa1d8d554acbfe7e33d39256e
https://doi.org/10.2174/1568026616666160506145700
https://doi.org/10.2174/1568026616666160506145700
Autor:
Prashant R. Murumkar, H Yamaguchi, Mange Ram Yadav, A C Shinde, P B Miniyar, Mayank Kumar Sharma
Publikováno v:
SAR and QSAR in Environmental Research. 27:265-292
Type 2 diabetes mellitus is described by insulin resistance and high fasting blood glucose. Increased levels of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme result in insulin resistance and metabolic syndrome. Inhibition of 11β-HSD1 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5123a175841647b884f08f4b23e29f6
https://doi.org/10.1080/1062936x.2016.1167774
https://doi.org/10.1080/1062936x.2016.1167774
Publikováno v:
RSC Advances. 6:1466-1483
Cannabinoid 1 (CB1) receptors are a potential target for the treatment of obesity due to their role in food intake regulation and energy balance. Adverse effects associated with rimonabant, a CB1 receptor antagonist, have encouraged researchers to ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a4b23eef5b0236f6ff95314dc94d5cf
https://doi.org/10.1039/c5ra20612j
https://doi.org/10.1039/c5ra20612j
Autor:
Tushar R. Sutariya, Prashant R. Murumkar, Gaurangkumar C. Brahmbhatt, Narsidas J. Parmar, Irene Lagunes, José M. Padrón, Mayank Kumar Sharma, Mange Ram Yadav, Hitesh A. Barad
Publikováno v:
New Journal of Chemistry. 40:4931-4939
A multicomponent reaction has been developed by incorporating quinoline-3-carbaldehyde, 1,3-cyclohexanedione and 2,3-diaminopyridine into some new quinolylpyrido[2,3-b][1,4]benzodiazepinone assemblies under catalyst- and solvent-free conditions at 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d224b095ff4161dc6580f7d2d296b0c4
https://doi.org/10.1039/c5nj03280f
https://doi.org/10.1039/c5nj03280f
Publikováno v:
Molecular Diversity. 19:871-893
Peripherally acting cannabinoid 1 (CB1) receptor antagonists are considered as potential therapeutics for the treatment of obesity with desired efficacy and reduced central nervous system side effects. A dataset of 72 compounds containing the 1,5-dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe63f5e28f843b7cf463c4dd5beb758
https://doi.org/10.1007/s11030-015-9611-5
https://doi.org/10.1007/s11030-015-9611-5
Autor:
Prashant R. Murumkar, Rajani Giridhar, Mahesh A. Barmade, Mayank Kumar Sharma, Mange Ram Yadav
Publikováno v:
Expert Opinion on Therapeutic Patents. 25:1093-1116
Introduction: Obesity is a rapidly expanding worldwide health problem. Various targets are investigated presently for the treatment of obesity, but there remains an unmet need for an effective drug therapy with acceptable efficacy levels and reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeab1769df3ad0b695d6cf864f6e5b74
https://doi.org/10.1517/13543776.2015.1064898
https://doi.org/10.1517/13543776.2015.1064898
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-18 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-18 (2018)
Developing peripherally active cannabinoid 1 (CB1) receptor antagonists is a novel therapeutic approach for the management of obesity. An unusual phenothiazine scaffold containing CB1R antagonizing hit was identified by adopting virtual screening wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1f79b8bac754a36629c7f2c6bce9ad
https://doi.org/10.1038/s41598-018-20078-w
https://doi.org/10.1038/s41598-018-20078-w