Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Maya, Topf"'
Autor:
Gerard J. Kleywegt, Paul D. Adams, Sarah J. Butcher, Catherine L. Lawson, Alexis Rohou, Peter B. Rosenthal, Sriram Subramaniam, Maya Topf, Sanja Abbott, Philip R. Baldwin, John M. Berrisford, Gérard Bricogne, Preeti Choudhary, Tristan I. Croll, Radostin Danev, Sai J. Ganesan, Timothy Grant, Aleksandras Gutmanas, Richard Henderson, J. Bernard Heymann, Juha T. Huiskonen, Andrei Istrate, Takayuki Kato, Gabriel C. Lander, Shee-Mei Lok, Steven J. Ludtke, Garib N. Murshudov, Ryan Pye, Grigore D. Pintilie, Jane S. Richardson, Carsten Sachse, Osman Salih, Sjors H. W. Scheres, Gunnar F. Schroeder, Carlos Oscar S. Sorzano, Scott M. Stagg, Zhe Wang, Rangana Warshamanage, John D. Westbrook, Martyn D. Winn, Jasmine Y. Young, Stephen K. Burley, Jeffrey C. Hoch, Genji Kurisu, Kyle Morris, Ardan Patwardhan, Sameer Velankar
Publikováno v:
IUCrJ, Vol 11, Iss 2, Pp 140-151 (2024)
In January 2020, a workshop was held at EMBL-EBI (Hinxton, UK) to discuss data requirements for the deposition and validation of cryoEM structures, with a focus on single-particle analysis. The meeting was attended by 47 experts in data processing, m
Externí odkaz:
https://doaj.org/article/0e43f020fe4a4894b6f5aa6a5fd3dc2f
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Cryo-EM experiments produce images of macromolecular assemblies that are combined to produce three-dimensional density maps. Typically, atomic models of the constituent molecules are fitted into these maps, followed by a density-guided refin
Externí odkaz:
https://doaj.org/article/5f1fe009c839496cbeae8fd241c93ad3
Autor:
Guendalina Marini, Brad Poland, Chris Leininger, Natalya Lukoyanova, Dan Spielbauer, Jennifer K. Barry, Dan Altier, Amy Lum, Eric Scolaro, Claudia Pérez Ortega, Nasser Yalpani, Gary Sandahl, Tim Mabry, Jeffrey Klever, Timothy Nowatzki, Jian-Zhou Zhao, Amit Sethi, Adane Kassa, Virginia Crane, Albert L. Lu, Mark E. Nelson, Narayanan Eswar, Maya Topf, Helen R. Saibil
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The broad adoption of transgenic crops has revolutionized agriculture. However, resistance to insecticidal proteins by agricultural pests poses a continuous challenge to maintaining crop productivity and new proteins are urgently needed to r
Externí odkaz:
https://doaj.org/article/d2784a4f824b4587ab65f58ba0743143
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here, the authors present Protein Interface-score (PI-score), a machine learning-based metric that has been trained on protein–protein interfaces’ features from high-resolution crystal structures. They use the PI-score to evaluate the protein–p
Externí odkaz:
https://doaj.org/article/acd3b58ac1e54f71ae0b83863127e269
Autor:
Kimberley M. Reid, Dora Steel, Sanjana Nair, Sanjay Bhate, Lorenzo Biassoni, Sniya Sudhakar, Michelle Heys, Elizabeth Burke, Erik-Jan Kamsteeg, Genomics England Research Consortium, Biju Hameed, Michael Zech, Niccolo E. Mencacci, Katy Barwick, Maya Topf, Manju A. Kurian
Publikováno v:
Cells, Vol 12, Iss 7, p 1046 (2023)
The human dopaminergic system is vital for a broad range of neurological processes, including the control of voluntary movement. Here we report a proband presenting with clinical features of dopamine deficiency: severe infantile parkinsonism-dystonia
Externí odkaz:
https://doaj.org/article/1728f6bc10c74f3983b7b4bf2b3fd894
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Externí odkaz:
https://doaj.org/article/df5b4b4f33f4417691232cfc39be9645
Autor:
Athanasios Ignatiou, Sandrine Brasilès, Mehdi El Sadek Fadel, Jörg Bürger, Thorsten Mielke, Maya Topf, Paulo Tavares, Elena V. Orlova
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Viral assembly is a complex process that in tailed bacteriophages involves scaffolding proteins which coordinate assembly of the phage procapsid and are subsequently released during maturation. Here the authors reveal the conformational changes that
Externí odkaz:
https://doaj.org/article/9550faea551f487fbc11250461307f8f
Autor:
Anaïs Menny, Marina Serna, Courtney M. Boyd, Scott Gardner, Agnel Praveen Joseph, B. Paul Morgan, Maya Topf, Nicholas J. Brooks, Doryen Bubeck
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The complement membrane attack complex (MAC) is a lytic immune pore that kills pathogens. Here the authors use cryoEM to provide a structural and biophysical mechanism for how β-pore forming proteins breach the lipid bilayer, providing pathways to e
Externí odkaz:
https://doaj.org/article/4bd0eaed6b53416380fc69476cf0e63b
Autor:
Dora Batia Dyne Steel, Federica Rachele Danti, Mohamed Abunada, Benjamin Kamien, Sony Malhotra, Maya Topf, Marios Kaliakatsos, Jane Valentine, Andrea Hilary Nemeth, Sandeep Jayawant, Kimberley M. Reid, Kshitij Mankad, Sniya Sudhakar, Hilla Ben-Pazi, Katy Barwick, Manju A. Kurian
Publikováno v:
Neurology. 100:e2214-e2223
Background and ObjectivesBirk-Landau-Perez syndrome is a genetic disorder caused by biallelic pathogenic variants inSLC30A9presenting with a complex movement disorder, developmental regression, oculomotor abnormalities, and renal impairment. It has p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dce8e916ac3e27864a32d62742d16c2
https://doi.org/10.1212/wnl.0000000000207241
https://doi.org/10.1212/wnl.0000000000207241
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
N-methyl-d-aspartate-receptors (NMDARs) are glutamate receptors critical for synaptic transmission, plasticity, and cognition. Here, the authors look at four neurodevelopmental disease-related mutations of NMDAR, gaining insight into binding of Mg2+
Externí odkaz:
https://doaj.org/article/0335c41e3ce04f4db7a70da75d5832f0