Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Maya Aleksandrova"'
Autor:
Tsoklinova, Maya Aleksandrova1 maya.koleva@unwe.bg
Publikováno v:
Dialogue (1311-9206). 2024, Issue 1, p46-59. 14p.
Autor:
Daniel Herranz, Hossein Khiabanian, Xiaoyang Su, Pedro P. Rocha, Zhenyu Zuo, Eric Chiles, Haiyan Zheng, Caifeng Zhao, Shirley Luo, Patricia Renck Nunes, Luca Tottone, Jesminara Khatun, Maya Aleksandrova, Victoria da Silva-Diz, Amartya Singh, Olga Lancho
T-cell acute lymphoblastic leukemia (T-ALL) is a NOTCH1-driven disease in need of novel therapies. Here, we identify a NOTCH1–SIRT1–KAT7 link as a therapeutic vulnerability in T-ALL, in which the histone deacetylase SIRT1 is overexpressed downstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b138f3c30ed860fed6fefc995070081d
https://doi.org/10.1158/2643-3230.c.6551054
https://doi.org/10.1158/2643-3230.c.6551054
Autor:
Daniel Herranz, Hossein Khiabanian, Xiaoyang Su, Pedro P. Rocha, Zhenyu Zuo, Eric Chiles, Haiyan Zheng, Caifeng Zhao, Shirley Luo, Patricia Renck Nunes, Luca Tottone, Jesminara Khatun, Maya Aleksandrova, Victoria da Silva-Diz, Amartya Singh, Olga Lancho
GSEA analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4797daa36a6079f88c8fd29da79b6f9b
https://doi.org/10.1158/2643-3230.22545920.v1
https://doi.org/10.1158/2643-3230.22545920.v1
Autor:
Victoria da Silva-Diz, Amartya Singh, Olga Lancho, Maya Aleksandrova, Komal Mandleywala, Patricia Renck Nunes, Jesminara Khatun, Oekyung Kim, Eric Chiles, Xiaoyang Su, Hossein Khiabanian, Kathryn E. Wellen, Daniel Herranz
Publikováno v:
bioRxiv
T-cell Acute Lymphoblastic Leukemia (T-ALL) is a hematological malignancy in need of novel therapeutic approaches. Here, we identify the ATP-citrate lyase ACLY as a novel therapeutic target in T-ALL. Our results show that ACLY is overexpressed in T-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ed518a84af5d86703d12afe93dddab
https://europepmc.org/articles/PMC10081278/
https://europepmc.org/articles/PMC10081278/
Autor:
Caroline R. Bartman, Daniel R. Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han, Tara TeSlaa, Connor S. R. Jankowski, Laith Samarah, Noel R. Park, Victoria da Silva-Diz, Maya Aleksandrova, Yetis Gultekin, Argit Marishta, Lin Wang, Lifeng Yang, Asael Roichman, Vrushank Bhatt, Taijin Lan, Zhixian Hu, Xi Xing, Wenyun Lu, Shawn Davidson, Martin Wühr, Matthew G. Vander Heiden, Daniel Herranz, Jessie Yanxiang Guo, Yibin Kang, Joshua D. Rabinowitz
Publikováno v:
Nature
Nature, vol 614, iss 7947
Nature, vol 614, iss 7947
Tissues derive ATP from two pathways-glycolysis and the tricarboxylic acid (TCA) cycle coupled to the electrontransport chain. Most energy in mammals is produced via TCA metabolism1. In tumours, however, the absolute rates of these pathways remain un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24537985f0041d48ddf65a08c08ae8e3
https://europepmc.org/articles/PMC10288502/
https://europepmc.org/articles/PMC10288502/
Autor:
Olga Lancho, Amartya Singh, Victoria da Silva-Diz, Maya Aleksandrova, Jesminara Khatun, Luca Tottone, Patricia Renck Nunes, Shirley Luo, Caifeng Zhao, Haiyan Zheng, Eric Chiles, Zhenyu Zuo, Pedro P. Rocha, Xiaoyang Su, Hossein Khiabanian, Daniel Herranz
Publikováno v:
Blood Cancer Discov
T-cell acute lymphoblastic leukemia (T-ALL) is a NOTCH1-driven disease in need of novel therapies. Here, we identify a NOTCH1–SIRT1–KAT7 link as a therapeutic vulnerability in T-ALL, in which the histone deacetylase SIRT1 is overexpressed downstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939b6b85f53481ca8ab1df6a2160907f
https://doi.org/10.1101/2022.05.21.492944
https://doi.org/10.1101/2022.05.21.492944
Publikováno v:
Matrix Biol
Laminin polymerization is a key step of basement membrane assembly that depends on the binding of α, β and γ N-terminal LN domains to form a polymer node. Nodal assembly can be divided into two steps consisting of β- and γ-LN dimerization follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e078a73bf1ffd81ac03ab2421f52fe5
https://europepmc.org/articles/PMC8223250/
https://europepmc.org/articles/PMC8223250/
A mutation affecting laminin alpha 5 polymerisation gives rise to a syndromic developmental disorder
Autor:
Denny L Cottle, John E. Dowling, Amali Mallawaarachchi, Andrew Mallett, Cas Simons, Hugh J. McCarthy, Peter D. Yurchenco, Kieran M. Short, Karen K. McKee, Ian M. Smyth, Rachel Lam, J. Miner, Stephen I. Alexander, Lynn Pais, Lynelle K. Jones, Maya Aleksandrova
Publikováno v:
Development
Laminin alpha 5 (LAMA5) is a member of a large family of proteins which trimerize and then polymerise to form a central component of all basement membranes. Consequently, the protein plays an instrumental role in shaping the normal development of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5463bff8b7ca61541b4b8cc7e20aa420
https://europepmc.org/articles/PMC7540250/
https://europepmc.org/articles/PMC7540250/
Publikováno v:
Matrix biology : journal of the International Society for Matrix Biology
Laminin polymerization is a key step of basement membrane self-assembly that depends on the binding of the three different N-terminal globular LN domains. Several mutations in the LN domains cause LAMA2-deficient muscular dystrophy and LAMB2-deficien
Autor:
Luca Tottone, Xiaoyang Su, Olga Lancho, Maya Aleksandrova, Shirley Luo, Amartya Singh, Daniel Herranz, Victoria da Silva-Diz, Patricia Renck Nunes, Hossein Khiabanian
Publikováno v:
Blood. 138:2221-2221
T-cell Acute Lymphoblastic Leukemia (T-ALL) is an aggressive hematological malignancy that affects both children and adults. Still, 20%-50% of patients show primary resistance or relapse after treatment, and ultimately die from their disease. Aberran