Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Maya Umekita"'
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Seasonal influenza virus epidemics result in severe illness, and occasionally influenza pandemics cause significant morbidity and mortality, although vaccines and anti-influenza virus drugs are available. By screening an in-house library, we identifi
Externí odkaz:
https://doaj.org/article/77080f8bf704451c8ed9ad8324da2b19
Autor:
Yuriko Ozeki, Masayuki Igarashi, Matsumi Doe, Aki Tamaru, Naoko Kinoshita, Yoshitoshi Ogura, Tomotada Iwamoto, Ryuichi Sawa, Maya Umekita, Shymaa Enany, Yukiko Nishiuchi, Mayuko Osada-Oka, Tetsuya Hayashi, Mamiko Niki, Yoshitaka Tateishi, Masaki Hatano, Sohkichi Matsumoto
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0141658 (2015)
Tuberculosis (TB) is a serious infectious disease caused by a bacterial pathogen. Mortality from tuberculosis was estimated at 1.5 million deaths worldwide in 2013. Development of new TB drugs is needed to not only to shorten the medication period bu
Externí odkaz:
https://doaj.org/article/b00e87b4b8f8406fae21c248ca1c4c43
Autor:
Yasuko Kohda, Shuichi Sakamoto, Maya Umekita, Tomoyuki Kimura, Yumiko Kubota, Rie Arisaka, Yuko Shibuya, Hideyuki Muramatsu, Ryuichi Sawa, Shingo Dan, Manabu Kawada, Masayuki Igarashi
Publikováno v:
The Journal of Antibiotics. 75:77-85
New three macrocyclic diolides, named bispolides C-E (1-3), were isolated from a fermentation broth of the actinomycete strain MG372-hF19, which produces an indole glycoside and leptomycins as we reported previously. The absolute structures of compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e451ca5effc35bffa212b83a55d689c
https://doi.org/10.1038/s41429-021-00492-5
https://doi.org/10.1038/s41429-021-00492-5
Autor:
Ryuichi Sawa, Chigusa Hayashi, Tomoyuki Kimura, Yasuhiro Takehana, Masayuki Igarashi, Maya Umekita, Hideyuki Muramatsu
Publikováno v:
The Journal of Antibiotics. 74:470-473
In the course of screening for new antimicrobial compounds, a new antibiotic substance named saccharobipyrimicin was isolated from the leaf-litter actinomycete Saccharothrix sp. MM696L-181F4. The structure of saccharobipyrimicin was elucidated by var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c90286628d3116775ad738513e5a466
https://doi.org/10.1038/s41429-021-00418-1
https://doi.org/10.1038/s41429-021-00418-1
Autor:
Maya Umekita, Yoshimasa Ishizaki, Chiaki Kato, Masato Suzuki, Rie Arisaka, Ryuichi Sawa, Masayuki Igarashi, Chigusa Hayashi, Masaki Hatano
Publikováno v:
The Journal of Antibiotics. 74:291-299
A Nonomuraea sp. strain MM565M-173N2 was isolated from deep-sea sediment off the Sanriku coast, and new antibiotics were evaluated against carbapenem-resistant Enterobacteriaceae (CRE), which is a problematic group of bacteria because of their antimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d603aae4c5016f013ca1da8819643880
https://doi.org/10.1038/s41429-020-00402-1
https://doi.org/10.1038/s41429-020-00402-1
Autor:
Ryuichi Sawa, Kiyoko Iijima, Taira Kato, Akio Nomoto, Masayuki Igarashi, Masaki Hatano, Chisato Nosaka, Maya Umekita, Kiyohisa Mizumoto, Naoki Takizawa, Manabu Yamasaki, Tomoyuki Kimura
Publikováno v:
The Journal of Antibiotics. 72:125-133
Influenza virus RNA polymerase has cap-dependent endonuclease activity that produces capped RNA fragments for priming viral mRNA synthesis. This enzymatic activity is essential for viral propagation, but it is not present in any host cellular enzyme,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a51941c2a805cfee0bb90648b4a3254
https://doi.org/10.1038/s41429-018-0134-z
https://doi.org/10.1038/s41429-018-0134-z
Publikováno v:
The Journal of Antibiotics. 71:91-96
Drug-resistant bacteria are still emerging, and screening of new skeletal antibiotics is important. During our continuous screening for antimicrobial agents, we discovered a new antimicrobial, named quadoctomycin, from solid culture of Streptomyces s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17b3ca9a7568621ec3e7c3e489c9c34
https://doi.org/10.1038/ja.2017.140
https://doi.org/10.1038/ja.2017.140
Publikováno v:
The Journal of Antibiotics. 70:611-615
New bioactive substances were identified from several marine actinomycetes strains by LC-HRESI-MS based non-targeted metabolomics. A new siderophore and its derivative, named fradiamines A and B, were isolated from the extract of the deep-sea actinom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c80bac7dee757d93504bff827746c7e
https://doi.org/10.1038/ja.2017.26
https://doi.org/10.1038/ja.2017.26
Autor:
Miho Nagayoshi, Masayuki Igarashi, Ryuichi Sawa, Shun-ichi Wada, Masakatsu Shibasaki, Chigusa Hayashi, Maya Umekita, Manabu Kawada, Yumiko Kubota, Masaki Hatano, Toshifumi Takeuchi
Publikováno v:
Organic letters. 19(16)
New 36-membered polyol macrolides deplelides A and B were isolated from the culture of Streptomyces MM581-NF15 by bioassay-guided fractionation using an ATP depletion assay. The planar structures of these novel compounds were identified by interpreta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3500ca97a44f3d440785141e32aa4d
https://pubmed.ncbi.nlm.nih.gov/28786681
https://pubmed.ncbi.nlm.nih.gov/28786681
Autor:
Masaki Hatano, Maya Umekita, Akio Nomoto, Kiyohisa Mizumoto, Manabu Yamasaki, Masayuki Igarashi, Ryuichi Sawa, Toshinobu Fujiwara, Chigusa Hayashi
Publikováno v:
The Journal of antibiotics. 70(5)
Yeast capping enzymes differ greatly from those of mammalian, both structurally and mechanistically. Yeast-type capping enzyme repressors are therefore candidate antifungal drugs. The 5′-guanine-N7 cap structure of mRNAs are an essential feature of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080f1ad213af6ca4620d92b82bd44ab6
https://pubmed.ncbi.nlm.nih.gov/28074052
https://pubmed.ncbi.nlm.nih.gov/28074052