Výsledky vyhledávání - "Maya Deshmukh"

Akademický článek

Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents.

Autor: Sergei Perov, Ofir Lidor, Nir Salinas, Nimrod Golan, Einav Tayeb-Fligelman, Maya Deshmukh, Dieter Willbold, Meytal Landau

Publikováno v: PLoS Pathogens, Vol 15, Iss 8, p e1007978 (2019)

Curli amyloid fibrils secreted by Enterobacteriaceae mediate host cell adhesion and contribute to biofilm formation, thereby promoting bacterial resistance to environmental stressors. Here, we present crystal structures of amyloid-forming segments fr

Externí odkaz: https://doaj.org/article/83c99c52c5774ca1866971d3d107d047

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Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations

Autor: Zhuobin Liang, Shalley N. Kudalkar, Krasimir A. Spasov, Julian Tirado-Rives, Scott J. Miller, Shuo Zhang, Karen S. Anderson, Maya Deshmukh, Brett D. Lindenbach, William L. Jorgensen, Joseph A. Ippolito, Farren J. Isaacs, Elizabeth A Stone, Mohammad Mehdi Ghahremanpour, Yuka Takeo, Chun-Hui Zhang

Publikováno v: ACS Central Science
ACS Central Science, Vol 7, Iss 3, Pp 467-475 (2021)

Starting from our previous finding of 14 known drugs as inhibitors of the main protease (Mpro) of SARS-CoV-2, the virus responsible for COVID-19, we have redesigned the weak hit perampanel to yield multiple noncovalent, nonpeptidic inhibitors with ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db12c0c2f741e3fc9cfbd59aafa02302
https://doi.org/10.1021/acscentsci.1c00039

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THE RISK OF DEMENTIA AMONG INDIVIDUALS WITH DEPRESSION AFTER A TRAUMATIC BRAIN INJURY

Autor: Joan Ashby, Miriam Nuno, Beatrice Ugiliweneza, Maya Deshmukh, Maxwell Boakye

Publikováno v: Innovation in Aging. 6:466-466

Although traumatic brain injury (TBI) has been found to be associated with dementia and depression, large-scale studies of US non-Veteran populations are limited. This study assesses the role of depression on dementia risk after TBI. Data was analyze

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9404c608c79f726b862ef18a7b20aa3c
https://doi.org/10.1093/geroni/igac059.1811

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Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency

Autor: Maria-Elena Liosi, Krasimir A. Spasov, Zhuobin Liang, Chun-Hui Zhang, Karen S. Anderson, Scott J. Miller, Joseph A. Ippolito, Brett D. Lindenbach, Klarissa Hollander, Julian Tirado-Rives, Maya Deshmukh, Raquel A. Reilly, Farren J. Isaacs, William L. Jorgensen, Shuo Zhang, Elizabeth A Stone

Publikováno v: ACS Medicinal Chemistry Letters

Non-covalent inhibitors of the main protease (Mpro) of SARS-CoV-2 having a pyridinone core were previously reported with IC50 values as low as 0.018 μM for inhibition of enzymatic activity and EC50 values as low as 0.8 μM for inhibition of viral re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b293575cd562301efcbe9393fcf6b02
https://pubmed.ncbi.nlm.nih.gov/34408808

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Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease

Autor: Joseph A. Ippolito, Maya Deshmukh, Chun-Hui Zhang, Raquel A. Reilly, William L. Jorgensen, Karen S. Anderson, Scott J. Miller, Elizabeth A Stone

Publikováno v: Structure (London, England : 1993)

There is a clinical need for direct-acting antivirals targeting SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, to complement current therapeutic strategies. The main protease (Mpro) is an attractive target for antiviral therapy. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51cbd3573f9443ea650cb675f88027b
https://pubmed.ncbi.nlm.nih.gov/34161756

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Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2

Autor: Israel Cabeza de Vaca, Chun-Hui Zhang, Karen S. Anderson, Julian Tirado-Rives, Maria-Elena Liosi, Mohammad Mehdi Ghahremanpour, Joseph A. Ippolito, Maya Deshmukh, William L. Jorgensen

Publikováno v: ACS Medicinal Chemistry Letters
bioRxiv

A consensus virtual screening protocol has been applied to ca. 2000 approved drugs to seek inhibitors of the main protease (Mpro) of SARS-CoV-2, the virus responsible for COVID-19. 42 drugs emerged as top candidates, and after visual analyses of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ddb3660099a840c2701da2439a43f6
https://doi.org/10.1101/2020.08.28.271957

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Amyloid by Design: Intrinsic Regulation of Microbial Amyloid Assembly

Autor: Maya Deshmukh, Margery L. Evans, Matthew George Chapman

Publikováno v: Journal of Molecular Biology. 430:3631-3641

The term amyloid has historically been used to describe fibrillar aggregates formed as the result of protein misfolding and that are associated with a range of diseases broadly termed amyloidoses. The discovery of "functional amyloids" expanded the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ebb1fd9724f333e636e62f81afa3f8
https://doi.org/10.1016/j.jmb.2018.07.007

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The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation

Autor: Audrey Beaussart, Tim Schulte, Christine Ebel, Birgitta Henriques-Normark, Jonas Lofling, Dmitri I. Svergun, Federico Fogolari, Adnane Achour, Cecilia Mikaelsson, Yves F. Dufrêne, Anuj Pathak, Sebastian Wolniak, Alexey Kikhney, Per-Åke Nygren, Maya Deshmukh

Publikováno v: Scientific Reports, Vol. 6, p. 32371 (2016)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2016, 6, pp.32371. ⟨10.1038/srep32371⟩
Scientific Reports, 2016, 6, pp.32371. ⟨10.1038/srep32371⟩
'Scientific Reports ', vol: 6, pages: 32371-1-32371-11 (2016)

The major human pathogen Streptococcus pneumoniae is a leading cause of disease and death worldwide. Pneumococcal biofilm formation within the nasopharynx leads to long-term colonization and persistence within the host. We have previously demonstrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170af52df54caaa3c818a1adaf3c0ad1
http://hdl.handle.net/11390/1102998

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Hox cluster duplication in the basal teleost Hiodon alosoides (Osteoglossomorpha)

Autor: Peter F. Stadler, Maya Deshmukh, Jeremy Raincrow, Karen E. Chambers, Chi-hua Chiu, Ryan McDaniell

Publikováno v: Theory in Biosciences

Large-scale—even genome-wide—duplications have repeatedly been invoked as an explanation for major radiations. Teleosts, the most species-rich vertebrate clade, underwent a “fish-specific genome duplication” (FSGD) that is shared by most ray-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271fb04920ec7b1f950ed1ec85445dbd

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