Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Maya A Farha"'
Autor:
Keaton W. Smith, Brian P. Alcock, Shawn French, Maya A. Farha, Amogelang R. Raphenya, Eric D. Brown, Andrew G. McArthur
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Resistance-modifying agents have been historically underrepresented in the Comprehensive Antibiotic Resistance Database (CARD). In the process of curating over 60 new molecules into CARD’s Antibiotic Resistance Ontology, the limitations of
Externí odkaz:
https://doaj.org/article/bab09d136546404591c464ef06b4ba47
Autor:
Kristoffer T. Bæk, Camilla Jensen, Maya A. Farha, Tobias K. Nielsen, Ervin Paknejadi, Viktor H. Mebus, Martin Vestergaard, Eric D. Brown, Dorte Frees
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Staphylococcus aureus is a leading cause of bacterial infections world-wide. Staphylococcal infections are preferentially treated with β-lactam antibiotics, however, methicillin-resistant S. aureus (MRSA) strains have acquired resistance to this sup
Externí odkaz:
https://doaj.org/article/599a7e657878488191ef94e3180e68e1
Autor:
Kristina Klobucar, Emily Jardine, Maya A. Farha, Marc R. MacKinnon, Meghan Fragis, Brenda Nkonge, Timsy Bhando, Louis Borrillo, Caressa N. Tsai, Jarrod W. Johnson, Brian K. Coombes, Jakob Magolan, Eric D. Brown
Publikováno v:
ACS Infectious Diseases. 8:2187-2197
Gram-negative bacteria are intrinsically resistant to a plethora of antibiotics that effectively inhibit the growth of Gram-positive bacteria. The intrinsic resistance of Gram-negative bacteria to classes of antibiotics, including rifamycins, aminoco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f634e3730d232d4470b6318d1f9197
https://doi.org/10.1021/acsinfecdis.2c00357
https://doi.org/10.1021/acsinfecdis.2c00357
Autor:
Jonathan Day, Sara S. El Zahed, Chris Bon, Natalie C. J. Strynadka, Michael G. Organ, Eric D. Brown, Maya A. Farha, Sean D. Workman
Publikováno v:
Journal of Medicinal Chemistry. 64:13540-13550
The polyprenyl lipid undecaprenyl phosphate (C55P) is the universal carrier lipid for the biosynthesis of bacterial cell wall polymers. C55P is synthesized in its pyrophosphate form by undecaprenyl pyrophosphate synthase (UppS), an essential cis-pren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4907d8c30130dc54dbd15bd22a0c6d28
https://doi.org/10.1021/acs.jmedchem.1c00941
https://doi.org/10.1021/acs.jmedchem.1c00941
Autor:
Brian P Alcock, William Huynh, Romeo Chalil, Keaton W Smith, Amogelang R Raphenya, Mateusz A Wlodarski, Arman Edalatmand, Aaron Petkau, Sohaib A Syed, Kara K Tsang, Sheridan J C Baker, Mugdha Dave, Madeline C McCarthy, Karyn M Mukiri, Jalees A Nasir, Bahar Golbon, Hamna Imtiaz, Xingjian Jiang, Komal Kaur, Megan Kwong, Zi Cheng Liang, Keyu C Niu, Prabakar Shan, Jasmine Y J Yang, Kristen L Gray, Gemma R Hoad, Baofeng Jia, Timsy Bhando, Lindsey A Carfrae, Maya A Farha, Shawn French, Rodion Gordzevich, Kenneth Rachwalski, Megan M Tu, Emily Bordeleau, Damion Dooley, Emma Griffiths, Haley L Zubyk, Eric D Brown, Finlay Maguire, Robert G Beiko, William W L Hsiao, Fiona S L Brinkman, Gary Van Domselaar, Andrew G McArthur
Publikováno v:
Nucleic acids research.
The Comprehensive Antibiotic Resistance Database (CARD; card.mcmaster.ca) combines the Antibiotic Resistance Ontology (ARO) with curated AMR gene (ARG) sequences and resistance-conferring mutations to provide an informatics framework for annotation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fc299cd5e8184133784ff0a1dd7dca
https://pubmed.ncbi.nlm.nih.gov/36263822
https://pubmed.ncbi.nlm.nih.gov/36263822
Publikováno v:
Accounts of Chemical Research. 54:1909-1920
ConspectusDrug-resistant bacterial infections pose an imminent and growing threat to public health. The discovery and development of new antibiotics of novel chemical class and mode of action that are unsusceptible to existing resistance mechanisms i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680917dc5ae291edca9c0208d6195dae
https://doi.org/10.1021/acs.accounts.1c00011
https://doi.org/10.1021/acs.accounts.1c00011
Autor:
Andrew G. McArthur, Craig R. MacNair, Hiu-Ki R Tran, Lindsey A. Carfrae, Eric D. Brown, Sara S. El Zahed, Michael J. Ellis, Maya A. Farha
Publikováno v:
ACS Infectious Diseases. 6:2709-2718
The growing challenge of microbial resistance emphasizes the importance of new antibiotics or reviving strategies for the use of old ones. Macrolide antibiotics are potent bacterial protein synthesis inhibitors with a formidable capacity to treat lif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550c467959dcfee020c555beb41a3cc1
https://doi.org/10.1021/acsinfecdis.0c00340
https://doi.org/10.1021/acsinfecdis.0c00340
Autor:
Maya A. Farha, Lindsey A. Carfrae, Nicholas G. Jentsch, Jakob Magolan, Craig R. MacNair, Omar M. El-Halfawy, Eric D. Brown, Robert T. Gale, Xiong Zhang
Publikováno v:
ACS Infectious Diseases. 6:338-346
The spread of antimicrobial resistance continues to be a priority health concern worldwide, necessitating exploration of alternative therapies. Cannabis sativa has long been known to contain antibacterial cannabinoids, but their potential to address
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f973ffea8c2fcd19160c257eaee23210
https://doi.org/10.1021/acsinfecdis.9b00419
https://doi.org/10.1021/acsinfecdis.9b00419
Autor:
Jean-Philippe Côté, Zaid Sameer, Michael J. Ellis, Troy Lister, Maya A. Farha, Nicole Cotroneo, Aileen Rubio, Shawn French, Eric D. Brown
Publikováno v:
ACS Infectious Diseases. 6:1405-1412
Therapeutics targeting Gram-negative bacteria have the challenge of overcoming a formidable outer membrane (OM) barrier. Here, we characterize the action of SPR741, a novel polymyxin B (PMB) analogue shown to potentiate several large-scaffold antibio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f332fa696abb0ef8fda8605e0e609028
https://doi.org/10.1021/acsinfecdis.9b00159
https://doi.org/10.1021/acsinfecdis.9b00159
Autor:
Maya A. Farha, Eric D. Brown
Publikováno v:
Nature Microbiology. 4:565-577
Antimicrobial resistance continues to be a public threat on a global scale. The ongoing need to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens has spurred the research community to invest in various drug dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea7c8a28b85494a2fafa88589c9ca4c3
https://doi.org/10.1038/s41564-019-0357-1
https://doi.org/10.1038/s41564-019-0357-1