Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Maya Boyanova"'
Publikováno v:
Biotechnology & Biotechnological Equipment. 26:170-174
Glycation of recombinant human interferon-gamma (rhIFN-γ) causes conformational alterations of the molecule and results in reduction of its biologic activity. The aim of this study was to find adeq...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa7bc829e370be4abe1f22395746538c
https://doi.org/10.5504/50yrtimb.2011.0031
https://doi.org/10.5504/50yrtimb.2011.0031
Publikováno v:
Biotechnology & Biotechnological Equipment. 24:1904-1909
Glycation is a non-emzymatic reaction between free amino groups and reducing sugars (16), which was shown to take place also in human (13). It causes severe complications in diabetic and uremic patients, whereas in normal subjects contributes to sene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::017b0628540eab44ed318ecc3bd09148
https://doi.org/10.2478/v10133-010-0036-0
https://doi.org/10.2478/v10133-010-0036-0
Publikováno v:
Biotechnology & Biotechnological Equipment. 23:1063-1067
Recombinant human interferon-gamma (rhIFN-γ) produced in Escherichia coli (E. coli) undergoes structural and functional alterations as a result of two different but parallel processes—aggregation and non-enzymatic glycosylation (glycation). Findin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c67c0e6f5c671c670a3f76feb35ec033
https://doi.org/10.1080/13102818.2009.10817613
https://doi.org/10.1080/13102818.2009.10817613
Publikováno v:
Biotechnology & Biotechnological Equipment. 21:177-181
The effect of temperature, mechanical stress and surface tension on fluorescence and biological activity of recombinant human interferon gamma (rhIFN-γ) was studied. All three physical factors caused a similar decrease of fluorescence intensity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40dc604a93713d11506188b324870992
https://doi.org/10.1080/13102818.2007.10817440
https://doi.org/10.1080/13102818.2007.10817440
Publikováno v:
Biotechnology & Biotechnological Equipment. 21:215-219
Equations were derived describing the fluorescence intensity of IFNy solutions on the basis of a dimer-monomers equilibrium of the native protein. The experimental data were found to fit very well the theoretical values predicted by these equations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2bb99d90f68acb98d33ee566b8b3d2a
https://doi.org/10.1080/13102818.2007.10817448
https://doi.org/10.1080/13102818.2007.10817448
Publikováno v:
Analytical Biochemistry. 308:178-181
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a87284f99001cf59efcd9d0ce38f3ed
https://doi.org/10.1016/s0003-2697(02)00208-7
https://doi.org/10.1016/s0003-2697(02)00208-7
Autor:
Stefan Petrov, Ivan Ivanov, Maya Boyanova, Genoveva Nacheva, Alfredo Berzal-Herranz, Andrey Karshikoff
Publikováno v:
Scopus-Elsevier
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Interferon-gamma (IFNγ) accomplishes its multiple biological effects by activating the STAT transcription factors, which are translocated to the nucleus through a specific nuclear localization sequence(s) (NLS) located in the IFNγ molecule. Two put
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff1e370bb36428bcfc74c2fa057f41e
http://hdl.handle.net/10261/143763
http://hdl.handle.net/10261/143763
Publikováno v:
National Institute of Allergy and Infectious Diseases, NIH ISBN: 9781934115770
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d9b4b4354fb1e9d4a9e4e041a9aa41d
https://doi.org/10.1007/978-1-59745-569-5_41
https://doi.org/10.1007/978-1-59745-569-5_41
Publikováno v:
The Journal of biological chemistry. 278(51)
Until recently, nonenzymatic glycosylation (glycation) was thought to affect the proteins of long living eukaryotes only. However, in a recent study (Mironova, R., Niwa, T., Hayashi, H., Dimitrova, R., and Ivanov, I. (2001) Mol. Microbiol. 39, 1061-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b6855aa37c05143c149ca866cf2a2d
https://pubmed.ncbi.nlm.nih.gov/14525998
https://pubmed.ncbi.nlm.nih.gov/14525998
Autor:
Ivan Ivanov, Kristina Todorova, Maya Boyanova, Genoveva Nacheva, Andrey Karshikoff, Alfredo Berzal-Herranz
Publikováno v:
Archives of biochemistry and biophysics. 413(1)
The significance of the C-terminal part of human interferon gamma (hIFNgamma) for its biological activity was studied by 3(')-end gene mutagenesis. A series of nine derivative genes obtained by systemic deletion of three codons was constructed and ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad6cc15c70577f7908223ee4ed58e1e
https://pubmed.ncbi.nlm.nih.gov/12706345
https://pubmed.ncbi.nlm.nih.gov/12706345