Zobrazeno 1 - 10
of 16
pro vyhledávání: '"May W Chen"'
Autor:
Adriana Amrein Almira, May W. Chen, Nagat El Demerdash, Cameron Javdan, Dongseok Park, Jennifer K. Lee, Lee J. Martin
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
IntroductionLoss of proteasome function, proteinopathy, and proteotoxicity may cause neurodegeneration across the human lifespan in several forms of brain injury and disease. Drugs that activate brain proteasomes in vivo could thus have a broad thera
Externí odkaz:
https://doaj.org/article/2403dcf93a9842fab6f349422d995ede
Autor:
Christopher T. Primiani, Jennifer K. Lee, Caitlin E. O’Brien, May W. Chen, Jamie Perin, Ewa Kulikowicz, Polan Santos, Shawn Adams, Bailey Lester, Natalia Rivera-Diaz, Valerie Olberding, Mark V. Niedzwiecki, Eva K. Ritzl, Christa W. Habela, Xiuyun Liu, Zeng-Jin Yang, Raymond C. Koehler, Lee J. Martin
Publikováno v:
Cells, Vol 12, Iss 20, p 2454 (2023)
The effects of hypothermia on neonatal encephalopathy may vary topographically and cytopathologically in the neocortex with manifestations potentially influenced by seizures that alter the severity, distribution, and type of neuropathology. We develo
Externí odkaz:
https://doaj.org/article/ae0556a118e641cd9a3b614c725aad53
Autor:
Xiuyun Liu, Aylin Tekes, Jamie Perin, May W. Chen, Bruno P. Soares, An N. Massaro, Rathinaswamy B. Govindan, Charlamaine Parkinson, Raul Chavez-Valdez, Frances J. Northington, Ken M. Brady, Jennifer K. Lee
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Dysfunctional cerebrovascular autoregulation may contribute to neurologic injury in neonatal hypoxic-ischemic encephalopathy (HIE). Identifying the optimal mean arterial blood pressure (MAPopt) that best supports autoregulation could help identify he
Externí odkaz:
https://doaj.org/article/e46c6c4ccfe441e8b143e2895d312da2
Autor:
Nagat El Demerdash, May W. Chen, Caitlin E. O’Brien, Shawn Adams, Ewa Kulikowicz, Lee J. Martin, Jennifer K. Lee
Publikováno v:
Cells, Vol 10, Iss 8, p 2120 (2021)
Cerebral hypoxia-ischemia (HI) compromises the proteasome in a clinically relevant neonatal piglet model. Protecting and activating proteasomes could be an adjunct therapy to hypothermia. We investigated whether chymotrypsin-like proteasome activity
Externí odkaz:
https://doaj.org/article/c04154d1dd004e9086a813a609f2143b
Autor:
Polan T. Santos, Caitlin E. O'Brien, May W. Chen, C. Danielle Hopkins, Shawn Adams, Ewa Kulikowicz, Rashmi Singh, Raymond C. Koehler, Lee J. Martin, Jennifer K. Lee
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 20 (2018)
Background Neurological deficits in hypoxic‐ischemic encephalopathy, even with therapeutic hypothermia, are partially attributed to white matter injury. We theorized that proteasome insufficiency contributes to white matter injury. Methods and Resu
Externí odkaz:
https://doaj.org/article/dee25330af5e4d3098c46f1298bf20ca
Autor:
May W. Chen, Jennifer K. Lee, Gilbert Vezina, Aylin Tekes, Jamie Perin, Ruoying Li, Alexandra O’Kane, Meaghan McGowan, Taeun Chang, Charlamaine Parkinson, Colleen Krein, Tareq Al-Shargabi, Frances J. Northington, Ken M. Brady, An N. Massaro, Rathinaswamy B. Govindan
Publikováno v:
Dev Neurosci
Identifying the hemodynamic range that best supports cerebral perfusion using near infrared spectroscopy (NIRS) autoregulation monitoring is a potential physiologic marker for neonatal hypoxic-ischemic encephalopathy (HIE) during therapeutic hypother
Autor:
Ruoying Li, Jennifer K. Lee, Rathinaswamy B. Govindan, Ernest M. Graham, Allen D. Everett, Jamie Perin, Gilbert Vezina, Aylin Tekes, May W. Chen, Frances Northington, Charlamaine Parkinson, Alexandra O'Kane, Meaghan McGowan, Colleen Krein, Tareq Al-Shargabi, Taeun Chang, An N. Massaro
Publikováno v:
J Pediatr
OBJECTIVE: The objective of the study was to evaluate the relationship between a panel of candidate plasma biomarkers and (1) death or severe brain injury on magnetic resonance imaging (MRI) and (2) dysfunctional cerebral pressure autoregulation as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f746f67296f1d441dad78bf3b2f8c786
https://europepmc.org/articles/PMC9828943/
https://europepmc.org/articles/PMC9828943/
Autor:
Caitlin E O'Brien, Raymond C. Koehler, Shawn Adams, Polan T. Santos, Ewa Kulikowicz, Henry Hardart, Jennifer K. Lee, Lee J. Martin, May W Chen
Publikováno v:
J Neuropathol Exp Neurol
Neonatal hypoxia-ischemia (HI) causes white matter injury that is not fully prevented by therapeutic hypothermia. Adjuvant treatments are needed. We compared myelination in different piglet white matter regions. We then tested whether oleuropein (OLE
Autor:
Ewa Kulikowicz, May W Chen, Caitlin E O'Brien, Shawn Adams, Nagat El Demerdash, Jennifer K. Lee, Lee J. Martin
Publikováno v:
Cells
Cells, Vol 10, Iss 2120, p 2120 (2021)
Volume 10
Issue 8
Cells, Vol 10, Iss 2120, p 2120 (2021)
Volume 10
Issue 8
Cerebral hypoxia-ischemia (HI) compromises the proteasome in a clinically relevant neonatal piglet model. Protecting and activating proteasomes could be an adjunct therapy to hypothermia. We investigated whether chymotrypsin-like proteasome activity
Autor:
Ravit Arav-Boger, May W. Chen, Khalil G. Ghanem, Barbara Detrick, Kathleen R. Page, Frank R. Witter, W. Christopher Golden, Paul K. Sue, Ibukunoluwa C. Akinboyo, Pamela Donohue
Publikováno v:
Journal of Perinatology. 39:956-963
Objectives To examine the effect of maternal reverse-sequence (RS) syphilis screening on management of infants at risk for congenital syphilis (CS) using a standardized approach. Study design A retrospective study from 2011 to 2014 at an academic med