Zobrazeno 1 - 10
of 28
pro vyhledávání: '"May Yin, Lee"'
Autor:
Yi Fei Lee, Cheryl Zi Jin Phua, Ju Yuan, Bin Zhang, May Yin Lee, Srinivasaraghavan Kannan, Yui Hei Jasper Chiu, Casslynn Wei Qian Koh, Choon Kong Yap, Edwin Kok Hao Lim, Jianbin Chen, Yuhua Lim, Jane Jia Hui Lee, Anders Jacobsen Skanderup, Zhenxun Wang, Weiwei Zhai, Nguan Soon Tan, Chandra S. Verma, Yvonne Tay, Daniel Shao Weng Tan, Wai Leong Tam
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-21 (2024)
Abstract Background The identification of cancer driver genes from sequencing data has been crucial in deepening our understanding of tumor biology and expanding targeted therapy options. However, apart from the most commonly altered genes, the mecha
Externí odkaz:
https://doaj.org/article/d7f9b649903749499dd3d17fb11e06b1
Autor:
Viktoriia Iakovleva, Anna Wuestefeld, Agnes Bee Leng Ong, Rong Gao, Neslihan Arife Kaya, May Yin Lee, Weiwei Zhai, Wai Leong Tam, Yock Young Dan, Torsten Wuestefeld
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-17 (2023)
Abstract The liver has a remarkable regenerative capacity. Nevertheless, under chronic liver-damaging conditions, this capacity becomes exhausted, allowing the accumulation of fibrotic tissue and leading to end-stage liver disease. Enhancing the endo
Externí odkaz:
https://doaj.org/article/dc8b2bf168434aafa0a81bb6a80b1f1b
Autor:
Teresa Lai Fong Ho, May Yin Lee, Hui Chin Goh, Germaine Yi Ning Ng, Jane Jia Hui Lee, Srinivasaraghavan Kannan, Yan Ting Lim, Tianyun Zhao, Edwin Kok Hao Lim, Cheryl Zi Jin Phua, Yi Fei Lee, Rebecca Yi Xuan Lim, Perry Jun Hao Ng, Ju Yuan, Dedrick Kok Hong Chan, Bettina Lieske, Choon Seng Chong, Kuok Chung Lee, Jeffrey Lum, Wai Kit Cheong, Khay Guan Yeoh, Ker Kan Tan, Radoslaw M. Sobota, Chandra S. Verma, David P. Lane, Wai Leong Tam, Ashok R. Venkitaraman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Here the authors identify distinct mechanisms by which domain-specific p53 mutations activate cancer cell growth via the epidermal growth factor receptor (EGFR). These mechanisms affect sensitivity to EGFR inhibitors, opening avenues for targeted the
Externí odkaz:
https://doaj.org/article/887b89f317fb487d8e09152d6d299ac4
Autor:
David Tai, Fei Yao, Joycelyn Lee, Su Pin Choo, Joe Yeong, Jeffrey Chun Tatt Lim, Han Chong Toh, Xinru Lim, Jiangfeng Ye, Denise Goh, Tony Kiat-Hon Lim, Mai Chan Lau, Timothy Wai Ho Shuen, Weiwei Zhai, Jia Qi Lim, Lawrence Cheung, Neslihan Arife Kaya, Cheryl Zi Jin Phua, Felicia Yu Ting Wee, Craig Ryan Joseph, Zhen Wei Neo, Kelvin S H Loke, Apoorva Gogna, May Yin Lee, Axel Hilmer, Yun Shen Chan, Wai Leong Tam
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
Background Combination therapy with radioembolization (yttrium-90)-resin microspheres) followed by nivolumab has shown a promising response rate of 30.6% in a Phase II trial (CA209-678) for advanced hepatocellular carcinoma (HCC); however, the respon
Externí odkaz:
https://doaj.org/article/14c8d7451ab74713956c9bc91a18b071
Autor:
May Yin Lee
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Cancer is characterized as a reversion of a differentiated cell to a primitive cell state that recapitulates, in many aspects, features of embryonic cells. This review explores the current knowledge of developmental mechanisms that are essential for
Externí odkaz:
https://doaj.org/article/805931dbff2943c2984c39a7de24914b
Autor:
Nirmala Arul Rayan, Vibhor Kumar, Jonathan Aow, Naghmeh Rastegar, Michelle Gek Liang Lim, Nicholas O’Toole, Edita Aliwarga, Danusa Mar Arcego, Hui Ting Grace Yeo, Jen Yi Wong, May Yin Lee, Florian Schmidt, Hajira Shreen Haja, Wai Leong Tam, Tie-Yuan Zhang, Josie Diorio, Christoph Anacker, Rene Hen, Carine Parent, Michael J Meaney, Shyam Prabhakar
Publikováno v:
Molecular Psychiatry. 27:4510-4525
Depression and anxiety are major global health burdens. Although SSRIs targeting the serotonergic system are prescribed over 200 million times annually, they have variable therapeutic efficacy and side effects, and mechanisms of action remain incompl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc06ddc305fbbd950921fb8126b2e3c
https://doi.org/10.1038/s41380-022-01725-1
https://doi.org/10.1038/s41380-022-01725-1
Autor:
Junichi Matsuo, Naing Naing Mon, Daisuke Douchi, Akihiro Yamamura, Madhura Kulkarni, Dede Liana Heng, Sabirah Chen, Napat Nuttonmanit, Ying Li, Henry Yang, May Yin Lee, Wai Leong Tam, Motomi Osato, Linda Shyue Huey Chuang, Yoshiaki Ito
Publikováno v:
Stem Cells. 40:112-122
Mammary gland homeostasis is maintained by adult tissue stem-progenitor cells residing within the luminal and basal epithelia. Dysregulation of mammary stem cells is a key mechanism for cancer development. However, stem cell characterization is chall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07193a5ca3598320fdd7b3454a600f42
https://doi.org/10.1093/stmcls/sxab009
https://doi.org/10.1093/stmcls/sxab009
Autor:
Yu-Hsiu Wang, Teresa L. F. Ho, Anushya Hariharan, Hui Chin Goh, Yao Liang Wong, Nicole S. Verkaik, May Yin Lee, Wai Leong Tam, Dik C. van Gent, Ashok R. Venkitaraman, Michael P. Sheetz, David P. Lane
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 119(10):e2113233119. National Academy of Sciences
p53 is primarily known as a downstream transcriptional effector in the DNA damage-response cascade. We report that endogenous p53 rapidly accumulates at DNA damage sites within 2 s of UVA microirradiation. The kinetics of p53 recruitment mimics those
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a914d4ebebdd22e3a80bf79e6a4162
https://pure.eur.nl/en/publications/8dd04be0-2828-4841-83dd-f0509b65b06e
https://pure.eur.nl/en/publications/8dd04be0-2828-4841-83dd-f0509b65b06e
Autor:
Upadhyayula S. Srinivas, Norbert S. C. Tay, Patrick Jaynes, Akshaya Anbuselvan, Gokula K. Ramachandran, Joanna D. Wardyn, Michal M. Hoppe, Phuong Mai Hoang, Yanfen Peng, Sherlly Lim, May Yin Lee, Praveen C. Peethala, Omer An, Akshay Shendre, Bryce W. Q. Tan, Sherlyn Jemimah, Manikandan Lakshmanan, Longyu Hu, Rekha Jakhar, Karishma Sachaphibulkij, Lina H. K. Lim, Shazib Pervaiz, Karen Crasta, Henry Yang, Patrick Tan, Chao Liang, Lena Ho, Vartika Khanchandani, Dennis Kappei, Wei Peng Yong, David S. P. Tan, Matteo Bordi, Silvia Campello, Wai Leong Tam, Christian Frezza, Anand D. Jeyasekharan
Publikováno v:
Oncogene. 41(13)
Inhibitors of the mitotic kinase PLK1 yield objective responses in a subset of refractory cancers. However, PLK1 overexpression in cancer does not correlate with drug sensitivity, and the clinical development of PLK1 inhibitors has been hampered by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddca1ec5cc8283f632a7ab341ef4512d
https://pubmed.ncbi.nlm.nih.gov/35523948
https://pubmed.ncbi.nlm.nih.gov/35523948
Autor:
May Yin Lee, S. Shatishwaran, Roger Foo, Magendran Muniandy, Benita Tan, Joanna Zhen Zhen Yeo, Soo-Chin Lee, Chow Yin Wong, Elina Pathak, Preetha Madhukumar, Li Ping Toh, William Haowei Xie, Wai Leong Tam, Esther Kai Lay Peh, Ju Yuan, Yirong Sim, Veronique Kiak Mien Tan, Lih-Wen Deng, Wilson Wei Sheng Tan, Yin Ying Ho, Elaine Hsuen Lim, Rebecca Dent, Markus R. Wenk, Puay Hoon Tan, Ying Swan Ho, Jack Chan, Siming Ma, Federico Torta, Ser Yue Loo, Yoon Sim Yap, Tira Jing Ying Tan, Wei Sean Yong, Kong Wee Ong
Publikováno v:
Science Advances
Description
Fatty acid oxidation is a metabolic gateway that regulates cellular plasticity and supports metastasis in breast cancer.
Cell state transitions control the functional behavior of cancer cells. Epithelial-to-mesenchymal transitio
Fatty acid oxidation is a metabolic gateway that regulates cellular plasticity and supports metastasis in breast cancer.
Cell state transitions control the functional behavior of cancer cells. Epithelial-to-mesenchymal transitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e6a08d9c6618541c5462a65d49345a
https://hdl.handle.net/10356/154360
https://hdl.handle.net/10356/154360
