The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

Autor: Robert C, Jones, Jim, Karkanias, Mark A, Krasnow, Angela Oliveira, Pisco, Stephen R, Quake, Julia, Salzman, Nir, Yosef, Bryan, Bulthaup, Phillip, Brown, William, Harper, Marisa, Hemenez, Ravikumar, Ponnusamy, Ahmad, Salehi, Bhavani A, Sanagavarapu, Eileen, Spallino, Ksenia A, Aaron, Waldo, Concepcion, James M, Gardner, Burnett, Kelly, Nikole, Neidlinger, Zifa, Wang, Sheela, Crasta, Saroja, Kolluru, Maurizio, Morri, Serena Y, Tan, Kyle J, Travaglini, Chenling, Xu, Marcela, Alcántara-Hernández, Nicole, Almanzar, Jane, Antony, Benjamin, Beyersdorf, Deviana, Burhan, Kruti, Calcuttawala, Matthew M, Carter, Charles K F, Chan, Charles A, Chang, Stephen, Chang, Alex, Colville, Rebecca N, Culver, Ivana, Cvijović, Gaetano, D'Amato, Camille, Ezran, Francisco X, Galdos, Astrid, Gillich, William R, Goodyer, Yan, Hang, Alyssa, Hayashi, Sahar, Houshdaran, Xianxi, Huang, Juan C, Irwin, SoRi, Jang, Julia Vallve, Juanico, Aaron M, Kershner, Soochi, Kim, Bernhard, Kiss, William, Kong, Maya E, Kumar, Angera H, Kuo, Rebecca, Leylek, Baoxiang, Li, Gabriel B, Loeb, Wan-Jin, Lu, Sruthi, Mantri, Maxim, Markovic, Patrick L, McAlpine, Antoine, de Morree, Karim, Mrouj, Shravani, Mukherjee, Tyler, Muser, Patrick, Neuhöfer, Thi D, Nguyen, Kimberly, Perez, Ragini, Phansalkar, Nazan, Puluca, Zhen, Qi, Poorvi, Rao, Hayley, Raquer-McKay, Nicholas, Schaum, Bronwyn, Scott, Bobak, Seddighzadeh, Joe, Segal, Sushmita, Sen, Shaheen, Sikandar, Sean P, Spencer, Lea C, Steffes, Varun R, Subramaniam, Aditi, Swarup, Michael, Swift, Will, Van Treuren, Emily, Trimm, Stefan, Veizades, Sivakamasundari, Vijayakumar, Kim Chi, Vo, Sevahn K, Vorperian, Wanxin, Wang, Hannah N W, Weinstein, Juliane, Winkler, Timothy T H, Wu, Jamie, Xie, Andrea R, Yung, Yue, Zhang, Angela M, Detweiler, Honey, Mekonen, Norma F, Neff, Rene V, Sit, Michelle, Tan, Jia, Yan, Gregory R, Bean, Vivek, Charu, Erna, Forgó, Brock A, Martin, Michael G, Ozawa, Oscar, Silva, Angus, Toland, Venkata N P, Vemuri, Shaked, Afik, Kyle, Awayan, Olga Borisovna, Botvinnik, Ashley, Byrne, Michelle, Chen, Roozbeh, Dehghannasiri, Adam, Gayoso, Alejandro A, Granados, Qiqing, Li, Gita, Mahmoudabadi, Aaron, McGeever, Julia Eve, Olivieri, Madeline, Park, Neha, Ravikumar, Geoff, Stanley, Weilun, Tan, Alexander J, Tarashansky, Rohan, Vanheusden, Peter, Wang, Sheng, Wang, Galen, Xing, Rebecca, Culver, Les, Dethlefsen, Po-Yi, Ho, Shixuan, Liu, Jonathan S, Maltzman, Ross J, Metzger, Koki, Sasagawa, Rahul, Sinha, Hanbing, Song, Bruce, Wang, Steven E, Artandi, Philip A, Beachy, Michael F, Clarke, Linda C, Giudice, Franklin W, Huang, Kerwyn Casey, Huang, Juliana, Idoyaga, Seung K, Kim, Mark, Krasnow, Christin S, Kuo, Patricia, Nguyen, Thomas A, Rando, Kristy, Red-Horse, Jeremy, Reiter, David A, Relman, Justin L, Sonnenburg, Albert, Wu, Sean M, Wu, Tony, Wyss-Coray

Publikováno v: Science
Tabula Sapiens Consortium* 2022, ' The Tabula Sapiens : A multiple-organ, single-cell transcriptomic atlas of humans ', Science (New York, N.Y.), vol. 376, no. 6594, pp. eabl4896 . https://doi.org/10.1126/science.abl4896

INTRODUCTION: Although the genome is often called the blueprint of an organism, it is perhaps more accurate to describe it as a parts list composed of the various genes that may or may not be used in the different cell types of a multicellular organi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f726fc016f86cd4ce8c15a69dce9f6be
https://pubmed.ncbi.nlm.nih.gov/36198687

Shunt-type plexiform lesions identified in the Sugen5416/hypoxia rat model of pulmonary arterial hypertension using synchrotron-based phase-contrast micro-CT

Autor: Oscar van der Have, Christian Westöö, Filip Ahrné, Xuefei Tian, Kenzo Ichimura, Till Dreier, Christian Norvik, Maya E. Kumar, Edda Spiekerkoetter, Karin Tran-Lundmark

Publikováno v: European Respiratory Journal. 59:2102802

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909e8d1c031dbc54bc27449cbc713472
https://doi.org/10.1183/13993003.02802-2021

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

Autor: Nicholas Schaum, Ashley Maynard, Kenneth I. Weinberg, Ishita Bansal, Annie Lo, Christin S. Kuo, Hamid Ebadi, Norma Neff, Bryan D. Merrill, Gunsagar S. Gulati, Michelle B. Chen, Nathalie Khoury, Song E. Lee, Martin J. Zhang, Michael N. Wosczyna, Linda J. van Weele, Lakshmi P. Yerra, James Zou, Matt Fish, Michael F. Clarke, Antoine de Morrée, Lucas M. Waldburger, Kyle J. Travaglini, Maria F. Lugo-Fagundo, Yan Hang, Rasika Patkar, Kerwyn Casey Huang, Weng Chuan Peng, Wan Jin Lu, Astrid Gillich, Andrew May, Aaron Demers, Tony Wyss-Coray, Benoit Lehallier, William Kong, Douglas Brownfield, Robert C. Jones, Katharine M. Ng, Ankit S. Baghel, Patricia K. Nguyen, Rafael Gòmez-Sjöberg, Katherine S. Pollard, Ling Liu, Kevin S. Kao, Róbert Pálovics, Taichi Isobe, Chunyu Zhao, Roel Nusse, Eric J. Rulifson, Maya E. Kumar, Bruce Wang, Philip A. Beachy, Tessa Divita, Ross J. Metzger, Cristina M. Tato, Thomas A. Rando, Marina McKay, Hui Zhang, Oliver Hahn, Jinyi Xiang, Jane Antony, Aaron McGeever, Daniel Staehli, Macy E. Zardeneta, Tal Iram, Olivia Leventhal, Qingyun Li, Angela Oliveira Pisco, Lolita Penland, Krissie Tellez, Marco Mignardi, Brian Yu, Shaheen S. Sikandar, Lincoln Harris, Nicole Almanzar, Corey Cain, Geraldine Genetiano, Foad Green, Davis P. Lee, Carolina Tropini, Laughing Bear Torrez Dulgeroff, Rahul Sinha, Zhen Qi, Stephen R. Quake, Charles Chan, Irving L. Weissman, Sean M. Wu, Jim Karkanias, Ahmad N. Nabhan, Andreas Keller, Margaret Tsui, Alexander Zee, Guruswamy Karnam, Michael S. Haney, Haley du Bois, Robert Puccinelli, Ben A. Barres, Justin L. Sonnenburg, F. Hernan Espinoza, Fabio Zanini, Qiang Gan, Joseph Noh, Lu Zhou, Isaac Bakerman, Aaron M. Kershner, Mark A. Krasnow, Kubilay Demir, Feather Ives, Benson M. George, Guang Li, Dullei Min, Justin Youngyunpipatkul, Mu He, Rene V. Sit, Bernhard M. Kiss, Stephanie D. Conley, Seung K. Kim, Weilun Tan, Soso Xue, M. Windy McNerney, Andrew C. Yang, Kevin A. Yamauchi, Albin Huang, Joe M. Segal, Krzysztof Szade, Michelle Tan, Biter Bilen, Fan Zhang, Spyros Darmanis, Shayan Hosseinzadeh, Xueying Gu, Jonathan K. Lam, Anoop Manjunath, Daniela Berdnik

Publikováno v: Nature

Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death(1). Despite rapid advances over recent years, many of the molecular and cellular processes which underlie progr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c3489ceeac8cf1e8dc138771ff6428
https://ruj.uj.edu.pl/xmlui/handle/item/279563

Defining a mesenchymal progenitor niche at single cell resolution

Autor: David M. Kingsley, Maya E. Kumar, Mark A. Krasnow, F. Hernan Espinoza, Douglas B. Menke, Patrick E. Bogard

Most vertebrate organs are composed of epithelium surrounded by support and stromal tissues formed from mesenchyme cells, which are not generally thought to form organized progenitor pools. Here, we use clonal cell labeling with multicolor reporters

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cdcd6e8e5dce39803b5c16359f7536d
https://europepmc.org/articles/PMC4269943/

Radial Construction of an Arterial Wall

Autor: Ling Ding, Mark A. Krasnow, Stefan Offermanns, Maya E. Kumar, Andrew An, Janet K. Lighthouse, Kristy Red-Horse, Justine Hum, Daniel Greif, Lorin E. Olson, F. Hernan Espinoza

Publikováno v: Developmental Cell. (3):482-493

SummarySome of the most serious diseases involve altered size and structure of the arterial wall. Elucidating how arterial walls are built could aid understanding of these diseases, but little is known about how concentric layers of muscle cells and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09059b7a31fe9d4e57304b8a7c08bba0