Výsledky vyhledávání - "Maya K. Desai"

CCR5 Knockout Prevents Neuronal Injury and Behavioral Impairment Induced in a Transgenic Mouse Model by a CXCR4-Using HIV-1 Glycoprotein 120

Autor: Marcus Kaul, Rossella Russo, Cyrus M. de Rozieres, Natalia E. Sejbuk, Maya K. Desai, Cari C. Dowling, Melanie M. Hoefer, Gwenn A. Garden, Ana B. Sanchez, Roy Williams, Ricky Maung, Amanda J. Roberts, Kathryn E. Medders, Irene C. Catalan

Publikováno v: The Journal of Immunology. 193:1895-1910

The innate immune system has been implicated in several neurodegenerative diseases, including HIV-1–associated dementia. In this study, we show that genetic ablation of CCR5 prevents microglial activation and neuronal damage in a transgenic model o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74d087d5466c2ec2a4484eb26a314b74
https://doi.org/10.4049/jimmunol.1302915

Zobrazit plný text záznamu

Activation of p38 MAPK Is Required in Monocytic and Neuronal Cells for HIV Glycoprotein 120-Induced Neurotoxicity

Autor: Ricky Maung, Marcus Kaul, Maya K. Desai, Natalia E. Sejbuk, Kathryn E. Medders

Publikováno v: The Journal of Immunology. 185:4883-4895

HIV-1 envelope protein gp120 has been implicated in neurotoxin production by monocytic cells (i.e., macrophages and microglia), as well as in the pathogenesis of HIV-1–associated neurocognitive disorders. We previously showed in cerebrocortical cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3728675d668289d09899134a49dececc
https://doi.org/10.4049/jimmunol.0902535

Zobrazit plný text záznamu

Genetic knockouts suggest a critical role for HIV co-receptors in models of HIV gp120-induced brain injury

Autor: Marcus Kaul, Natalia E. Sejbuk, Rossella Russo, Kathryn E. Medders, Maya K. Desai, Ricky Maung

Publikováno v: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 7(2)

Infection with HIV-1 frequently affects the brain and causes NeuroAIDS prior to the development of overt AIDS. The HIV-1 envelope protein gp120 interacts with host CD4 and chemokine co-receptors to initiate infection of macrophages and lymphocytes. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfbcd8b4a057661749507a0bb782bd99
https://pubmed.ncbi.nlm.nih.gov/22124968

Zobrazit plný text záznamu

An Alzheimer’s Disease-relevant Presenilin-1 Mutation Augments Amyloid-beta-induced Oligodendrocyte Dysfunction

Autor: Maya K. Desai, Brendan J. Guercio, Wade C. Narrow, William J. Bowers

White matter pathology has been documented in the brains of familial Alzheimer's disease (FAD)-afflicted individuals during presymptomatic and preclinical stages of AD. How these defects in myelination integrity arise and what roles they may play in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81916d922521e4d64fd61852fbc87a1
https://europepmc.org/articles/PMC3045399/

Zobrazit plný text záznamu

Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target

Autor: Maya K. Desai, Deborah A. Ryan, Wade C. Narrow, William J. Bowers, Michael A. Mastrangelo, Kelly L. Sudol

Publikováno v: The American journal of pathology. 177(3)

The detection of myelin disruptions in Alzheimer's disease (AD)-affected brain raises the possibility that oligodendrocytes undergo pathophysiological assault over the protracted course of this neurodegenerative disease. Oligodendrocyte compromise ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572bb485dfdcbeca929fec148c7aa470
https://pubmed.ncbi.nlm.nih.gov/20696774

Zobrazit plný text záznamu

P2‐242: Oligodendrocyte cell lineage represents an amyloid beta 1‐42 sensitive cell population leading to white matter alterations during early Alzheimer's disease

Autor: Deborah A. Ryan, Michael A. Mastrangelo, Wade C. Narrow, Maya K. Desai, Kelly L. Sudol, William J. Bowers

Publikováno v: Alzheimer's & Dementia. 6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e109190a2f64640edd49ce6603ad0df7
https://doi.org/10.1016/j.jalz.2010.05.1291

Zobrazit plný text záznamu

Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology

Autor: Maria E. Frazer, Kelly L. Sudol, Maya K. Desai, William J. Bowers, Michelle C. Janelsins, Michael A. Mastrangelo

Publikováno v: Glia. 57(1)

Alzheimer's disease (AD) is a progressively debilitating brain disorder pathologically defined by extracellular amyloid plaques, intraneuronal neurofibrillary tangles, and synaptic disintegrity. AD has not been widely considered a disease of white ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01ac6f3a8bdecb81134352133fd204d
https://pubmed.ncbi.nlm.nih.gov/18661556

Zobrazit plný text záznamu

P3‐404: Triple‐transgenic Alzheimer's disease mice exhibit marked abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology

Autor: Maya K. Desai, William J. Bowers, Kelly L. Sudol, Michael A. Mastrangelo, Maria E. Frazer, Michelle C. Janelsins

Publikováno v: Alzheimer's & Dementia. 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1781b3581ef48d8c5884bab85a2bb74
https://doi.org/10.1016/j.jalz.2008.05.1975

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání