Elevated c-di-GMP Levels and Expression of the Type III Secretion System Promote Corneal Infection by Pseudomonas aeruginosa

Autor: Joey Kuok Hoong Yam, Thet Tun Aung, Song Lin Chua, Yingying Cheng, Gurjeet Singh Kohli, Jianuan Zhou, Florentin Constancias, Yang Liu, Zhao Cai, May Margarette Santillan Salido, Daniela I. Drautz-Moses, Scott A. Rice, Stephan Christoph Schuster, Zhao Zhi Boo, Bin Wu, Staffan Kjelleberg, Tim Tolker-Nielsen, Rajamani Lakshminarayanan, Roger W. Beuerman, Liang Yang, Michael Givskov

Publikováno v: Infection and immunity, 90 (8)
Yam, J K H, Aung, T T, Chua, S L, Cheng, Y, Kohli, G S, Zhou, J, Constancias, F, Liu, Y, Cai, Z, Salido, M M S, Drautz-Moses, D I, Rice, S A, Schuster, S C, Boo, Z Z, Wu, B, Kjelleberg, S, Tolker-Nielsen, T, Lakshminarayanan, R, Beuerman, R W, Yang, L & Givskov, M 2022, ' Elevated c-di-GMP Levels and Expression of the Type III Secretion System Promote Corneal Infection by Pseudomonas aeruginosa ', Infection and Immunity, vol. 90, no. 8 . https://doi.org/10.1128/iai.00061-22

Pseudomonas aeruginosa is generally believed to establish biofilm-associated infections under the regulation of the secondary messenger c-di-GMP. To evaluate P. aeruginosa biofilm physiology during ocular infections, comparative transcriptomic analys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faabfddccbc986ff3c6cef4e563402a5
https://hdl.handle.net/10453/164130

Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents

Autor: Choon-Hong Tan, Song Lin Chua, Liang Yang, Roger W. Beuerman, Yang Liu, Michael Givskov, Mingjun Yuan, Thomas E. Nielsen, Daniela I. Drautz-Moses, Stephan C. Schuster, May Margarette Santillan Salido, Joey Kuok Hoong Yam, Thet Tun Aung

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 3059-3069 (2018)
Yuan, M, Chua, S L, Liu, Y, Drautz-Moses, D I, Hoong Yam, J K, Aung, T T, Beuerman, R W, Santillan Salido, M M, Schuster, S C, Tan, C H, Givskov, M, Yang, L & Nielsen, T E 2018, ' Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents ', Beilstein Journal of Organic Chemistry, vol. 14, pp. 3059-3069 . https://doi.org/10.3762/bjoc.14.284

Antibiotic resistance threatens effective treatment of microbial infections globally. This situation has spurred the hunt for new antimicrobial compounds in both academia and the pharmaceutical industry. Here, we report how the widely used antitumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5076c2df0a969449bc4edb8bb2ae8b
https://doaj.org/article/753a8d0395f842239fb8a40c6d273c36

Cyclic-di-GMP is required for corneal infection byPseudomonas aeruginosaand modulates host immunity

Autor: Roger W. Beuerman, Michael Givskov, Scott A. Rice, Liang Yang, Yingying Cheng, Yang Liu, Song Lin Chua, Thet Tun Aung, Joey Kuok Hoong Yam, Staffan Kjelleberg, Jianuan Zhou, Florentin Constancias, Stephan C. Schuster, Tim Tolker-Nielsen, Daniela I. Drautz-Moses, Zhao Cai, Bin Wu, May Margarette Santillan Salido, Gurjeet S. Kohli

Biofilms are extremely tolerant toward antimicrobial treatment and host immune clearance due to their distinct physiology and protection by extracellular polymeric substances. Bis-(3´-5´)-cyclic dimeric guanosine monophosphate (c-di-GMP) is an esse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f2d1a617801f92da60a1ee03a51a28
https://doi.org/10.1101/098749

Selective labelling and eradication of antibiotic-tolerant bacterial populations in Pseudomonas aeruginosa biofilms

Autor: Song Lin Chua, Tim Tolker-Nielsen, Sunil S. Adav, Yang Liu, Michael Givskov, Siu Kwan Sze, Joey Kuok Hoong Yam, Liang Yang, May Margarette Santillan Salido, Piliang Hao

Publikováno v: Chua, S L, Yam, J K H, Hao, P, Adav, S S, Salido, M M, Liu, Y, Givskov, M, Sze, S K, Tolker-Nielsen, T & Yang, L 2016, ' Selective labelling and eradication of antibiotic-tolerant bacterial populations in Pseudomonas aeruginosa biofilms ', Nature Communications, vol. 7, 10750 . https://doi.org/10.1038/ncomms10750
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)

Drug resistance and tolerance greatly diminish the therapeutic potential of antibiotics against pathogens. Antibiotic tolerance by bacterial biofilms often leads to persistent infections, but its mechanisms are unclear. Here we use a proteomics appro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a55a369e3605318efc36b5dd81bcb0f
https://curis.ku.dk/portal/da/publications/selective-labelling-and-eradication-of-antibiotictolerant-bacterial-populations-in-pseudomonas-aeruginosa-biofilms(2c97ae11-97cf-484b-bcd9-b0c52529d2b9).html