Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Maya Jeitany"'
Autor:
Frances Karla Kusuma, Aishvaryaa Prabhu, Galen Tieo, Syed Moiz Ahmed, Pushkar Dakle, Wai Khang Yong, Elina Pathak, Vikas Madan, Yan Yi Jiang, Wai Leong Tam, Dennis Kappei, Peter Dröge, H. Phillip Koeffler, Maya Jeitany
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
The kinase inhibitor Ponatinib inhibits an ABL1-JUN signalling axis and alters telomere homeostasis, reduces telomere synthesis, and provokes telomere dysfunction in cancer cells which employ the alternative lengthening of telomeres mechanisms.
Externí odkaz:
https://doaj.org/article/bc2741f3057b451aadd3c9a301ac079d
Autor:
Vikas Madan, Zeya Cao, Weoi Woon Teoh, Pushkar Dakle, Lin Han, Pavithra Shyamsunder, Maya Jeitany, Siqin Zhou, Jia Li, Hazimah Binte Mohd Nordin, Jizhong Shi, Shuizhou Yu, Henry Yang, Md Zakir Hossain, Wee Joo Chng, H. Phillip Koeffler
Publikováno v:
Haematologica, Vol 107, Iss 3 (2021)
Recurrent loss-of-function mutations of spliceosome gene, ZRSR2, occur in myelodysplastic syndromes (MDS). Mutation/loss of ZRSR2 in human myeloid cells primarily causes impaired splicing of the U12-type introns. In order to further investigate the r
Externí odkaz:
https://doaj.org/article/02bd4b933f524ce4a9c8cd2646323bfc
Autor:
Yuan Jiang, Yan-Yi Jiang, Jian-Jun Xie, Anand Mayakonda, Masaharu Hazawa, Li Chen, Jin-Fen Xiao, Chun-Quan Li, Mo-Li Huang, Ling-Wen Ding, Qiao-Yang Sun, Liang Xu, Deepika Kanojia, Maya Jeitany, Jian-Wen Deng, Lian-Di Liao, Harmik J. Soukiasian, Benjamin P. Berman, Jia-Jie Hao, Li-Yan Xu, En-Min Li, Ming-Rong Wang, Xin-Gang Bi, De-Chen Lin, H. Phillip Koeffler
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Master regulator transcription factors TP63 and SOX2 have been reported to overlap in genomic occupancy in squamous cell carcinomas (SCCs). Here, the authors demonstrate that TP63 and SOX2 promote co-operatively long non-coding RNA CCAT1 expression t
Externí odkaz:
https://doaj.org/article/f927ec3e43a241b38907cdd1a8dba8c5
Autor:
Maya Jeitany, Cédric Leroy, Priscillia Tosti, Marie Lafitte, Jordy Le Guet, Valérie Simon, Debora Bonenfant, Bruno Robert, Fanny Grillet, Caroline Mollevi, Safia El Messaoudi, Amaëlle Otandault, Lucile Canterel‐Thouennon, Muriel Busson, Alain R Thierry, Pierre Martineau, Julie Pannequin, Serge Roche, Audrey Sirvent
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 4, Pp n/a-n/a (2018)
Abstract The clinical management of metastatic colorectal cancer (mCRC) faces major challenges. Here, we show that nilotinib, a clinically approved drug for chronic myeloid leukaemia, strongly inhibits human CRC cell invasion in vitro and reduces the
Externí odkaz:
https://doaj.org/article/c79f020dc047450c9db38f20c405e854
Autor:
Wai Khang Yong, Grishma Rane, Nurkaiyisah Zaal Anuar, Xiaoman Shao, Chai Yeen Goh, Vartika Khanchandani, Vivian L. S. Kuan, Maya Jeitany, H. Phillip Koeffler, Lih-Wen Deng, Takaomi Sanda, Dennis Kappei
Chromatin immunoprecipitation (ChIP) has been a cornerstone for epigenetic analyses over the last decades, but even coupled to sequencing approaches (ChIP-seq), it is ultimately limited to one protein at a time. In a complementary effort, we here com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::852eb33adff5cf9a1b2fff6a825ec3ba
https://doi.org/10.1101/2023.01.27.525999
https://doi.org/10.1101/2023.01.27.525999
Autor:
Pavithra Shyamsunder, Zeya Cao, H. Phillip Koeffler, Hazimah Binte Mohd Nordin, Zakir Hossain, Wee Joo Chng, Henry Yang, Maya Jeitany, Jizhong Shi, Jia Li, Weoi Woon Teoh, Lin Han, Vikas Madan, Shuizhou Yu, Pushkar Dakle, Siqin Zhou
Recurrent loss-of-function mutations of spliceosome gene, ZRSR2, occur in myelodysplastic syndromes (MDS). Mutation/loss of ZRSR2 in human myeloid cells primarily causes impaired splicing of the U12-type introns. In order to further investigate the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc728bf4c1c0ad97f2a69f8d1117aa2a
https://hdl.handle.net/10356/162693
https://hdl.handle.net/10356/162693
Autor:
Dennis Kappei, Aishvaryaa Prabhu, Vineeth T. Mukundan, Vikas Madan, Pushkar Dakle, Maya Jeitany, Yan-Yi Jiang, Elina Pathak, H. Phillip Koeffler, Deepika Kanojia, Yosef Landesman, Wai Leong Tam
Publikováno v:
Cellular and molecular life sciences : CMLS, vol 78, iss 4
Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences
Proteasome inhibitors, such as bortezomib and carfilzomib, have shown efficacy in anti-cancer therapy in hematological diseases but not in solid cancers. Here, we found that liposarcomas (LPS) are susceptible to proteasome inhibition, and identified
Autor:
Dalal Bakhos-Douaihy, Denis Biard, François D. Boussin, Laurent Gauthier, Chantal Desmaze, Hervé Chneiweiss, Maya Jeitany, Marie-Pierre Junier
Publikováno v:
Oncotarget
Oncogene
Oncogene, 2019, 10 (7), pp.773-784. ⟨10.18632/oncotarget.26616⟩
Oncogene
Oncogene, 2019, 10 (7), pp.773-784. ⟨10.18632/oncotarget.26616⟩
International audience; Some cancer cells elongate their telomeres through the ALT (alternative lengthening of telomeres) pathway, which is based on homologous recombination for the addition of telomere repeats without telomerase activity. General co
Autor:
Xin-Yuan Guan, De-Chen Lin, Yuan Jiang, Lin Han, Jian-Jun Xie, Anand Mayakonda, Chunquan Li, Luay Aswad, Deepika Kanojia, Ruby Yu-Tong Lin, Liang Xu, Yanyu Li, Harvinder Kaur, Pushkar Dakle, Yan-Yi Jiang, H. Phillip Koeffler, Masaharu Hazawa, Maya Jeitany, Melissa J. Fullwood, Jian-Wen Deng, Ying Zhang
SUMMARYTranscriptional network is controlled by master transcription factors (TFs) andcis-regulatory elements through interacting with target sequences and recruiting epigenetic regulators. By integration of enhancer profiling and chromatin accessibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b171c456f1033120f938c80a108617ac
Autor:
De-Chen Lin, Maya Jeitany, Melissa J. Fullwood, Ngan B. Doan, Wei Yang, Jian-Wen Deng, Ruby Yu-Tong Lin, Yueyuan Zheng, Jian-Jun Xie, Yiwu Yan, Chunquan Li, Jonathan W. Said, Xin Yuan Guan, Luay Aswad, Deepika Kanojia, Masaharu Hazawa, Yuan Jiang, Lin Han, Anand Mayakonda, Harvinder Kaur, Yanyu Li, H. Phillip Koeffler, Ying Zhang, Yan-Yi Jiang, Liang Xu, Pushkar Dakle
Publikováno v:
Gastroenterology. 159(4)
Background & Aims We investigated the transcriptome of esophageal squamous cell carcinoma (ESCC) cells, activity of gene regulatory (enhancer and promoter regions), and the effects of blocking epigenetic regulatory proteins. Methods We performed chro