Zobrazeno 1 - 10
of 68
pro vyhledávání: '"May-Ann Lee"'
Autor:
Amanpreet Kaur, Jun Yi Stanley Lim, Sugunavathi Sepramaniam, Siddhi Patnaik, Nathan Harmston, May Ann Lee, Enrico Petretto, David M Virshup, Babita Madan
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp 1-21 (2021)
Abstract Wnt signaling maintains diverse adult stem cell compartments and is implicated in chemotherapy resistance in cancer. PORCN inhibitors that block Wnt secretion have proven effective in Wnt‐addicted preclinical cancer models and are in clini
Externí odkaz:
https://doaj.org/article/e6cc94805b174024ac08e91805f362b0
Autor:
David M. Virshup, Rami N. Hannoush, May Ann Lee, Lijun Ding, Vishal Pendharkar, Zhiyuan Ke, Babita Madan, Kyle David Proffitt
PDF file - 730KB, 1, Uncut gels. 2, Tumor weights, toxicity and target genes of C59 in MMTV-WNT1 mice. 3, Effect on �-catenin by IHC. 4, Effect on tissues by H&E staining.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9b050fee140980c7a9b2d398e506c9
https://doi.org/10.1158/0008-5472.22397252.v1
https://doi.org/10.1158/0008-5472.22397252.v1
Autor:
David M. Virshup, Rami N. Hannoush, May Ann Lee, Lijun Ding, Vishal Pendharkar, Zhiyuan Ke, Babita Madan, Kyle David Proffitt
PDF file - 71KB, C59 does not significantly inhibit the proliferation of any of 46 tested cancer cell lines in vitro at concentrations that completely inhibit PORCN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582126ea42d247e02378f71eaa633045
https://doi.org/10.1158/0008-5472.22397246.v1
https://doi.org/10.1158/0008-5472.22397246.v1
Autor:
David M. Virshup, Rami N. Hannoush, May Ann Lee, Lijun Ding, Vishal Pendharkar, Zhiyuan Ke, Babita Madan, Kyle David Proffitt
PDF file - 156KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54598a8f0442ccb35dc93540f18fecd1
https://doi.org/10.1158/0008-5472.22397249
https://doi.org/10.1158/0008-5472.22397249
Autor:
Susmitha Vuddagiri, Doris Hui Ying Tee, Sandra Sim, Alvin W. Hung, Gang Wang, Thomas H. Keller, Li Hong Tan, Zhiyuan Ke, Anders Poulsen, Nithya Baburajendran, Boping Liu, Vishal Pendharkar, Pearly Shuyi Ng, Jeffrey Hill, Jothi Anantharajan, Joma Joy, May Ann Lee, Zekui Perlyn Kwek, Kanda Sangthongpitag, Sifang Wang, Vithya Manoharan, Klement Foo, Chuhui Huang, Nur Huda Binte Ahmad
Publikováno v:
Bioorganicmedicinal chemistry. 49
AXL is a member of the TAM (TYRO3, AXL, MER) subfamily of receptor tyrosine kinases. It is upregulated in a variety of cancers and its overexpression is associated with poor disease prognosis and acquired drug resistance. Utilizing a fragment-based l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75977880b6d9ca907cbce7ff33cdf1a3
https://pubmed.ncbi.nlm.nih.gov/34600239
https://pubmed.ncbi.nlm.nih.gov/34600239
Autor:
Zheng Zhong, David M. Virshup, Babita Madan, Kris C. Wood, Xin Hui Chew, Sugunavathi Sepramaniam, May Ann Lee
Publikováno v:
Oncogene
Pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) is aggressive and lethal. Although there is an urgent need for effective therapeutics in treating pancreatic cancer, none of the targeted therapies tested in clinical trials to date significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78d99dd5f5e82c3d54e427e67c1392d
https://doi.org/10.1038/s41388-019-0908-1
https://doi.org/10.1038/s41388-019-0908-1
Autor:
Meng Ling Choong, Shan Ho Tan, Tuan Zea Tan, Sravanthy Manesh, Anna Ngo, Jacklyn W Y Yong, Henry He Yang, May Ann Lee
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111146 (2014)
Cell lines recapitulate cancer heterogeneity without the presence of interfering tissue found in primary tumor. Their heterogeneous characteristics are reflected in their multiple genetic abnormalities and variable responsiveness to drug treatments.
Externí odkaz:
https://doaj.org/article/a9e5d335f89842119654ded34afd8996
Autor:
May Ann Lee, Sugunavathi Sepramaniam, Babita Madan, Jun Yi Stanley Lim, Siddhi Patnaik, Enrico Petretto, Amanpreet Kaur, Nathan Harmston, David M. Virshup
Wnt signaling maintains diverse adult stem cell compartments and is implicated in chemotherapy resistance in cancer. PORCN inhibitors that block Wnt secretion have proven effective in Wnt-addicted preclinical cancer models and are in clinical trials.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2396ca192d687ef10c7a6471fbc299a9
https://doi.org/10.1101/2020.06.17.157024
https://doi.org/10.1101/2020.06.17.157024
Autor:
Thomas H. Keller, Zhiyuan Ke, Vithya Manoharan, May Ann Lee, Anders Poulsen, David M. Virshup, Yun Shan Chew, Kanda Sangthongpitag, Vishal Pendharkar, Soo Yei Ho, Eldwin Sum Wai Tan, Choon Bing Low, Jenefer Alam, Li Jun Ding, Weiling Wang, Babita Madan, Shi Hua Ang, Duraiswamy Athisayamani Jeyaraj, Jeffrey Hill, Grace Lin
Publikováno v:
Journal of Medicinal Chemistry. 60:6678-6692
Porcupine is an O-acyltransferase that regulates Wnt secretion. Inhibiting porcupine may block the Wnt pathway which is often dysregulated in various cancers. Consequently porcupine inhibitors are thought to be promising oncology therapeutics. A high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8763bce974412880ac4487a9d29f584
https://doi.org/10.1021/acs.jmedchem.7b00662
https://doi.org/10.1021/acs.jmedchem.7b00662
Autor:
Jeffrey Hill, Joma Joy, Grace Lin, Nurul Dinie, Justina Fulwood, Sin Yin Chew, Xiaoying Koh-Stenta, Sugunavathi Sepramaniam, Xin Hui Chew, Rong Li, Melgious Jin Yan Ang, May Ann Lee, Alex Matter, Weixuan Yu, Zhiyuan Ke, Anna Ngo, Hwa Hwa Chung, Susmitha Vuddagiri, Kanda Sangthongpitag, Klement Foo, Vithya Manoharan, C. S. Brian Chia, Sravanthy Manesh, Esther H. Q. Ong, Nithya Baburajendran, Chuhui Huang, Zekui Perlyn Kwek, John Liang Kuan Wee, Yun Shan Chew, Priya Retna, Thomas H. Keller, Anders Poulsen, Si Si Liew, Choon Bing Low, Vishal Pendharkar
Publikováno v:
ACS Med Chem Lett
[Image: see text] SMYD3 is a histone methyltransferase that regulates gene transcription, and its overexpression is associated with multiple human cancers. A novel class of tetrahydroacridine compounds which inhibit SMYD3 through a covalent mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a957218bb54c41c184fbdaf7cb115a0
https://europepmc.org/articles/PMC6580565/
https://europepmc.org/articles/PMC6580565/