Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Maya Georgieva"'
Autor:
Emilio Mateev, Muhammed Tilahun Muhammed, Ali Irfan, Shubham Sharma, Maya Georgieva, Alexander Zlatkov
Publikováno v:
Pharmacia, Vol 71, Iss , Pp 1-8 (2024)
The pathogenesis of many diseases, such as obesity, depression, cancer, cataract, and neurodegenerative diseases, is related to the generation of reactive oxygen species (ROS). Structures possessing radical-scavenging properties act as antioxidants a
Externí odkaz:
https://doaj.org/article/204dfeffa5e040788cc228057ca9d755
Publikováno v:
Pharmacia, Vol 71, Iss , Pp 1-6 (2024)
Cytochrome P450 is a heme-containing superfamily accountable for the oxidation of various pharmacologically active drugs. The aim of this study was to conduct in silico and in vitro activity assessments of recently synthesized pyrrole-based compounds
Externí odkaz:
https://doaj.org/article/266566de168846f69b24662b0383e027
Publikováno v:
Pharmacia, Vol 71, Iss , Pp 1-10 (2024)
The detection of pyrrole rings in numerous organic compounds with various pharmacological activities, emphasizes its huge importance in medicinal chemistry. Thus, the synthesis of pyrroles continues to arouse interest and Paal-Knorr condensation is c
Externí odkaz:
https://doaj.org/article/1d79dcf1c5ee4607a7014d9d75a9a6c3
Autor:
Emilio Mateev, Ali Irfan, Alexandrina Mateeva, Magdalena Kondeva-Burdina, Maya Georgieva, Alexander Zlatkov
Publikováno v:
Pharmacia, Vol 71, Iss , Pp 1-7 (2024)
Virtual screening is emerging as a highly applied technique and gained prominence as widely used method for the search and identification of potential hits, significantly reducing the time needed to discover novel and effective compounds compared to
Externí odkaz:
https://doaj.org/article/284f397e290449b8b63f3a3f2d7f8a7c
Autor:
Maya Georgieva, Emilio Mateev, Iva Valkova, Hristina Kuteva, Diana Tzankova, Denitsa Stefanova, Yordan Yordanov, Karolina Lybomirova, Alexander Zlatkov, Virginia Tzankova, Magdalena Kondeva-Burdina
Publikováno v:
Molecules, Vol 29, Iss 18, p 4338 (2024)
Neurodegenerative diseases such as Parkinson’s and Alzheimer’s continue to be some of the most significant challenges in modern medicine. Recent research related to the molecular mechanisms of parkinsonism has opened up new approaches to antipark
Externí odkaz:
https://doaj.org/article/318f754feb064a5385231eb3e75ce698
Autor:
Emilio Mateev, Valentin Karatchobanov, Marjano Dedja, Konstantinos Diamantakos, Alexandrina Mateeva, Muhammed Tilahun Muhammed, Ali Irfan, Magdalena Kondeva-Burdina, Iva Valkova, Maya Georgieva, Alexander Zlatkov
Publikováno v:
Pharmaceuticals, Vol 17, Iss 9, p 1171 (2024)
Considering the complex pathogenesis of Alzheimer’s disease (AD), the multi-target ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target strategy. Thus, one novel
Externí odkaz:
https://doaj.org/article/254e25145e6942fa83bc14da3ba7b66f
Publikováno v:
Pharmacia, Vol 70, Iss 4, Pp 1015-1018 (2023)
In the current study, RP-HPLC method for evaluation of 2 pyrrol-based hydrazones in isolated rat synaptosomes was optimized and validated according to ICH guidelines. The synaptosomes were obtained by multiple centrifugations with Percoll reagent and
Externí odkaz:
https://doaj.org/article/6051e0b160914834958475c594e656df
Autor:
Emilio Mateev, Maya Georgieva
Publikováno v:
Pharmacia, Vol 70, Iss 4, Pp 1019-1026 (2023)
Considering the complex pathophysiology of Alzheimer’s disease (AD), the multitarget ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target strategy. Thus, six pyr
Externí odkaz:
https://doaj.org/article/8875603e5b3a44e390aa9cb96c12427a
Publikováno v:
Journal of Central European Agriculture, Vol 24, Iss 3, Pp 652-666 (2023)
This study characterized six introgression lines obtained from crossing two winter bread wheat varieties Albena and Slaveya with the D-genome synthetic hexaploid wheat 530-1. Phenotypically, the lines differed from the parents, as five of them expres
Externí odkaz:
https://doaj.org/article/396d295cc1614b8c90e8418d9cae8ac7
Autor:
Vania Maslarska, Lily Peikova, Maya Georgieva, Stefka Ivanova, Miglena Smerikarova, Stefan Balkanski, Stanislav Bozhanov
Publikováno v:
Pharmacia, Vol 70, Iss 3, Pp 681-688 (2023)
Background: The contemporary treatment of ulcerogenic diseases and gastroesophageal reflux disease is related usually to application of a combination of imidazole-based antibacterial, antibiotic and proton pump inhibitor. In the current study, the th
Externí odkaz:
https://doaj.org/article/4a37d2ef7b2b45408bdea98692d83451