Zobrazeno 1 - 10
of 89
pro vyhledávání: '"May-yun Wang"'
Autor:
Toshiharu Onodera, May-Yun Wang, Joseph M. Rutkowski, Stanislaw Deja, Shiuhwei Chen, Michael S. Balzer, Dae-Seok Kim, Xuenan Sun, Yu A. An, Bianca C. Field, Charlotte Lee, Ei-ichi Matsuo, Monika Mizerska, Ina Sanjana, Naoto Fujiwara, Christine M. Kusminski, Ruth Gordillo, Laurent Gautron, Denise K. Marciano, Ming Chang Hu, Shawn C. Burgess, Katalin Susztak, Orson W. Moe, Philipp E. Scherer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Adiponectin is a secretory protein, primarily produced in adipocytes. However, low but detectable expression of adiponectin can be observed in cell types beyond adipocytes, particularly in kidney tubular cells, but its local renal role is un
Externí odkaz:
https://doaj.org/article/6885cd75dd3641e481d840972315e815
Autor:
Toshiharu Onodera, Dae-Seok Kim, Risheng Ye, May-Yun Wang, Shiuhwei Chen, Bianca C. Field, Leon Straub, Xue-Nan Sun, Chao Li, Charlotte Lee, Megan Paredes, Clair Crewe, Shangang Zhao, Christine M. Kusminski, Ruth Gordillo, Philipp E. Scherer
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101821- (2023)
The disease progression of the metabolic syndrome is associated with prolonged hyperlipidemia and insulin resistance, eventually giving rise to impaired insulin secretion, often concomitant with hypoadiponectinemia. As an adipose tissue derived hormo
Externí odkaz:
https://doaj.org/article/2a4c59c398c7494fb3ba2aafae8e0020
Autor:
Na Li, Shangang Zhao, Zhuzhen Zhang, Yi Zhu, Christy M Gliniak, Lavanya Vishvanath, Yu A An, May-yun Wang, Yingfeng Deng, Qingzhang Zhu, Bo Shan, Amber Sherwood, Toshiharu Onodera, Orhan K Oz, Ruth Gordillo, Rana K Gupta, Ming Liu, Tamas L Horvath, Vishwa Deep Dixit, Philipp E Scherer
Publikováno v:
eLife, Vol 10 (2021)
Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects
Externí odkaz:
https://doaj.org/article/cc9c31e77b504b8e89c7e9bde51878cd
Autor:
Shangang Zhao, Na Li, Yi Zhu, Leon Straub, Zhuzhen Zhang, May-Yun Wang, Qingzhang Zhu, Christine M. Kusminski, Joel K. Elmquist, Philipp E. Scherer
Publikováno v:
Molecular Metabolism, Vol 37, Iss , Pp 100995- (2020)
Objective: Hyperleptinemia per se is sufficient to promote leptin resistance in the obese state. Leptin sensitivity can be restored by reducing circulating leptin levels within a physiologically healthy range and is a viable antiobesity and antidiabe
Externí odkaz:
https://doaj.org/article/76d4cc69627b42cf972695e63e028106
Autor:
Ankit X. Sharma, Ezekiel B. Quittner-Strom, Young Lee, Joshua A. Johnson, Sarah A. Martin, Xinxin Yu, Jianping Li, John Lu, Zheqing Cai, Shiuhwei Chen, May-yun Wang, Yiyi Zhang, Mackenzie J. Pearson, Andie C. Dorn, Jeffrey G. McDonald, Ruth Gordillo, Hai Yan, Dung Thai, Zhao V. Wang, Roger H. Unger, William L. Holland
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1760-1773 (2018)
Summary: The antidiabetic potential of glucagon receptor antagonism presents an opportunity for use in an insulin-centric clinical environment. To investigate the metabolic effects of glucagon receptor antagonism in type 2 diabetes, we treated Leprdb
Externí odkaz:
https://doaj.org/article/fc9dc67502904242b84786c20471f0be
Autor:
Xuenan Sun, Yu A. An, Vivian A. Paschoal, Camila O. de Souza, May-yun Wang, Lavanya Vishvanath, Lorena Arango, Ayanna Cobb, Joseph A. Nieto Carrion, Harrison Kidd, Shiuhwei Chen, Wenhong Li, Rana K. Gupta, Da Young Oh
SUMMARYG protein-coupled receptor 84 (GPR84), a medium-chain fatty acid receptor, may be involved in various metabolic conditions but the mechanism remains unclear. We found that GPR84 is highly expressed and functions in brown adipose tissue (BAT).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9d8075bf9b1f1b71c5d2051fd06dc0d
https://doi.org/10.1101/2022.10.26.513863
https://doi.org/10.1101/2022.10.26.513863
Autor:
Na Li, Christine M. Kusminski, Christy M. Gliniak, Ilja L. Kruglikov, Philipp E. Scherer, May-Yun Wang, Zhuzhen Zhang, Zhenzhen Zi, Qingzhang Zhu, Shangang Zhao
Publikováno v:
Experimental Dermatology. 30:102-111
Dermal fibroblasts are an essential population of skin cells. They are not only responsible for synthesis and remodelling of the extracellular matrix of the dermis, but also communicate with other skin cells via autocrine and paracrine interactions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ead767f97d13ea0f72061e4d151df2
https://doi.org/10.1111/exd.14181
https://doi.org/10.1111/exd.14181
Autor:
Ruth Gordillo, Yi Zhu, May-Yun Wang, Christy M. Gliniak, Orhan K. Öz, Tamas L. Horvath, Amber Sherwood, Philipp E. Scherer, Yingfeng Deng, Toshiharu Onodera, Shangang Zhao, Qingzhang Zhu, Bo Shan, Vishwa Deep Dixit, Yu An, Na Li, Rana K. Gupta, Zhuzhen Zhang, Ming Liu, Lavanya Vishvanath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ae9349ab4c625ac4e464942bf4063e6
https://doi.org/10.7554/elife.65108.sa2
https://doi.org/10.7554/elife.65108.sa2
Autor:
May Yun Wang, Greg Poffenberger, Philipp E. Scherer, William L. Holland, Reshing Ye, Ruth E. Gimeno, Yiyi Zhang, Kyle W. Sloop, Derek C. Leonard, S. Kay McCorkle, Alexander M. Efanov, Roger H Unger, Yi Zhu, Alison Von Deylen, Alvin C. Powers, E. Danielle Dean, Shiuhwei Chen, Kamrul H. Chowdhury, Shangang Zhao, Zhuzhen Zhang, Xinxin Yu, Young Chul Lee, Ezekiel B. Quittner-Strom, Na Li, Amnon Schlegel
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Both type 1 and type 2 diabetes are associated with reduced β-cell mass or function, resulting from decreased proliferation and increased apoptosis. Understanding the signals governing β-cell survival and regeneration is critical for d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d54743f23deaa0e45e756854cfbf90f
http://europepmc.org/articles/PMC7936318
http://europepmc.org/articles/PMC7936318