Multimeric assembly of host-pathogen adhesion complexes involved in apicomplexan invasion.

Autor: May M Paing, Niraj H Tolia

Publikováno v: PLoS Pathogens, Vol 10, Iss 6, p e1004120 (2014)

Externí odkaz: https://doaj.org/article/a8680a70e7aa41649d1555ff4a84cb34

DNAJB6 isoform specific knockdown: Therapeutic potential for limb girdle muscular dystrophy D1

Autor: Andrew R. Findlay, May M. Paing, Jil A. Daw, Meade Haller, Rocio Bengoechea, Sara K. Pittman, Shan Li, Feng Wang, Timothy M. Miller, Heather L. True, Tsui-Fen Chou, Conrad C. Weihl

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 937-948 (2023)

Dominant missense mutations in DNAJB6, a co-chaperone of HSP70, cause limb girdle muscular dystrophy (LGMD) D1. No treatments are currently available. Two isoforms exist, DNAJB6a and DNAJB6b, each with distinct localizations in muscle. Mutations resi

Externí odkaz: https://doaj.org/article/98875bfcbb0241d7a450adbfdbc2b0b5

Moderately Neutralizing Epitopes in Nonfunctional Regions Dominate the Antibody Response to Plasmodium falciparum EBA-140

Autor: Niraj H. Tolia, Michael L. Gross, Nichole D. Salinas, May M. Paing, Jagat Adhikari

Plasmodium falciparum erythrocyte-binding antigen 140 (EBA-140) plays a role in tight junction formation during parasite invasion of red blood cells and is a potential vaccine candidate for malaria. Individuals in areas where malaria is endemic posse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77db4197938b96fbe938922fb8519fe
https://europepmc.org/articles/PMC6434137/

Shed EBA-175 mediates red blood cell clustering that enhances malaria parasite growth and enables immune evasion

Autor: Anna Oksman, Yvonne Adams, Anja T. R. Jensen, Daniel E. Goldberg, May M. Paing, Niraj H. Tolia, Nichole D. Salinas

Publikováno v: eLife
eLife, Vol 7 (2018)
Paing, M M, Salinas, N D, Adams, Y, Oksman, A, Jensen, A TR, Goldberg, D E & Tolia, N H 2018, ' Shed EBA-175 mediates red blood cell clustering that enhances malaria parasite growth and enables immune evasion ', eLife, vol. 7, e43224 . https://doi.org/10.7554/eLife.43224

Erythrocyte Binding Antigen of 175 kDa (EBA-175) has a well-defined role in binding to glycophorin A (GpA) during Plasmodium falciparum invasion of erythrocytes. However, EBA-175 is shed post invasion and a role for this shed protein has not been def

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b206b939629417ec9201f7d8ee09674
http://europepmc.org/articles/PMC6305201

G Protein–Coupled Receptor Sorting to Endosomes and Lysosomes

Autor: Adriano Marchese, May M. Paing, Brenda Temple, JoAnn Trejo

Publikováno v: Annual Review of Pharmacology and Toxicology. 48:601-629

The heptahelical G protein–coupled receptors (GPCRs) belong to the largest family of cell surface signaling receptors encoded in the human genome. GPCRs signal to diverse extracellular stimuli and control a vast number of physiological responses, m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c550db9de5948e1c1db8b0d8b7a5e61a
https://doi.org/10.1146/annurev.pharmtox.48.113006.094646