Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll-like receptors

Autor: Cezmi A. Akdis, Flurina Meiler, Mübeccel Akdis, Maya Zimmermann, Sven Klunker

Publikováno v: Allergy. 63:1455-1463

Background: Allergic diseases are characterized by the activation of the immune system and formation of immunoglobulin (Ig)E antibodies against normally innocuous environmental antigens, whereas IgG4 and IgA represent noninflammatory and blocking ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d68b101fd87e04cddd55b9a116a95c
https://doi.org/10.1111/j.1398-9995.2008.01774.x

Regulatorische T-Zellen in der normalen Immunantwort und in der allergenspezifischen Immuntherapie

Autor: Flurina Meiler, Maya Zimmermann, Mübeccel Akdis, Cezmi A. Akdis

Publikováno v: Allergologie. 28:230-237

Anergy, tolerance and active suppression may not be independent events but rather involve similar mechanisms and cell types in immune regulation. Induction of allergen-specific T r e g cells seems essential for maintaining a non-pathologic immune res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf016f5fd8baabe00a0235f593bc5c76
https://doi.org/10.5414/alp28230

MicroRNA-146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes

Autor: Maya Zimmermann, Nikoletta Nagy, Beate Rückert, Külli Kingo, Mario Plaas, Mei Li, Julia Maslovskaja, Angela Treis, Alar Aab, Cezmi A. Akdis, Uku Haljasorg, H. Hermann, Triin Erm, Lajos Kemény, Maire Pihlap, Jaanika Kärner, Mark Boldin, Ana Rebane, Toomas Runnel

Publikováno v: Journal of Allergy and Clinical Immunology
Europe PubMed Central
ResearcherID
Journal of Allergy and Clinical Immunology, Elsevier, 2014, 134 (4), pp.836-847.e11. ⟨10.1016/j.jaci.2014.05.022⟩

Background Chronic skin inflammation in atopic dermatitis (AD) is associated with elevated expression of proinflammatory genes and activation of innate immune responses in keratinocytes. microRNAs (miRNAs) are short, single-stranded RNA molecules tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d42f79b4da384fe6425ab15bbaca05cf

Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases

Autor: Mübeccel, Akdis, Simone, Burgler, Reto, Crameri, Thomas, Eiwegger, Hiroyuki, Fujita, Enrique, Gomez, Sven, Klunker, Norbert, Meyer, Liam, O'Mahony, Oscar, Palomares, Claudio, Rhyner, Nadia, Ouaked, Nadia, Quaked, Anna, Schaffartzik, Willem, Van De Veen, Sabine, Zeller, Maya, Zimmermann, Cezmi A, Akdis

Publikováno v: The Journal of allergy and clinical immunology

Advancing our understanding of mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections could lead to effective and targeted therapies. Subsets of immune and inflammator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcd2db11bcfdf6611a1f0d9bb33a846
https://www.zora.uzh.ch/id/eprint/60300/

TNF-like weak inducer of apoptosis (TWEAK) and TNF-α cooperate in the induction of keratinocyte apoptosis

Autor: Norbert Meyer, Maya Zimmermann, Flurina Meiler, Cezmi A. Akdis, Burgler Simone, Lajos Kemény, Peter Schmid-Grendelmeier, Katharina Moritz, Stefan Woehrl, Andrea Koreck, Tomasz M. Basinski, Thomas Eiwegger

Publikováno v: The Journal of allergy and clinical immunology. 127(1)

Background Activation of skin keratinocytes followed by their apoptotic death leads to eczema and spongiosis formations in patients with atopic dermatitis (AD). TNF-like weak inducer of apoptosis (TWEAK) binds to its receptor, fibroblast growth facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124017113d451d5b277d078e815ceef7
https://pubmed.ncbi.nlm.nih.gov/21211655